Entrezgene ::= {
track-info {
geneid 1 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 14 ,
hour 13 ,
minute 15 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "19" } } } ,
gene {
locus "A1BG" ,
desc "alpha-1-B glycoprotein" ,
maploc "19q13.4" ,
db {
{
db "MIM" ,
tag
id 138670 } } ,
syn {
"A1B" ,
"ABG" ,
"GAB" ,
"HYST2477" ,
"DKFZp686F0970" } ,
locus-tag "HGNC:5" } ,
prot {
name {
"alpha 1B-glycoprotein" ,
"alpha-1B-glycoprotein" } } ,
summary "The protein encoded by this gene is a plasma glycoprotein of
unknown function. The protein shows sequence similarity to the variable
regions of some immunoglobulin supergene family member proteins." ,
location {
{
display-str "19q13.4" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 1 ,
src-str2 "1" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000019" ,
version 8 ,
seqs {
int {
from 63548355 ,
to 63556668 ,
strand minus ,
id
gi 42406306 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_130786" ,
version 2 ,
genomic-coords {
mix {
int {
from 63548355 ,
to 63550206 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63550530 ,
to 63550817 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63553547 ,
to 63553828 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63554568 ,
to 63554864 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63555460 ,
to 63555732 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63556105 ,
to 63556374 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63556469 ,
to 63556504 ,
strand minus ,
id
gi 42406306 } ,
int {
from 63556581 ,
to 63556668 ,
strand minus ,
id
gi 42406306 } } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_570602" ,
version 2 ,
genomic-coords {
packed-int {
{
from 63550199 ,
to 63550206 ,
strand minus ,
id
gi 42406306 } ,
{
from 63550530 ,
to 63550817 ,
strand minus ,
id
gi 42406306 } ,
{
from 63553547 ,
to 63553828 ,
strand minus ,
id
gi 42406306 } ,
{
from 63554568 ,
to 63554864 ,
strand minus ,
id
gi 42406306 } ,
{
from 63555460 ,
to 63555732 ,
strand minus ,
id
gi 42406306 } ,
{
from 63556105 ,
to 63556374 ,
strand minus ,
id
gi 42406306 } ,
{
from 63556469 ,
to 63556504 ,
strand minus ,
id
gi 42406306 } ,
{
from 63556581 ,
to 63556614 ,
strand minus ,
id
gi 42406306 } } } ,
seqs {
whole
gi 21071030 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_011109" ,
version 15 ,
seqs {
int {
from 31124733 ,
to 31133046 ,
strand minus ,
id
gi 29800594 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_130786" ,
version 2 ,
genomic-coords {
mix {
int {
from 31124733 ,
to 31126584 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31126908 ,
to 31127195 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31129925 ,
to 31130206 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31130946 ,
to 31131242 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31131838 ,
to 31132110 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31132483 ,
to 31132752 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31132847 ,
to 31132882 ,
strand minus ,
id
gi 29800594 } ,
int {
from 31132959 ,
to 31133046 ,
strand minus ,
id
gi 29800594 } } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_570602" ,
version 2 ,
genomic-coords {
packed-int {
{
from 31126577 ,
to 31126584 ,
strand minus ,
id
gi 29800594 } ,
{
from 31126908 ,
to 31127195 ,
strand minus ,
id
gi 29800594 } ,
{
from 31129925 ,
to 31130206 ,
strand minus ,
id
gi 29800594 } ,
{
from 31130946 ,
to 31131242 ,
strand minus ,
id
gi 29800594 } ,
{
from 31131838 ,
to 31132110 ,
strand minus ,
id
gi 29800594 } ,
{
from 31132483 ,
to 31132752 ,
strand minus ,
id
gi 29800594 } ,
{
from 31132847 ,
to 31132882 ,
strand minus ,
id
gi 29800594 } ,
{
from 31132959 ,
to 31132992 ,
strand minus ,
id
gi 29800594 } } } ,
seqs {
whole
gi 21071030 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_086907" ,
version 1 ,
seqs {
int {
from 8163589 ,
to 8172398 ,
strand minus ,
id
gi 51475048 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_130786" ,
version 2 ,
genomic-coords {
mix {
int {
from 8163589 ,
to 8165440 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8165763 ,
to 8166050 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8169274 ,
to 8169555 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8170297 ,
to 8170593 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8171190 ,
to 8171462 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8171835 ,
to 8172104 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8172199 ,
to 8172234 ,
strand minus ,
id
gi 51475048 } ,
int {
from 8172311 ,
to 8172398 ,
strand minus ,
id
gi 51475048 } } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_570602" ,
version 2 ,
genomic-coords {
packed-int {
{
from 8165433 ,
to 8165440 ,
strand minus ,
id
gi 51475048 } ,
{
from 8165763 ,
to 8166050 ,
strand minus ,
id
gi 51475048 } ,
{
from 8169274 ,
to 8169555 ,
strand minus ,
id
gi 51475048 } ,
{
from 8170297 ,
to 8170593 ,
strand minus ,
id
gi 51475048 } ,
{
from 8171190 ,
to 8171462 ,
strand minus ,
id
gi 51475048 } ,
{
from 8171835 ,
to 8172104 ,
strand minus ,
id
gi 51475048 } ,
{
from 8172199 ,
to 8172234 ,
strand minus ,
id
gi 51475048 } ,
{
from 8172311 ,
to 8172344 ,
strand minus ,
id
gi 51475048 } } } ,
seqs {
whole
gi 21071030 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "A1BG" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "alpha-1-B glycoprotein" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "GOA" ,
url "http://www.ebi.ac.uk/GOA/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 3458201 } ,
source {
{
src {
db "GO" ,
tag
id 5554 } ,
anchor "molecular_function unknown" ,
post-text "evidence: ND" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 4 } ,
anchor "biological_process unknown" ,
post-text "evidence: ND" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 3458201 } ,
source {
{
src {
db "GO" ,
tag
id 5576 } ,
anchor "extracellular region" ,
post-text "evidence: IDA" } } } } } } } } ,
homology {
{
type comment ,
heading "Mouse, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 11167 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=19&
MAPS=genes-r-org/rat-chr/human%3A19,genes-r-org/mouse-chr/human%3A19,genes-r-o
rg/human-chr19&query=e%3A1[id]+AND+gene[obj_type]&QSTR=a1bg&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "HGNC" ,
tag
id 5 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15461460 ,
pmid 15221005 ,
pmid 14702039 ,
pmid 12477932 ,
pmid 8889549 ,
pmid 3610142 ,
pmid 3458201 ,
pmid 2591067 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 89991 } ,
anchor "SHGC-67307" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "RH80032" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH86145" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 152074 } ,
anchor "D11S2921" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "GDB:461809" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 155756 } ,
anchor "D10S16" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "D10S23" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "GDB:193809" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_130786" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 21071029 } ,
anchor "NM_130786" } } ,
seqs {
whole
gi 21071029 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_570602" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 21071030 } ,
anchor "NP_570602" ,
post-text "alpha 1B-glycoprotein" } } ,
seqs {
whole
gi 21071030 } ,
comment {
{
type other ,
heading "Consensus CDS (CCDS)" ,
version 0 ,
source {
{
src {
db "CCDS" ,
tag
str "CCDS12976.1" } ,
anchor "CCDS12976.1" } } } ,
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 21071030 } ,
pre-text "(1)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 365 } ,
anchor "smart00408: IGc2; Immunoglobulin C-2 Type" } } ,
comment {
{
type other ,
text "Location: 223 - 282 Blast Score: 103" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "AF414429,AK055885,AK056201" } ,
anchor "AF414429,AK055885,AK056201" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "AC010642" ,
version 5 ,
source {
{
src {
db "Nucleotide" ,
tag
id 9929687 } ,
anchor "AC010642" } } ,
seqs {
int {
from 41119 ,
to 43581 ,
strand plus ,
id
gi 9929687 } } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AB073611" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 51555784 } ,
