Entrezgene ::= {
track-info {
geneid 1 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 3 ,
day 19 ,
hour 10 ,
minute 30 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "19" } } } ,
gene {
locus "A1BG" ,
desc "alpha-1-B glycoprotein" ,
maploc "19q13.4" ,
db {
{
db "MIM" ,
tag
id 138670 } } ,
syn {
"A1B" ,
"ABG" ,
"GAB" ,
"HYST2477" ,
"DKFZp686F0970" } ,
locus-tag "HGNC:5" } ,
prot {
name {
"alpha 1B-glycoprotein" ,
"alpha-1B-glycoprotein" } } ,
summary "The protein encoded by this gene is a plasma glycoprotein of
unknown function. The protein shows sequence similarity to the variable
regions of some immunoglobulin supergene family member proteins." ,
location {
{
display-str "19q13.4" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 1 ,
src-str2 "1" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000019" ,
version 8 ,
seqs {
int {
from 63548355 ,
to 63556668 ,
strand minus ,
id
gi 42406306 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_130786" ,
version 2 ,
genomic-coords {
mix {
int {
from 63548355 ,
to 63550206 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63550530 ,
to 63550817 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63553547 ,
to 63553828 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63554568 ,
to 63554864 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63555460 ,
to 63555732 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63556105 ,
to 63556374 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63556469 ,
to 63556504 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63556581 ,
to 63556668 ,
strand minus ,
id
gi 42406306 } } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_570602" ,
version 2 ,
genomic-coords {
packed-int {
{
from 63550199 ,
to 63550206 ,
strand minus ,
id
gi 42406306 } ,
{
from 63550530 ,
to 63550817 ,
strand minus ,
id
gi 42406306 } ,
{
from 63553547 ,
to 63553828 ,
strand minus ,
id
gi 42406306 } ,
{
from 63554568 ,
to 63554864 ,
strand minus ,
id
gi 42406306 } ,
{
from 63555460 ,
to 63555732 ,
strand minus ,
id
gi 42406306 } ,
{
from 63556105 ,
to 63556374 ,
strand minus ,
id
gi 42406306 } ,
{
from 63556469 ,
to 63556504 ,
strand minus ,
id
gi 42406306 } ,
{
from 63556581 ,
to 63556614 ,
strand minus ,
id
gi 42406306 } } } ,
seqs {
whole
gi 21071030 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_011109" ,
version 15 ,
seqs {
int {
from 31124733 ,
to 31133046 ,
strand minus ,
id
gi 29800594 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_130786" ,
version 2 ,
genomic-coords {
mix {
int {
from 31124733 ,
to 31126584 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31126908 ,
to 31127195 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31129925 ,
to 31130206 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31130946 ,
to 31131242 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31131838 ,
to 31132110 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31132483 ,
to 31132752 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31132847 ,
to 31132882 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31132959 ,
to 31133046 ,
strand minus ,
id
gi 29800594 } } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_570602" ,
version 2 ,
genomic-coords {
packed-int {
{
from 31126577 ,
to 31126584 ,
strand minus ,
id
gi 29800594 } ,
{
from 31126908 ,
to 31127195 ,
strand minus ,
id
gi 29800594 } ,
{
from 31129925 ,
to 31130206 ,
strand minus ,
id
gi 29800594 } ,
{
from 31130946 ,
to 31131242 ,
strand minus ,
id
gi 29800594 } ,
{
from 31131838 ,
to 31132110 ,
strand minus ,
id
gi 29800594 } ,
{
from 31132483 ,
to 31132752 ,
strand minus ,
id
gi 29800594 } ,
{
from 31132847 ,
to 31132882 ,
strand minus ,
id
gi 29800594 } ,
{
from 31132959 ,
to 31132992 ,
strand minus ,
id
gi 29800594 } } } ,
seqs {
whole
gi 21071030 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_086907" ,
version 1 ,
seqs {
int {
from 8163589 ,
to 8172398 ,
strand minus ,
id
gi 51475048 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_130786" ,
version 2 ,
genomic-coords {
mix {
int {
from 8163589 ,
to 8165440 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8165763 ,
to 8166050 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8169274 ,
to 8169555 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8170297 ,
to 8170593 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8171190 ,
to 8171462 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8171835 ,
to 8172104 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8172199 ,