anchor "AB073611" } } ,
seqs {
whole
gi 51555784 } ,
products {
{
type peptide ,
accession "BAD38648" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 51555785 } ,
anchor "BAD38648" } } ,
seqs {
whole
gi 51555785 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AF414429" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 15778555 } ,
anchor "AF414429" } } ,
seqs {
whole
gi 15778555 } ,
products {
{
type peptide ,
accession "AAL07469" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 15778556 } ,
anchor "AAL07469" } } ,
seqs {
whole
gi 15778556 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK055885" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 16550723 } ,
anchor "AK055885" } } ,
seqs {
whole
gi 16550723 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK056201" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 16551539 } ,
anchor "AK056201" } } ,
seqs {
whole
gi 16551539 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC035719" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 23273475 } ,
anchor "BC035719" } } ,
seqs {
whole
gi 23273475 } ,
products {
{
type peptide ,
accession "AAH35719" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 23273476 } ,
anchor "AAH35719" } } ,
seqs {
whole
gi 23273476 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BX537419" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 31873339 } ,
anchor "BX537419" } } ,
seqs {
whole
gi 31873339 } ,
products {
{
type peptide ,
accession "CAD97661" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 31873340 } ,
anchor "CAD97661" } } ,
seqs {
whole
gi 31873340 } } } } ,
{
type other ,
text "None" ,
version 0 ,
products {
{
type peptide ,
accession "P04217" ,
version 0 ,
source {
{
src {
db "Protein" ,
tag
id 46577680 } ,
anchor "P04217" } } ,
seqs {
whole
gi 46577680 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "1" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
g=NT_011109.15&gene=A1BG&lid=1&from=31124734&to=31133047" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "1" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
06&contig=NT_011109.15&gene=A1BG&lid=1" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Hs.529161" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Hs.529161" } ,
anchor "Hs.529161" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=52
9161" } } } ,
{
type comment ,
text "MIM" ,
version 0 ,
source {
{
src {
db "MIM" ,
tag
str "138670" } ,
anchor "138670" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "1" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
1[loc]&TAXID=9606" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "AceView" ,
tag
id 1 } ,
anchor "AceView" ,
url "http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
ocusid&org=9606&l=1" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GDB" ,
tag
str "GDB:119638" } } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Homo_sapiens/contigview?geneid=AK055
885" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
AK055885" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC035719" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC035719" } } } } } ,
{
type generif ,
text "A1BG-cysteine-rich secretory protein 3 complex displays a similar
function in protecting the circulation from a potentially harmful effect of
free CRISP-3" ,
version 0 ,
refs {
pmid 15461460 } ,
create-date
str "Nov 6 2004 10:01AM" ,
update-date
str "Nov 6 2004 3:27PM" } } ,
unique-keys {
{
db "LocusID" ,
tag
id 1 } ,
{
db "MIM" ,
tag
id 138670 } } ,
xtra-index-terms {
"LOC1" } }
Entrezgene ::= {
track-info {
geneid 2 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 14 ,
hour 13 ,
minute 15 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "12" } } } ,
gene {
locus "A2M" ,
desc "alpha-2-macroglobulin" ,
maploc "12p13.3-p12.3" ,
db {
{
db "MIM" ,
tag
id 103950 } } ,
syn {
"FWP007" ,
"S863-7" ,
"DKFZp779B086" } ,
locus-tag "HGNC:7" } ,
prot {
name {
"alpha-2-macroglobulin" } } ,
summary "Alpha-2-macroglobulin is a protease inhibitor and cytokine
transporter. It inhibits many proteases, including trypsin, thrombin and
collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability
to mediate the clearance and degradation of A-beta, the major component of
beta-amyloid deposits." ,
location {
{
display-str "12p13.3-p12.3" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 2 ,
src-str2 "2" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000012" ,
version 9 ,
seqs {
int {
from 9111576 ,
to 9159755 ,
strand minus ,
id
gi 51511728 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_000014" ,
version 3 ,
genomic-coords {
mix {
int {
from 9111576 ,
to 9111701 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9112045 ,
to 9112086 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9112602 ,
to 9112704 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9113607 ,
to 9113675 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9114350 ,
to 9114440 ,
strand minus ,
id
gi 51511728 } ,
int {
from 9116221 ,
to 9116348 ,
strand minus ,
id
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products {
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gi 6226959 } ,
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properties {
{
type comment ,
label "Nomenclature" ,
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source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
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text "A2M" ,
version 0 } ,
{
type property ,
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version 0 } } } ,
{
type comment ,
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source {
{
pre-text "Provided by" ,
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comment {
{
type comment ,
label "Function" ,
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comment {
{
type comment ,
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source {
{
src {
db "GO" ,
tag
id 19899 } ,
anchor "enzyme binding" ,
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{
type comment ,
version 0 ,
refs {
pmid 9714181 } ,
source {
{
src {
db "GO" ,
tag
id 19966 } ,
anchor "interleukin-1 binding" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10880251 } ,
source {
{
src {
db "GO" ,
tag
id 19959 } ,
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post-text "evidence: IPI" } } } ,
{
type comment ,
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source {
{
src {
db "GO" ,
tag
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{
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tag "UNIGENE" ,
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src {
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src {
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src {
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type comment ,
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src {
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source {
{
src {
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src {
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src {
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src {
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src {
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src {
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anchor "MGC" ,
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{
type comment ,
heading "Pathways" ,
version 0 ,
comment {
{
type comment ,
text "KEGG pathway: Alzheimer's disease" ,
version 0 ,
source {
{
src {
db "05010" ,
tag
str "05010" } ,
anchor "05010" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa05010+2" } } } ,
{
type comment ,
text "KEGG pathway: Coagulation cascade" ,
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source {
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src {
db "04610" ,
tag
str "04610" } ,
anchor "04610" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
{
type comment ,
text "KEGG pathway: Complement and coagulation cascades" ,
version 0 ,
source {
{
src {
db "04610" ,
tag
str "04610" } ,
anchor "04610" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa04610+2" } } } ,
{
type comment ,
text "Reactome: Hemostasis" ,
version 0 ,
source {
{
anchor "49292" ,
url "http://www.reactome.org/cgi-bin/link?SOURCE=UniProt&ID=P010
23" } } } } } ,
{
type generif ,
text "an important involvement of alpha2M in regulation of increased
proteolytic activity occurring in multiple sclerosis disease" ,
version 0 ,
refs {
pmid 15511627 } ,
create-date
str "Dec 18 2004 10:01AM" ,
update-date
str "Dec 18 2004 1:19PM" } ,
{
type generif ,
text "alpha2-macroglobulin inhibits human pepsin and gastricsin" ,
version 0 ,
refs {
pmid 14506912 } ,
create-date
str "Oct 7 2003 12:00AM" ,
update-date
str "Jul 7 2004 1:36PM" } ,
{
type generif ,
text "There is a significant genetic association of the 5 bp deletion
and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin
precursor with AD" ,
version 0 ,
refs {
pmid 12966032 } ,
create-date
str "Jun 27 2004 5:41PM" ,
update-date
str "Jun 27 2004 6:18PM" } ,
{
type generif ,
text "Alpha2-macroglobulin is a substrate and an endogenous inhibitor
for ADAMTS-4 and ADAMTS-5" ,
version 0 ,
refs {
pmid 14715656 } ,
create-date
str "Jun 14 2004 4:41PM" ,
update-date
str "Jun 14 2004 5:44PM" } ,
{
type generif ,
text "A2M-D allele played a weak Alzheimer disease protective role, and
APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk
for mainland Han Chinese." ,
version 0 ,
refs {
pmid 14675603 } ,
create-date
str "Feb 17 2004 12:00AM" ,
update-date
str "Apr 13 2004 1:35PM" } ,
{
type generif ,
text "Plasma from patients homozygous for the intronic deletion (DD)
showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory
activity. Plasma alpha(2)M from two DD patients showed markedly increased
TGF-beta1 binding." ,
version 0 ,
refs {
pmid 14678766 } ,
create-date
str "Jan 20 2004 12:00AM" ,
update-date
str "Mar 7 2004 7:01AM" } ,
{
type generif ,
text "The presence of MPO-G/G and A2M-Val/Val genotypes synergistically
increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75)." ,
version 0 ,
refs {
pmid 15023809 } ,
create-date
str "Mar 25 2004 12:00AM" ,
update-date
str "Apr 18 2004 7:02AM" } ,
{
type generif ,
text "alpha2-M deletion polymorphism is probably not associated with
functional deficiencies important in Alzheimer's disease pathology" ,
version 0 ,
refs {
pmid 14637088 } ,
create-date
str "Dec 31 2003 12:00AM" ,
update-date
str "Jan 11 2004 7:02AM" } ,
{
type generif ,
text "FGF-2 and this protein interact at specific binding sites,
involving different FGF-2 sequences." ,
version 0 ,
refs {
pmid 12755687 } ,
create-date
str "Sep 7 2003 12:00AM" ,
update-date
str "Sep 28 2003 7:01AM" } ,
{
type generif ,
text "alpha(2)M-derived peptides target the receptor-binding sequence in
TGF-beta" ,
version 0 ,
refs {
pmid 12755614 } ,
create-date
str "Jun 25 2003 12:00AM" ,
update-date
str "Jul 6 2003 7:01AM" } ,
{
type generif ,
text "These results suggest the possible involvement of cathepsin E in
disruption of the structural and functional integrity of alpha
2-macroglobulin in the endolysosome system." ,
version 0 ,
refs {
pmid 12631277 } ,
create-date
str "May 8 2003 12:00AM" ,
update-date
str "May 11 2003 7:01AM" } ,
{
type generif ,
text "Alpha 2-macroglobulin enhances prothrombin activation and thrombin
potential by inhibiting the anticoagulant protein C/protein S system in cord
and adult plasma." ,
version 0 ,
refs {
pmid 12062545 } ,
create-date
str "Feb 6 2003 12:00AM" ,
update-date
str "Aug 17 2003 7:01AM" } ,
{
type generif ,
text "relationship between serum VEGF levels, alpha(2)M levels and the
development of OHSS in hyperstimulated subjects undergoing IVF" ,
version 0 ,
refs {
pmid 12042276 } ,
create-date
str "Dec 16 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:00AM" } ,
{
type generif ,
text "Genetic association of alpha2-macroglobulin polymorphisms with
Alzheimer's disease" ,
version 0 ,
refs {
pmid 12221172 } ,
create-date
str "Sep 27 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "Genetic association of argyrophilic grain disease with
polymorphisms in alpha-2 macroglobulin." ,
version 0 ,
refs {
pmid 12175343 } ,
create-date
str "Sep 24 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "The three-dimensional structure of the dimer reveals its
structural organization in the tetrameric native and chymotrypsin alpha
2-macroglobulin complexes." ,
version 0 ,
refs {
pmid 12015318 } ,
create-date
str "Sep 5 2002 12:00AM" ,
update-date
str "Sep 23 2002 6:27AM" } ,
{
type generif ,
text "has an important role in the AD-specific neurodegenerative process
but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with
late-onset sporadic AD in the Hungarian population" ,
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refs {
pmid 11901360 } ,
create-date
str "Aug 6 2002 12:00AM" ,
update-date
str "Aug 28 2002 6:15PM" } ,
{
type generif ,
text "REVIEW: binds and neutralizes alfimeprase, which has direct
proteolytic activity against the fibrinogen Aalpha chain" ,
version 0 ,
refs {
pmid 11910179 } ,
create-date
str "Jun 12 2002 12:00AM" ,
update-date
str "Sep 7 2003 7:01AM" } ,
{
type generif ,
text "distinct binding sites mediate interaction with beta-amyloid
peptide and growth factors" ,
version 0 ,
refs {
pmid 11823454 } ,
create-date
str "May 4 2002 12:00AM" ,
update-date
str "May 18 2002 6:08AM" } ,
{
type generif ,
text "Differential binding to ldl receptor related protein" ,
version 0 ,
refs {
pmid 11811950 } ,
create-date
str "Feb 14 2002 12:00AM" ,
update-date
str "Mar 4 2002 7:46AM" } ,
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{
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pmid 11100124 } ,
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prot {
name {
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location {
{
display-str "8p23.1-p21.3" ,
method
map-type cyto } } ,
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{
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{
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{
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anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC047666" } } } } } ,
{
type generif ,
text "In breast, NAT1 mRNA is transcribed from a strong promoter located
11.8 kb upstream of the translated exon, and the mature spliced mRNA includes
at least one additional non-coding exon." ,
version 0 ,
refs {
pmid 15226672 } ,
create-date
str "Mar 26 2005 10:01AM" ,
update-date
str "Mar 26 2005 1:53PM" } ,
{
type generif ,
text "Polymorphism at the NAT1 locus has been associated with the
existence of at least 26 allelic variants, generating phenotypic variations
in terms NAT-1 catalytic activity. This genetic variation affects the
acetylator status of individuals." ,
version 0 ,
refs {
pmid 15320760 } ,
create-date
str "Dec 18 2004 10:01AM" ,
update-date
str "Mar 17 2005 6:52AM" } ,
{
type generif ,
text "NAT1 exists in the cell in either a stable acetylated state or an
unstable non-acetylated state and mutations in the NAT1 gene that prevent
protein acetylation produce a slow acetylator phenotype" ,
version 0 ,
refs {
pmid 15039438 } ,
create-date
str "Jul 6 2004 11:50AM" ,
update-date
str "Jul 6 2004 12:11PM" } ,
{
type generif ,
text "Analysis of the effect of active NAT-1 overexpression in a normal
luminal epithelial-derived cell line demonstrated enhanced growth properties
and etoposide resistance relative to control cells." ,
version 0 ,
refs {
pmid 14517345 } ,
create-date
str "Jun 23 2004 4:43PM" ,
update-date
str "Jun 23 2004 5:16PM" } ,
{
type generif ,
text "cellular generation of peroxynitrite may contribute to
carcinogenesis and tumor progression by weakening key cellular defense
enzymes such as arylamine N-acetyltransferase 1 (NAT1)" ,
version 0 ,
refs {
pmid 14672957 } ,
create-date
str "Mar 24 2004 12:00AM" ,
update-date
str "May 9 2004 7:01AM" } ,
{
type generif ,
text "although there is little overall association between NAT genotypes
and risk of developing systemic lupus erythematosus, the interaction between
NAT1 and NAT2 and specific exposures such as hair dyes may be important." ,
version 0 ,
refs {
pmid 14705222 } ,
create-date
str "Apr 16 2004 12:00AM" ,
update-date
str "May 2 2004 7:01AM" } ,
{
type generif ,
text "A putative RUNX1 binding site variant of NAT9 is associated with
susceptibility to psoriasis" ,
version 0 ,
refs {
pmid 14608357 } ,
create-date
str "Dec 18 2003 12:00AM" ,
update-date
str "Jan 11 2004 7:03AM" } ,
{
type generif ,
text "Identification of minimal promoter sequences for transcription
factor binding sites in the human N-acetyltransferase Type I gene. that binds" ,