to 8172234 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8172311 ,
to 8172398 ,
strand minus ,
id
gi 51475048 } } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_570602" ,
version 2 ,
genomic-coords {
packed-int {
{
from 8165433 ,
to 8165440 ,
strand minus ,
id
gi 51475048 } ,
{
from 8165763 ,
to 8166050 ,
strand minus ,
id
gi 51475048 } ,
{
from 8169274 ,
to 8169555 ,
strand minus ,
id
gi 51475048 } ,
{
from 8170297 ,
to 8170593 ,
strand minus ,
id
gi 51475048 } ,
{
from 8171190 ,
to 8171462 ,
strand minus ,
id
gi 51475048 } ,
{
from 8171835 ,
to 8172104 ,
strand minus ,
id
gi 51475048 } ,
{
from 8172199 ,
to 8172234 ,
strand minus ,
id
gi 51475048 } ,
{
from 8172311 ,
to 8172344 ,
strand minus ,
id
gi 51475048 } } } ,
seqs {
whole
gi 21071030 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "A1BG" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "alpha-1-B glycoprotein" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "GOA" ,
url "http://www.ebi.ac.uk/GOA/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 3458201 } ,
source {
{
src {
db "GO" ,
tag
id 5554 } ,
anchor "molecular_function unknown" ,
post-text "evidence: ND" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 4 } ,
anchor "biological_process unknown" ,
post-text "evidence: ND" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 3458201 } ,
source {
{
src {
db "GO" ,
tag
id 5576 } ,
anchor "extracellular region" ,
post-text "evidence: IDA" } } } } } } } } ,
homology {
{
type comment ,
heading "Mouse, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 11167 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=19&
MAPS=genes-r-org/rat-chr/human%3A19,genes-r-org/mouse-chr/human%3A19,genes-r-o
rg/human-chr19&query=e%3A1[id]+AND+gene[obj_type]&QSTR=a1bg&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "HGNC" ,
tag
id 5 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15461460 ,
pmid 15221005 ,
pmid 14702039 ,
pmid 12477932 ,
pmid 8889549 ,
pmid 3458201 ,
pmid 2591067 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 89991 } ,
anchor "SHGC-67307" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "RH80032" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH86145" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 152074 } ,
anchor "D11S2921" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "GDB:461809" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 155756 } ,
anchor "D10S16" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "D10S23" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "GDB:193809" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_130786" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 21071029 } ,
anchor "NM_130786" } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_570602" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 21071030 } ,
anchor "NP_570602" ,
post-text "alpha 1B-glycoprotein" } } ,
seqs {
whole
gi 21071030 } ,
comment {
{
type other ,
heading "Consensus CDS (CCDS)" ,
version 0 ,
source {
{
src {
db "CCDS" ,
tag
str "CCDS12976.1" } ,
anchor "CCDS12976.1" } } } ,
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 21071030 } ,
pre-text "(1)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 365 } ,
anchor "smart00408: IGc2; Immunoglobulin C-2 Type" } } ,
comment {
{
type other ,
text "Location: 223 - 282 Blast Score: 103" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "AF414429,AK055885,AK056201" } ,
anchor "AF414429,AK055885,AK056201" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "AC010642" ,
version 5 ,
source {
{
src {
db "Nucleotide" ,
tag
id 9929687 } ,
anchor "AC010642" } } ,
seqs {
int {
from 41119 ,
to 43581 ,
strand plus ,
id
gi 9929687 } } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AB073611" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 51555784 } ,
anchor "AB073611" } } ,
seqs {
whole
gi 51555784 } ,
products {
{
type peptide ,
accession "BAD38648" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 51555785 } ,
anchor "BAD38648" } } ,
seqs {
whole
gi 51555785 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AF414429" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 15778555 } ,
anchor "AF414429" } } ,
seqs {
whole
gi 15778555 } ,
products {
{
type peptide ,
accession "AAL07469" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 15778556 } ,
anchor "AAL07469" } } ,
seqs {
whole
gi 15778556 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK055885" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 16550723 } ,