version 0 ,
refs {
pmid 12946272 } ,
create-date
str "Nov 24 2003 12:00AM" ,
update-date
str "Dec 7 2003 7:02AM" } ,
{
type generif ,
text "Oxidative stress and cellular redox status may regulate NAT1
activity and have important consequences with regard to drug
biotransformation and cancer risk." ,
version 0 ,
refs {
pmid 12832400 } ,
create-date
str "Oct 7 2003 12:00AM" ,
update-date
str "Nov 16 2003 7:02AM" } ,
{
type generif ,
text "Variation in capacity for acetylation of 4ABP and PABA resulting
from human NAT1 transgene is insufficient to affect 4ABP genotoxicity in
mouse liver." ,
version 0 ,
refs {
pmid 12902152 } ,
create-date
str "Sep 6 2003 12:00AM" ,
update-date
str "Sep 14 2003 7:01AM" } ,
{
type generif ,
text "It is unlikely that the NAT1*10 or NAT2 rapid/intermediate
genotypes are related to stomach cancer risk." ,
version 0 ,
refs {
pmid 12692115 } ,
create-date
str "Sep 4 2003 12:00AM" ,
update-date
str "Sep 28 2003 7:01AM" } ,
{
type generif ,
text "genetic polymorphisms of NAT1 and NAT2 have no independent effect
on breast cancer risk, but they modulate breast cancer risk in the presence
of GSTM1 and GSTT1 null genotypes." ,
version 0 ,
refs {
pmid 12860276 } ,
create-date
str "Aug 18 2003 12:00AM" ,
update-date
str "Aug 24 2003 7:01AM" } ,
{
type generif ,
text "NAT1 * 10 has increased risk of sporadic colorectal adenocarcinoma
and significantly related to the later stage tumors, is not significantly
related to the tumor location" ,
version 0 ,
refs {
pmid 12485520 } ,
create-date
str "Jun 25 2003 12:00AM" ,
update-date
str "Jul 13 2003 7:01AM" } ,
{
type generif ,
text "Single nucleotide polymorphisms of NAT1 and NAT2, and acetylation
haplotype were not associated with increased risk for Parkinson disease" ,
version 0 ,
refs {
pmid 12682333 } ,
create-date
str "Apr 11 2003 12:00AM" ,
update-date
str "Apr 27 2003 7:01AM" } ,
{
type generif ,
text "NAT1 polymorphism (NAT1*10) indicates increased susceptibility to
prostate cancer" ,
version 0 ,
refs {
pmid 12355549 } ,
create-date
str "Oct 31 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:01AM" } ,
{
type generif ,
text "susceptibility gene for multifactorial adverse effects and
xenobiotic-related diseases (review)" ,
version 0 ,
refs {
pmid 12052143 } ,
create-date
str "Sep 12 2002 12:00AM" ,
update-date
str "Sep 16 2002 5:48AM" } ,
{
type generif ,
text "NAT1 genotype acts as a modifier of diisothionate
exposure-associated asthma risk" ,
version 0 ,
refs {
pmid 11927838 } ,
create-date
str "Aug 30 2002 12:00AM" ,
update-date
str "Sep 16 2002 5:48AM" } ,
{
type generif ,
text "NAT1 polymorphisms may be correlated with an increased risk of
larynx cancer" ,
version 0 ,
refs {
pmid 12037388 } ,
create-date
str "Aug 19 2002 12:00AM" ,
update-date
str "Aug 28 2002 6:15PM" } ,
{
type generif ,
text "paclitaxel affected human leukemia HL-60 cells arylamine
N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adduct formation." ,
version 0 ,
refs {
pmid 11955677 } ,
create-date
str "Jun 19 2002 12:00AM" ,
update-date
str "Jun 24 2002 6:31AM" } ,
{
type generif ,
text "paclitaxel is an uncompetitive inhibitor to arylamine
N-acetyltransferase (NAT) enzyme" ,
version 0 ,
refs {
pmid 11955676 } ,
create-date
str "Jun 19 2002 12:00AM" ,
update-date
str "Jun 24 2002 6:31AM" } } ,
unique-keys {
{
db "LocusID" ,
tag
id 9 } ,
{
db "MIM" ,
tag
id 108345 } } ,
xtra-index-terms {
"LOC9" } }
Entrezgene ::= {
track-info {
geneid 10 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 17 ,
hour 11 ,
minute 9 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "8" } } } ,
gene {
locus "NAT2" ,
desc "N-acetyltransferase 2 (arylamine N-acetyltransferase)" ,
maploc "8p22" ,
db {
{
db "MIM" ,
tag
id 243400 } } ,
syn {
"AAC2" } ,
locus-tag "HGNC:7646" } ,
prot {
name {
"arylamide acetylase 2" ,
"Arylamine N-acetyltransferase-2" ,
"arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation)" } } ,
summary "The intronless NAT2 gene encodes N-acetyltransferase 2 (arylamine
N-acetyltransferase 2). This enzyme functions to both activate and deactivate
arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are
reponsible for the N-acetylation polymorphism in which human populations
segregate into rapid,intermediate, and slow acetylator phenotypes.
Polymorphisms in NAT2 are also associated with higher incidences of cancer
and drug toxicity.A second arylamine N-acetyltransferase gene (NAT1) is
located near NAT2." ,
location {
{
display-str "8p22" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 10 ,
src-str2 "10" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000008" ,
version 9 ,
seqs {
int {
from 18293034 ,
to 18302961 ,
strand plus ,
id
gi 51511724 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_000015" ,
version 1 ,
genomic-coords {
mix {
int {
from 18293034 ,
to 18293134 ,
strand plus ,
id
gi 51511724 } ,
int {
from 18301787 ,
to 18302961 ,
strand plus ,
id
gi 51511724 } } } ,
seqs {
whole
gi 4557782 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_000006" ,
version 1 ,
genomic-coords {
int {
from 18301793 ,
to 18302665 ,
strand plus ,
id
gi 51511724 } } ,
seqs {
whole
gi 4557783 } ,
comment {
{
type property ,
label "EC" ,
text "2.3.1.5" ,
version 0 ,
xtra-properties {
{
tag "EC" ,
value "2.3.1.5" } } } } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_030737" ,
version 9 ,
seqs {
int {
from 6093682 ,
to 6103609 ,
strand plus ,
id
gi 51466871 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_000015" ,
version 1 ,
genomic-coords {
mix {
int {
from 6093682 ,
to 6093782 ,
strand plus ,
id
gi 51466871 } ,
int {
from 6102435 ,
to 6103609 ,
strand plus ,
id
gi 51466871 } } } ,
seqs {
whole
gi 4557782 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_000006" ,
version 1 ,
genomic-coords {
int {
from 6102441 ,
to 6103313 ,
strand plus ,
id
gi 51466871 } } ,
seqs {
whole
gi 4557783 } ,
comment {
{
type property ,
label "EC" ,
text "2.3.1.5" ,
version 0 ,
xtra-properties {
{
tag "EC" ,
value "2.3.1.5" } } } } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_086740" ,
version 1 ,
seqs {
int {
from 5773920 ,
to 5783845 ,
strand plus ,
id
gi 51467159 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_000015" ,
version 1 ,
genomic-coords {
mix {
int {
from 5773920 ,
to 5774020 ,
strand plus ,
id
gi 51467159 } ,
int {
from 5782671 ,
to 5783845 ,
strand plus ,
id
gi 51467159 } } } ,
seqs {
whole
gi 4557782 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_000006" ,
version 1 ,
genomic-coords {
int {
from 5782677 ,
to 5783549 ,
strand plus ,
id
gi 51467159 } } ,
seqs {
whole
gi 4557783 } ,
comment {
{
type property ,
label "EC" ,
text "2.3.1.5" ,
version 0 ,
xtra-properties {
{
tag "EC" ,
value "2.3.1.5" } } } } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "NAT2" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "N-acetyltransferase 2 (arylamine N-acetyltransferase)" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "GOA" ,
url "http://www.ebi.ac.uk/GOA/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16407 } ,
anchor "acetyltransferase activity" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 2340091 } ,
source {
{
src {
db "GO" ,
tag
id 4060 } ,
anchor "arylamine N-acetyltransferase activity" ,
post-text "evidence: TAS" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16740 } ,
anchor "transferase activity" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 8152 } ,
anchor "metabolism" ,
post-text "evidence: IEA" } } } } } } } } ,
homology {
{
type comment ,
heading "Mouse, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 32047 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=8&M
APS=genes-r-org/rat-chr/human%3A8,genes-r-org/mouse-chr/human%3A8,genes-r-org/
human-chr8&query=e%3A10[id]+AND+gene[obj_type]&QSTR=nat2&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "HGNC" ,
tag
id 7646 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15671210 ,
pmid 15637738 ,
pmid 15609332 ,
pmid 15588473 ,
pmid 15225898 ,
pmid 15162844 ,
pmid 15005011 ,
pmid 14747882 ,
pmid 14705222 ,
pmid 14648207 ,
pmid 14618622 ,
pmid 14528063 ,
pmid 12884528 ,
pmid 12877350 ,
pmid 12860276 ,
pmid 12835615 ,
pmid 12773763 ,
pmid 12760253 ,
pmid 12724621 ,
pmid 12692115 ,
pmid 12682333 ,
pmid 12654968 ,
pmid 12622714 ,
pmid 12611196 ,
pmid 12477932 ,
pmid 12474054 ,
pmid 12469231 ,
pmid 12465141 ,
pmid 12430181 ,
pmid 12397635 ,
pmid 12360107 ,
pmid 12355549 ,
pmid 12235453 ,
pmid 12222688 ,
pmid 12163321 ,
pmid 12037388 ,
pmid 12016157 ,
pmid 12015038 ,
pmid 11915035 ,
pmid 11872636 ,
pmid 11846845 ,
pmid 11470991 ,
pmid 9202751 ,
pmid 8460648 ,
pmid 8110178 ,
pmid 8102597 ,
pmid 7915226 ,
pmid 7902079 ,
pmid 7773298 ,
pmid 2734109 ,
pmid 2340091 ,
pmid 2068113 ,
pmid 1996083 ,
pmid 1968463 ,
pmid 1676262 ,
pmid 1441598 ,
pmid 1381364 ,
pmid 1306121 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 17088 } ,
anchor "G06461" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "WI-7224" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 44576 } ,
anchor "WIAF-2120" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "RH11442" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH20" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "WIAF-2120-STS" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "gdb:4559542" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "stSG40" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 137181 } ,
anchor "G59899" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "SHGC-130680" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 155563 } ,
anchor "GDB:187676" ,
post-text "(e-PCR)" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 156422 } ,
anchor "GDB:310612" ,
post-text "(e-PCR)" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 156423 } ,
anchor "GDB:310613" ,
post-text "(e-PCR)" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 157141 } ,
anchor "GDB:386004" ,
post-text "(e-PCR)" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 272646 } ,
anchor "PMC310725P3" ,
post-text "(e-PCR)" } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_000015" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 4557782 } ,
anchor "NM_000015" } } ,
seqs {
whole
gi 4557782 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_000006" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 4557783 } ,
anchor "NP_000006" ,
post-text "arylamide acetylase 2" } } ,
seqs {
whole
gi 4557783 } ,
comment {
{
type other ,
heading "Consensus CDS (CCDS)" ,
version 0 ,
source {
{
src {
db "CCDS" ,
tag
str "CCDS6008.1" } ,
anchor "CCDS6008.1" } } } ,
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 4557783 } ,
pre-text "(1)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 1353 } ,
anchor "pfam00797: Acetyltransf_2;
N-acetyltransferase" } } ,
comment {
{
type other ,
text "Location: 20 - 280 Blast Score: 1005" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "D90042" } ,
anchor "D90042" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "AF042740" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 2801806 } ,
anchor "AF042740" } } ,
seqs {
whole
gi 2801806 } ,
products {
{
type peptide ,
accession "AAC03773" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 2801807 } ,
anchor "AAC03773" } } ,
seqs {
whole
gi 2801807 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AF055874" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 3063613 } ,
anchor "AF055874" } } ,
seqs {
whole
gi 3063613 } ,
products {
{
type peptide ,
accession "AAC14117" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 3063614 } ,
anchor "AAC14117" } } ,
seqs {
whole
gi 3063614 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AF055875" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 3063615 } ,
anchor "AF055875" } } ,
seqs {
whole
gi 3063615 } ,
products {
{
type peptide ,
accession "AAC14118" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 3063616 } ,
anchor "AAC14118" } } ,
seqs {
whole
gi 3063616 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AF320309" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 11321494 } ,
anchor "AF320309" } } ,
seqs {
whole
gi 11321494 } ,
products {
{
type peptide ,
accession "AAG34181" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 11321495 } ,
anchor "AAG34181" } } ,
seqs {
whole
gi 11321495 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AF348074" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 14009675 } ,
anchor "AF348074" } } ,
seqs {
whole
gi 14009675 } ,
products {
{
type peptide ,
accession "AAK51710" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 14009676 } ,
anchor "AAK51710" } } ,
seqs {
whole
gi 14009676 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AF348075" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 14009677 } ,
anchor "AF348075" } } ,
seqs {
whole
gi 14009677 } ,
products {
{
type peptide ,
accession "AAK51711" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 14009678 } ,
anchor "AAK51711" } } ,
seqs {
whole
gi 14009678 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AY230251" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 29423785 } ,
anchor "AY230251" } } ,
seqs {
whole
gi 29423785 } ,
products {
{
type peptide ,
accession "AAO73561" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 29423786 } ,
anchor "AAO73561" } } ,
seqs {
whole
gi 29423786 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AY230252" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 29423789 } ,
anchor "AY230252" } } ,
seqs {
whole
gi 29423789 } ,
products {
{
type peptide ,
accession "AAO73562" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 29423790 } ,
anchor "AAO73562" } } ,
seqs {
whole
gi 29423790 } } } } ,
{
type genomic ,
heading "Genomic" ,
accession "AY331807" ,
version 1 ,
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{
type other ,
text "None" ,
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products {
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{
type comment ,
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type comment ,
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{
src {
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tag
str "10" } ,
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{
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{
type comment ,
text "UniGene" ,
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tag "UNIGENE" ,
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source {
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src {
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{
type comment ,
text "MIM" ,
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{
src {
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str "243400" } ,
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{
type comment ,
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{
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{
src {
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tag
str "GDB:125365" } } } } ,
{
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{
src {
db "Ensembl" ,
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{
type comment ,
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{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
BC067218" } } } ,
{
type comment ,
text "PharmGKB" ,
version 0 ,
source {
{
src {
db "PharmGKB" ,
tag
str "PA18" } ,
anchor "PA18" } } } ,
{
type comment ,
text "Arylamine N-Acetyltransferase Nomenclature" ,
version 0 ,
source {
{
src {
db "Arylamine N-Acetyltransferase Nomenclature" ,
tag
str "Arylamine N-Acetyltransferase Nomenclature" } ,
anchor "Arylamine N-Acetyltransferase Nomenclature" ,
url "http://www.louisville.edu/medschool/pharmacology/NAT.html" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC015878,BC067218" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC015878
,BC067218" } } } } } ,
{
type generif ,
text "there is no association between endometriosis and NAT2 in South
Indian women" ,
version 0 ,
refs {
pmid 15588473 } ,
create-date
str "Mar 19 2005 10:01AM" ,
update-date
str "Mar 19 2005 11:47AM" } ,
{
type generif ,
text "Risks for colorectal cancer are significantly associated with the
genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and
genotye and NAT2-rapid acetylator phenotype." ,
version 0 ,
refs {
pmid 15637738 } ,
create-date
str "Mar 7 2005 7:07PM" ,
update-date
str "Mar 8 2005 12:10AM" } ,
{
type generif ,
text "Cigarette smoking is associated with increased risk of breast
cancer in women with the NAT2 slow acetylator genotype." ,
version 0 ,
refs {
pmid 15225898 } ,
create-date
str "Nov 13 2004 10:01AM" ,
update-date