anchor "AK055885" } } ,
seqs {
whole
gi 16550723 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK056201" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 16551539 } ,
anchor "AK056201" } } ,
seqs {
whole
gi 16551539 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC035719" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 23273475 } ,
anchor "BC035719" } } ,
seqs {
whole
gi 23273475 } ,
products {
{
type peptide ,
accession "AAH35719" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 23273476 } ,
anchor "AAH35719" } } ,
seqs {
whole
gi 23273476 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BX537419" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 31873339 } ,
anchor "BX537419" } } ,
seqs {
whole
gi 31873339 } ,
products {
{
type peptide ,
accession "CAD97661" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 31873340 } ,
anchor "CAD97661" } } ,
seqs {
whole
gi 31873340 } } } } ,
{
type other ,
text "None" ,
version 0 ,
products {
{
type peptide ,
accession "P04217" ,
version 0 ,
source {
{
src {
db "Protein" ,
tag
id 46577680 } ,
anchor "P04217" } } ,
seqs {
whole
gi 46577680 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "1" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
g=NT_011109.15&gene=A1BG&lid=1&from=31124734&to=31133047" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "1" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
06&contig=NT_011109.15&gene=A1BG&lid=1" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Hs.529161" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Hs.529161" } ,
anchor "Hs.529161" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=52
9161" } } } ,
{
type comment ,
text "MIM" ,
version 0 ,
source {
{
src {
db "MIM" ,
tag
str "138670" } ,
anchor "138670" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "1" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
1[loc]&TAXID=9606" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "AceView" ,
tag
id 1 } ,
anchor "AceView" ,
url "http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
ocusid&org=9606&l=1" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GDB" ,
tag
str "GDB:119638" } } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Homo_sapiens/contigview?geneid=AK055
885" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
AK055885" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC035719" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC035719" } } } } } ,
{
type generif ,
text "A1BG-cysteine-rich secretory protein 3 complex displays a similar
function in protecting the circulation from a potentially harmful effect of
free CRISP-3" ,
version 0 ,
refs {
pmid 15461460 } ,
create-date
str "Nov 6 2004 10:01AM" ,
update-date
str "Nov 6 2004 3:27PM" } } ,
unique-keys {
{
db "LocusID" ,
tag
id 1 } ,
{
db "MIM" ,
tag
id 138670 } } ,
xtra-index-terms {
"LOC1" } }
Entrezgene ::= {
track-info {
geneid 2 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 3 ,
hour 13 ,
minute 27 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "12" } } } ,
gene {
locus "A2M" ,
desc "alpha-2-macroglobulin" ,
maploc "12p13.3-p12.3" ,
db {
{
db "MIM" ,
tag
id 103950 } } ,
syn {
"FWP007" ,
"S863-7" ,
"DKFZp779B086" } ,
locus-tag "HGNC:7" } ,
prot {
name {
"alpha-2-macroglobulin" } } ,
summary "Alpha-2-macroglobulin is a protease inhibitor and cytokine
transporter. It inhibits many proteases, including trypsin, thrombin and
collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability
to mediate the clearance and degradation of A-beta, the major component of
beta-amyloid deposits." ,
location {
{
display-str "12p13.3-p12.3" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 2 ,
src-str2 "2" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000012" ,
version 9 ,
seqs {
int {
from 9111576 ,
to 9159755 ,
strand minus ,
id
gi 51511728 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_000014" ,
version 3 ,
genomic-coords {
mix {
int {
from 9111576 ,
to 9111701 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9112045 ,
to 9112086 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9112602 ,
to 9112704 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9113607 ,
to 9113675 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9114350 ,
to 9114440 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9116221 ,
to 9116348 ,
strand minus ,
id
gi 51511728 } ,
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gi 6226959 } ,
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properties {
{
type comment ,