str "Nov 13 2004 10:50AM" } ,
{
type generif ,
text "N-acetyltransferase 2 polymorphism does not play an important role
in breast cancer risk of Turkish women by altering the capacity in
deactivation of environmental carcinogens" ,
version 0 ,
refs {
pmid 15162844 } ,
create-date
str "Oct 4 2004 10:33AM" ,
update-date
str "Oct 4 2004 11:19AM" } ,
{
type generif ,
text "NAT2 slow acetylator genotypes might modulate the effect of
carcinogenic arylamines contained in tobacco smoke." ,
version 0 ,
refs {
pmid 14648207 } ,
create-date
str "Sep 27 2004 4:34PM" ,
update-date
str "Sep 27 2004 5:11PM" } ,
{
type generif ,
text "Arylamine N-acetyltransferase 2 is a genetically polymorphic phase
II enzyme with a role in the metabolism of many xenobiotics." ,
version 0 ,
refs {
pmid 14747882 } ,
create-date
str "Aug 2 2004 1:09PM" ,
update-date
str "Aug 2 2004 1:38PM" } ,
{
type generif ,
text "although there is little overall association between NAT genotypes
and risk of developing systemic lupus erythematosus, the interaction between
NAT1 and NAT2 and specific exposures such as hair dyes may be important" ,
version 0 ,
refs {
pmid 14705222 } ,
create-date
str "Apr 16 2004 12:00AM" ,
update-date
str "May 2 2004 7:01AM" } ,
{
type generif ,
text "The NAT2 acetylator genotype may modify esophageal cancer risk in
humans from exposure to barbecued/grilled meat." ,
version 0 ,
refs {
pmid 12773763 } ,
create-date
str "Feb 13 2004 12:00AM" ,
update-date
str "Feb 22 2004 7:01AM" } ,
{
type generif ,
text "N-acetyltransferase 2 polymorphism does not differ between
patients suffering from atopic dermatitis and healthy subjects" ,
version 0 ,
refs {
pmid 14528063 } ,
create-date
str "Feb 5 2004 12:00AM" ,
update-date
str "Feb 15 2004 6:33PM" } ,
{
type generif ,
text "Genetic NAT2 polymorphism may play a role in lifestyle
factors-related hepato- carcinogenesis, particulary critical in smoking
related hepatocarcinogenesis." ,
version 0 ,
refs {
pmid 12877350 } ,
create-date
str "Feb 4 2004 12:00AM" ,
update-date
str "Feb 15 2004 6:32PM" } ,
{
type generif ,
text "Slow acetylation activity is associated with age-related cataract
formation." ,
version 0 ,
refs {
pmid 12724621 } ,
create-date
str "Jan 6 2004 12:00AM" ,
update-date
str "Feb 22 2004 7:01AM" } ,
{
type generif ,
text "A significant association between Parkinson disease & the slow
acetylator genotype for N-acetyltransferase 2 in Hong Kong Chinesed provides
evidence for a possible functional relationship between NAT2 slow acetylator
genotype & PD in both racial groups." ,
version 0 ,
refs {
pmid 12654968 } ,
create-date
str "Dec 23 2003 12:00AM" ,
update-date
str "Jan 18 2004 7:01AM" } ,
{
type generif ,
text "RFLP of the gene coding for N-acetyltransferase 2 (NAT2) was typed
in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes,
Udmurts, and Russians) and in patients with chronic obstructive pulmonary
disease (COPD) and in healthy individuals" ,
version 0 ,
refs {
pmid 12884528 } ,
create-date
str "Dec 18 2003 12:00AM" ,
update-date
str "Jan 25 2004 7:01AM" } ,
{
type generif ,
text "We conclude that smoking increases risk of colorectal adenomas and
that SULT1A1 and NAT2 only modestly modify this association." ,
version 0 ,
refs {
pmid 14618622 } ,
create-date
str "Dec 11 2003 12:00AM" ,
update-date
str "Dec 21 2003 7:01AM" } ,
{
type generif ,
text "In human, NAT2 polymorphism may be a genetic risk factor for joint
destruction." ,
version 0 ,
refs {
pmid 15005011 } ,
create-date
str "May 7 2004 12:00AM" ,
update-date
str "May 16 2004 7:01AM" } ,
{
type generif ,
text "It is unlikely that the NAT1*10 or NAT2 rapid/intermediate
genotypes are related to stomach cancer risk." ,
version 0 ,
refs {
pmid 12692115 } ,
create-date
str "Sep 4 2003 12:00AM" ,
update-date
str "Sep 28 2003 7:01AM" } ,
{
type generif ,
text "genetic polymorphisms of NAT1 and NAT2 have no independent effect
on breast cancer risk, but they modulate breast cancer risk in the presence
of GSTM1 and GSTT1 null genotypes." ,
version 0 ,
refs {
pmid 12860276 } ,
create-date
str "Aug 18 2003 12:00AM" ,
update-date
str "Aug 24 2003 7:01AM" } ,
{
type generif ,
text "NAT2 slow acetylator genotype plays an important role in
determining the risk of developing prostate cancer in Japanese men and is
also associated with more clinically advanced and pathologically aggressive
disease." ,
version 0 ,
refs {
pmid 12622714 } ,
create-date
str "Aug 9 2003 12:00AM" ,
update-date
str "Aug 24 2003 7:01AM" } ,
{
type generif ,
text "Polymorphism of Nat2 encoding phase 2 xenobiotic detoxication
enzyme was studied." ,
version 0 ,
refs {
pmid 12760253 } ,
create-date
str "Jun 26 2003 12:00AM" ,
update-date
str "Aug 10 2003 7:01AM" } ,
{
type generif ,
text "This enzyme is polymorphic in various ethnic populations of South
India." ,
version 0 ,
refs {
pmid 12469231 } ,
create-date
str "May 24 2003 12:00AM" ,
update-date
str "Jul 27 2003 7:01AM" } ,
{
type generif ,
text "Maternal NAT2 acetylator status seems not to be an important
factor in the etiology of orofacial clefts." ,
version 0 ,
refs {
pmid 12397635 } ,
create-date
str "May 7 2003 12:00AM" ,
update-date
str "Jun 1 2003 7:01AM" } ,
{
type generif ,
text "Genotyping the NAT2 gene and estimating diplotype configuration
before administration of SSZ may reduce the frequency of adverse effects in
Japanese patients with RA." ,
version 0 ,
refs {
pmid 12465141 } ,
create-date
str "May 2 2003 12:00AM" ,
update-date
str "May 11 2003 7:01AM" } ,
{
type generif ,
text "Single nucleotide polymorphisms of NAT1 and NAT2, and acetylation
haplotype were not associated with increased risk for Parkinson disease" ,
version 0 ,
refs {
pmid 12682333 } ,
create-date
str "Apr 11 2003 12:00AM" ,
update-date
str "Apr 27 2003 7:01AM" } ,
{
type generif ,
text "lack of association between polymorphism of this gene and systemic
lupus erythematosus" ,
version 0 ,
refs {
pmid 12360107 } ,
create-date
str "Apr 9 2003 12:00AM" ,
update-date
str "Apr 27 2003 7:01AM" } ,
{
type generif ,
text "Polymorphic N-acetyltransferase (NAT2) is involved in the
metabolism of several compounds relevant in pharmacology or toxicology, with
diverse clinical consequences--review" ,
version 0 ,
refs {
pmid 12611196 } ,
create-date
str "Mar 24 2003 12:00AM" ,
update-date
str "Mar 31 2003 6:30AM" } ,
{
type generif ,
text "N-acetyltransferase 2*19 possessing the C190T (R64W) single
nucleotide polymorphisms encodes a slow acetylator phenotype for both N- and
O-acetylation, due to a reduction in the amount and stability of the NAT2 19
allozyme" ,
version 0 ,
refs {
pmid 12222688 } ,
create-date
str "Mar 10 2003 12:00AM" ,
update-date
str "Apr 13 2003 7:01AM" } ,
{
type generif ,
text "NAT2 slow acetylation and GSTM1 null genotypes may increase
postmenopausal breast cancer risk in long-term smoking women." ,
version 0 ,
refs {
pmid 12835615 } ,
create-date
str "Mar 7 2004 12:00AM" ,
update-date
str "Apr 18 2004 7:02AM" } ,
{
type generif ,
text "A slow acetylator genotype of this enzyme is associated with an
increased risk of advanced cervical cancer." ,
version 0 ,
refs {
pmid 12474054 } ,
create-date
str "Feb 27 2003 12:00AM" ,
update-date
str "Apr 13 2003 7:01AM" } ,
{
type generif ,
text "Women with the GSTT1 null genotype were found to have a
significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8),
while GSTM1 and NAT2 genotypes were not associated with breast cancer risk." ,
version 0 ,
refs {
pmid 12430181 } ,
create-date
str "Nov 25 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:01AM" } ,
{
type generif ,
text "NAT2 slow genotype with NAT1 polymorphism indicates increased
susceptibility to prostate cancer" ,
version 0 ,
refs {
pmid 12355549 } ,
create-date
str "Oct 31 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:01AM" } ,
{
type generif ,
text "NAT2 slow acetylation genotype may be a risk factor of individual
susceptibility to rheumatoid arthritis." ,
version 0 ,
refs {
pmid 12235453 } ,
create-date
str "Oct 7 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:01AM" } ,
{
type generif ,
text "NAT2 acetylator status can influence susceptibility to breast
cancer after exposure to tobacco smoke carcinogens; effect appears to be
differential for active and passive smoke exposure" ,
version 0 ,
refs {
pmid 12163321 } ,
create-date
str "Sep 7 2002 12:00AM" ,
update-date
str "Sep 16 2002 5:48AM" } ,
{
type generif ,
text "NAT2 polymorphisms may be correlated with an increased risk of
larynx cancer" ,
version 0 ,
refs {
pmid 12037388 } ,
create-date
str "Aug 19 2002 12:00AM" ,
update-date
str "Aug 28 2002 6:15PM" } ,
{
type generif ,
text "The combined effect of N-acetyltransferase 2 (NAT2) slow genotype
and exposure to smoking is observed during the development of laryngeal
cancer." ,
version 0 ,
refs {
pmid 12015038 } ,
create-date
str "Aug 9 2002 12:00AM" ,
update-date
str "Sep 16 2002 5:48AM" } ,
{
type generif ,
text "urinary excretion of
N(2)-(beta-1-glucos-iduronyl)-2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]p
yridine relationship to activity levels of NAT2" ,
version 0 ,
refs {
pmid 12016157 } ,
create-date
str "Jun 12 2002 12:00AM" ,
update-date
str "Jun 24 2002 6:31AM" } ,
{
type generif ,
text "Polymorphism of the N-acetyltransferase 2 gene as a susceptibility
risk factor for antituberculosis drug-induced hepatitis." ,
version 0 ,
refs {
pmid 11915035 } ,
create-date
str "Apr 15 2002 12:00AM" ,
update-date
str "Apr 28 2002 6:17PM" } ,
{
type generif ,
text "Association between bone loss in periodontal disease and
polymorphism of N-acetyltransferase (NAT2)" ,
version 0 ,
refs {
pmid 11846845 } ,
create-date
str "Apr 9 2002 12:00AM" ,
update-date
str "May 14 2002 5:48AM" } ,
{
type generif ,
text "we investigated the relationship between the levels of aromatic
DNA adducts in breast tissues and polymorphisms of the drug-metabolizing
genes CYP1A1, NAT2, and GSTM1 in 166 women having breast cancer" ,
version 0 ,
refs {
pmid 11872636 } ,
create-date
str "Apr 2 2002 12:00AM" ,
update-date
str "Apr 8 2002 3:24PM" } } ,
unique-keys {
{
db "LocusID" ,
tag
id 10 } ,
{
db "MIM" ,
tag
id 243400 } } ,
xtra-index-terms {
"LOC10" } }
Entrezgene ::= {
track-info {
geneid 11 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 3 ,
day 5 ,
hour 11 ,
minute 30 ,
second 0 } } ,
type pseudo ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "8" } } } ,
gene {
locus "AACP" ,
desc "arylamide acetylase pseudogene" ,
maploc "8p22" ,
syn {
"NATP" } ,
locus-tag "HGNC:15" } ,
location {
{
display-str "8p22" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 11 ,
src-str2 "11" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "AACP" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "arylamide acetylase pseudogene" ,
version 0 } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "HGNC" ,
tag
id 15 } } } } ,
{
type comment ,
version 0 ,
refs {
pmid 2340091 } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "X17060" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 34995 } ,
anchor "X17060" } } ,
seqs {
whole
gi 34995 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GDB" ,
tag
str "GDB:132838" } } } } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11 } } ,
xtra-index-terms {
"LOC11" } }
Entrezgene ::= {
track-info {
geneid 12 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 14 ,
hour 13 ,
minute 15 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "14" } } } ,
gene {
locus "SERPINA3" ,
desc "serine (or cysteine) proteinase inhibitor, clade A (alpha-1
antiproteinase, antitrypsin), member 3" ,
maploc "14q32.1" ,
db {
{
db "MIM" ,
tag
id 107280 } } ,
syn {
"ACT" ,
"AACT" ,
"MGC88254" } ,
locus-tag "HGNC:16" } ,
prot {
name {
"serine (or cysteine) proteinase inhibitor, clade A, member 3" ,
"antichymotrypsin" ,
"alpha-1-antichymotrypsin" ,
"serine (or cysteine) proteinase inhibitor, clade A, member 3" } } ,
summary "The protein encoded by this gene is a plasma protease inhibitor and
member of the serine protease inhibitor class. Polymorphisms in this protein
appear to be tissue specific and influence protease targeting. Variation in
this protein's sequence have been implicated in Alzheimer's disease, and
deficiency of this protein has been associated with liver disease. Mutations
have been identified in patients with Parkinson disease and chronic
obstructive pulmonary disease." ,
location {
{
display-str "14q32.1" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 12 ,
src-str2 "12" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000014" ,
version 7 ,
seqs {
int {
from 94150523 ,
to 94160143 ,
strand plus ,
id
gi 51511730 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001085" ,
version 2 ,
genomic-coords {
mix {
int {
from 94150523 ,
to 94151173 ,
strand plus ,
id
gi 51511730 } ,
int {
from 94155284 ,
to 94155557 ,
strand plus ,
id
gi 51511730 } ,
int {
from 94158430 ,
to 94158580 ,
strand plus ,
id
gi 51511730 } ,
int {
from 94159700 ,
to 94160143 ,
strand plus ,
id
gi 51511730 } } } ,
seqs {
whole
gi 9665246 } ,
products {
{
type peptide ,
heading "Reference" ,
label "precursor" ,
accession "NP_001076" ,
version 1 ,
genomic-coords {
packed-int {
{
from 94150531 ,
to 94151173 ,
strand plus ,
id
gi 51511730 } ,
{
from 94155284 ,
to 94155557 ,
strand plus ,
id
gi 51511730 } ,
{
from 94158430 ,
to 94158580 ,
strand plus ,
id
gi 51511730 } ,
{
from 94159700 ,
to 94159935 ,
strand plus ,
id
gi 51511730 } } } ,
seqs {
whole
gi 4501843 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_026437" ,
version 11 ,
seqs {
int {
from 76080523 ,
to 76090143 ,
strand plus ,
id
gi 51493278 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001085" ,
version 2 ,
genomic-coords {
mix {
int {
from 76080523 ,
to 76081173 ,
strand plus ,
id
gi 51493278 } ,
int {
from 76085284 ,
to 76085557 ,
strand plus ,
id
gi 51493278 } ,
int {
from 76088430 ,
to 76088580 ,
strand plus ,
id
gi 51493278 } ,
int {
from 76089700 ,
to 76090143 ,
strand plus ,
id
gi 51493278 } } } ,
seqs {
whole
gi 9665246 } ,
products {
{
type peptide ,
heading "Reference" ,
label "precursor" ,
accession "NP_001076" ,
version 1 ,
genomic-coords {
packed-int {
{
from 76080531 ,
to 76081173 ,
strand plus ,
id
gi 51493278 } ,
{
from 76085284 ,
to 76085557 ,
strand plus ,
id
gi 51493278 } ,
{
from 76088430 ,
to 76088580 ,
strand plus ,
id
gi 51493278 } ,
{
from 76089700 ,
to 76089935 ,
strand plus ,
id
gi 51493278 } } } ,
seqs {
whole
gi 4501843 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_086807" ,
version 1 ,
seqs {
int {
from 23153523 ,
to 23163143 ,
strand plus ,
id
gi 51472322 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001085" ,
version 2 ,
genomic-coords {
mix {
int {
from 23153523 ,
to 23154173 ,
strand plus ,
id
gi 51472322 } ,
int {
from 23158284 ,
to 23158557 ,
strand plus ,
id
gi 51472322 } ,
int {
from 23161430 ,
to 23161580 ,
strand plus ,
id
gi 51472322 } ,
int {
from 23162700 ,
to 23163143 ,
strand plus ,
id
gi 51472322 } } } ,
seqs {
whole
gi 9665246 } ,
products {
{
type peptide ,
heading "Reference" ,
label "precursor" ,
accession "NP_001076" ,
version 1 ,
genomic-coords {
packed-int {
{
from 23153531 ,
to 23154173 ,
strand plus ,
id
gi 51472322 } ,
{
from 23158284 ,
to 23158557 ,
strand plus ,
id
gi 51472322 } ,
{
from 23161430 ,
to 23161580 ,
strand plus ,
id
gi 51472322 } ,
{
from 23162700 ,
to 23162935 ,
strand plus ,
id
gi 51472322 } } } ,
seqs {
whole
gi 4501843 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "SERPINA3" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "serine (or cysteine) proteinase inhibitor, clade A (alpha-1
antiproteinase, antitrypsin), member 3" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "GOA" ,
url "http://www.ebi.ac.uk/GOA/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 9880565 } ,
source {
{
src {
db "GO" ,
tag
id 3677 } ,
anchor "DNA binding" ,
post-text "evidence: IC" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 9880565 } ,
source {
{
src {
db "GO" ,
tag
id 30569 } ,
anchor "chymotrypsin inhibitor activity" ,
post-text "evidence: NAS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12709365 } ,
source {
{
src {
db "GO" ,
tag
id 5515 } ,
anchor "protein binding" ,
post-text "evidence: IPI" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 4867 } ,
anchor "serine-type endopeptidase inhibitor activity" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 6953 } ,
anchor "acute-phase response" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12475184 } ,
source {
{
src {
db "GO" ,
tag
id 6954 } ,
anchor "inflammatory response" ,
post-text "evidence: NAS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 11835318 } ,
source {
{
src {
db "GO" ,
tag