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source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
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type property ,
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text "A2M" ,
version 0 } ,
{
type property ,
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version 0 } } } ,
{
type comment ,
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source {
{
pre-text "Provided by" ,
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comment {
{
type comment ,
label "Function" ,
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comment {
{
type comment ,
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source {
{
src {
db "GO" ,
tag
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anchor "enzyme binding" ,
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{
type comment ,
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pmid 9714181 } ,
source {
{
src {
db "GO" ,
tag
id 19966 } ,
anchor "interleukin-1 binding" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
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pmid 10880251 } ,
source {
{
src {
db "GO" ,
tag
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post-text "evidence: IPI" } } } ,
{
type comment ,
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source {
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src {
db "GO" ,
tag
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anchor "protein carrier activity" ,
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src {
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src {
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src {
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src {
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src {
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anchor "MGC" ,
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{
type comment ,
heading "Pathways" ,
version 0 ,
comment {
{
type comment ,
text "KEGG pathway: Alzheimer's disease" ,
version 0 ,
source {
{
src {
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tag
str "05010" } ,
anchor "05010" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa05010+2" } } } ,
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text "KEGG pathway: Coagulation cascade" ,
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source {
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src {
db "04610" ,
tag
str "04610" } ,
anchor "04610" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
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text "KEGG pathway: Complement and coagulation cascades" ,
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source {
{
src {
db "04610" ,
tag
str "04610" } ,
anchor "04610" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
{
type comment ,
text "Reactome: Hemostasis" ,
version 0 ,
source {
{
anchor "49292" ,
url "http://www.reactome.org/cgi-bin/link?SOURCE=UniProt&ID=P010
23" } } } } } ,
{
type generif ,
text "an important involvement of alpha2M in regulation of increased
proteolytic activity occurring in multiple sclerosis disease" ,
version 0 ,
refs {
pmid 15511627 } ,
create-date
str "Dec 18 2004 10:01AM" ,
update-date
str "Dec 18 2004 1:19PM" } ,
{
type generif ,
text "alpha2-macroglobulin inhibits human pepsin and gastricsin" ,
version 0 ,
refs {
pmid 14506912 } ,
create-date
str "Oct 7 2003 12:00AM" ,
update-date
str "Jul 7 2004 1:36PM" } ,
{
type generif ,
text "There is a significant genetic association of the 5 bp deletion
and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin
precursor with AD" ,
version 0 ,
refs {
pmid 12966032 } ,
create-date
str "Jun 27 2004 5:41PM" ,
update-date
str "Jun 27 2004 6:18PM" } ,
{
type generif ,
text "Alpha2-macroglobulin is a substrate and an endogenous inhibitor
for ADAMTS-4 and ADAMTS-5" ,
version 0 ,
refs {
pmid 14715656 } ,
create-date
str "Jun 14 2004 4:41PM" ,
update-date
str "Jun 14 2004 5:44PM" } ,
{
type generif ,
text "A2M-D allele played a weak Alzheimer disease protective role, and
APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk
for mainland Han Chinese." ,
version 0 ,
refs {
pmid 14675603 } ,
create-date
str "Feb 17 2004 12:00AM" ,
update-date
str "Apr 13 2004 1:35PM" } ,
{
type generif ,
text "Plasma from patients homozygous for the intronic deletion (DD)
showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory
activity. Plasma alpha(2)M from two DD patients showed markedly increased
TGF-beta1 binding." ,
version 0 ,
refs {
pmid 14678766 } ,
create-date
str "Jan 20 2004 12:00AM" ,
update-date
str "Mar 7 2004 7:01AM" } ,
{
type generif ,
text "The presence of MPO-G/G and A2M-Val/Val genotypes synergistically
increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75)." ,
version 0 ,
refs {
pmid 15023809 } ,
create-date
str "Mar 25 2004 12:00AM" ,
update-date
str "Apr 18 2004 7:02AM" } ,
{
type generif ,
text "alpha2-M deletion polymorphism is probably not associated with
functional deficiencies important in Alzheimer's disease pathology" ,
version 0 ,
refs {
pmid 14637088 } ,
create-date
str "Dec 31 2003 12:00AM" ,
update-date
str "Jan 11 2004 7:02AM" } ,
{
type generif ,
text "FGF-2 and this protein interact at specific binding sites,
involving different FGF-2 sequences." ,
version 0 ,
refs {
pmid 12755687 } ,
create-date
str "Sep 7 2003 12:00AM" ,
update-date
str "Sep 28 2003 7:01AM" } ,
{
type generif ,
text "alpha(2)M-derived peptides target the receptor-binding sequence in
TGF-beta" ,
version 0 ,
refs {
pmid 12755614 } ,
create-date
str "Jun 25 2003 12:00AM" ,
update-date
str "Jul 6 2003 7:01AM" } ,
{
type generif ,
text "These results suggest the possible involvement of cathepsin E in
disruption of the structural and functional integrity of alpha
2-macroglobulin in the endolysosome system." ,
version 0 ,
refs {
pmid 12631277 } ,
create-date
str "May 8 2003 12:00AM" ,
update-date
str "May 11 2003 7:01AM" } ,
{
type generif ,
text "Alpha 2-macroglobulin enhances prothrombin activation and thrombin
potential by inhibiting the anticoagulant protein C/protein S system in cord
and adult plasma." ,
version 0 ,
refs {
pmid 12062545 } ,
create-date
str "Feb 6 2003 12:00AM" ,
update-date
str "Aug 17 2003 7:01AM" } ,
{
type generif ,
text "relationship between serum VEGF levels, alpha(2)M levels and the
development of OHSS in hyperstimulated subjects undergoing IVF" ,
version 0 ,
refs {
pmid 12042276 } ,
create-date
str "Dec 16 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:00AM" } ,
{
type generif ,
text "Genetic association of alpha2-macroglobulin polymorphisms with
Alzheimer's disease" ,
version 0 ,
refs {
pmid 12221172 } ,
create-date
str "Sep 27 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "Genetic association of argyrophilic grain disease with
polymorphisms in alpha-2 macroglobulin." ,
version 0 ,
refs {
pmid 12175343 } ,
create-date
str "Sep 24 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "The three-dimensional structure of the dimer reveals its
structural organization in the tetrameric native and chymotrypsin alpha
2-macroglobulin complexes." ,
version 0 ,
refs {
pmid 12015318 } ,
create-date
str "Sep 5 2002 12:00AM" ,
update-date
str "Sep 23 2002 6:27AM" } ,
{
type generif ,
text "has an important role in the AD-specific neurodegenerative process
but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with
late-onset sporadic AD in the Hungarian population" ,
version 0 ,
refs {
pmid 11901360 } ,
create-date
str "Aug 6 2002 12:00AM" ,
update-date
str "Aug 28 2002 6:15PM" } ,
{
type generif ,
text "REVIEW: binds and neutralizes alfimeprase, which has direct
proteolytic activity against the fibrinogen Aalpha chain" ,
version 0 ,
refs {
pmid 11910179 } ,
create-date
str "Jun 12 2002 12:00AM" ,
update-date
str "Sep 7 2003 7:01AM" } ,
{
type generif ,
text "distinct binding sites mediate interaction with beta-amyloid
peptide and growth factors" ,
version 0 ,
refs {
pmid 11823454 } ,
create-date
str "May 4 2002 12:00AM" ,
update-date
str "May 18 2002 6:08AM" } ,
{
type generif ,
text "Differential binding to ldl receptor related protein" ,
version 0 ,
refs {
pmid 11811950 } ,
create-date
str "Feb 14 2002 12:00AM" ,
update-date
str "Mar 4 2002 7:46AM" } ,
{
type generif ,
heading "HIV-1 protein interactions" ,
version 0 ,
comment {
{
type generif ,
text "Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake
and degradation of physiological ligands for LRP, including
alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid
beta-protein" ,
version 0 ,
refs {
pmid 11100124 } ,
comment {
{
type comment ,
label "Tat" ,
accession "NP_057853" ,
version 1 ,
source {
{
src {
db "GeneID" ,
tag
id 155871 } } } } ,
{
type comment ,
accession "NP_000005" ,
version 1 } } ,
create-date
str "May 11 2004 12:48PM" ,
update-date
str "May 11 2004 1:10PM" } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 2 } ,
{
db "MIM" ,
tag
id 103950 } } ,
xtra-index-terms {
"LOC2" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype" } } }