id 19216 } ,
anchor "regulation of lipid metabolism" ,
post-text "evidence: NAS" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 6810 } ,
anchor "transport" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 9880565 ,
pmid 14718574 } ,
source {
{
src {
db "GO" ,
tag
id 5576 } ,
anchor "extracellular region" ,
post-text "evidence: NAS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 9880565 } ,
source {
{
src {
db "GO" ,
tag
id 5622 } ,
anchor "intracellular" ,
post-text "evidence: NAS" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 5634 } ,
anchor "nucleus" ,
post-text "evidence: IEA" } } } } } } } } ,
homology {
{
type comment ,
heading "Mouse, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 40658 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=14&
MAPS=genes-r-org/rat-chr/human%3A14,genes-r-org/mouse-chr/human%3A14,genes-r-o
rg/human-chr14&query=e%3A12[id]+AND+gene[obj_type]&QSTR=serpina3&cmd=focus&fil
l=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "HGNC" ,
tag
id 16 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15546506 ,
pmid 15542006 ,
pmid 15530656 ,
pmid 15014966 ,
pmid 14718574 ,
pmid 14702039 ,
pmid 14668352 ,
pmid 12709365 ,
pmid 12600202 ,
pmid 12477932 ,
pmid 12475184 ,
pmid 12324297 ,
pmid 12023832 ,
pmid 11992569 ,
pmid 11959399 ,
pmid 11936240 ,
pmid 11835318 ,
pmid 11798857 ,
pmid 11735417 ,
pmid 11692021 ,
pmid 11317942 ,
pmid 11289720 ,
pmid 11274154 ,
pmid 11096092 ,
pmid 10829039 ,
pmid 10759471 ,
pmid 10660528 ,
pmid 10512690 ,
pmid 10228625 ,
pmid 10048303 ,
pmid 9880565 ,
pmid 9824262 ,
pmid 9698370 ,
pmid 9635374 ,
pmid 9580375 ,
pmid 9428387 ,
pmid 9261179 ,
pmid 9042371 ,
pmid 8849841 ,
pmid 8739078 ,
pmid 8732755 ,
pmid 8718849 ,
pmid 8376411 ,
pmid 8365378 ,
pmid 8267879 ,
pmid 8244391 ,
pmid 8226889 ,
pmid 8216224 ,
pmid 8011628 ,
pmid 7966721 ,
pmid 7924407 ,
pmid 7873202 ,
pmid 7759598 ,
pmid 7588564 ,
pmid 7528097 ,
pmid 6762318 ,
pmid 6687683 ,
pmid 6606438 ,
pmid 6556193 ,
pmid 6547997 ,
pmid 3637050 ,
pmid 3492865 ,
pmid 3490907 ,
pmid 3485824 ,
pmid 3260956 ,
pmid 3257719 ,
pmid 3028924 ,
pmid 2945424 ,
pmid 2456771 ,
pmid 2435303 ,
pmid 2432851 ,
pmid 2404007 ,
pmid 2190106 ,
pmid 1618300 ,
pmid 1351206 ,
pmid 1311327 } } ,
{
type comment ,
heading "Phenotypes" ,
version 0 ,
comment {
{
type phenotype ,
text "Alpha-1-antichymotrypsin deficiency" ,
version 0 ,
source {
{
src {
db "MIM" ,
tag
id 107280 } ,
anchor "MIM: 107280" } } } ,
{
type phenotype ,
text "Cerebrovascular disease, occlusive" ,
version 0 ,
source {
{
src {
db "MIM" ,
tag
id 107280 } ,
anchor "MIM: 107280" } } } } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 32177 } ,
anchor "RH1625" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "RH77711" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "stSG1393" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 37467 } ,
anchor "SHGC-32982" ,
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comment {
{
type other ,
label "Alternate name" ,
text "EST128561" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH32590" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH53830" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "SGC32982" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 64155 } ,
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post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "GDB:588356" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH53900" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "UTR-04554" ,
version 0 } ,
{
type other ,
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text "WI-7103" ,
version 0 } } } ,
{
type comment ,
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{
src {
db "UniSTS" ,
tag
id 66238 } ,
anchor "G31126" ,
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comment {
{
type other ,
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{
type comment ,
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source {
{
src {
db "UniSTS" ,
tag
id 74665 } ,
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comment {
{
type other ,
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version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 86678 } ,
anchor "RH91507" ,
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{
type other ,
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version 0 } } } ,
{
type comment ,
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{
src {
db "UniSTS" ,
tag
id 272387 } ,
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{
type comment ,
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{
type mRNA ,
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{
src {
db "Nucleotide" ,
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id 50659079 } ,
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gi 50659079 } ,
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id 50659080 } ,
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gi 50659080 } ,
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{
type other ,
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{
src {
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anchor "summary" } } ,
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src {
db "CDD" ,
tag
id 28234 } ,
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{
type other ,
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version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "BC003559,BG565041" } ,
anchor "BC003559,BG565041" } } ,
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type other ,
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{
type comment ,
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{
type genomic ,
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accession "X00947" ,
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source {
{
src {
db "Nucleotide" ,
tag
id 28331 } ,
anchor "X00947" } } ,
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gi 28331 } ,
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{
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{
src {
db "Protein" ,
tag
id 28332 } ,
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gi 28332 } } } } ,
{
type genomic ,
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{
src {
db "Nucleotide" ,
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id 439137 } ,
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gi 439137 } ,
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{
type peptide ,
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{
src {
db "Protein" ,
tag
id 1340142 } ,
anchor "CAA48671" } } ,
seqs {
whole
gi 1340142 } } } } ,
{
type mRNA ,
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accession "AB209060" ,
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{
src {
db "Nucleotide" ,
tag
id 62087699 } ,
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whole
gi 62087699 } ,
products {
{
type peptide ,
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source {
{
src {
db "Protein" ,
tag
id 62087700 } ,
anchor "BAD92297" } } ,
seqs {
whole
gi 62087700 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AF089747" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 4165889 } ,
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seqs {
whole
gi 4165889 } ,
products {
{
type peptide ,
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version 1 ,
source {
{
src {
db "Protein" ,
tag
id 4165890 } ,
anchor "AAD08810" } } ,
seqs {
whole
gi 4165890 } } } } ,
{
type mRNA ,
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accession "AK093049" ,
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source {
{
src {
db "Nucleotide" ,
tag
id 21751790 } ,
anchor "AK093049" } } ,
seqs {
whole
gi 21751790 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
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accession "AK096120" ,
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source {
{
src {
db "Nucleotide" ,
tag
id 21755531 } ,
anchor "AK096120" } } ,
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whole
gi 21755531 } ,
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{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
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accession "AK123091" ,
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source {
{
src {
db "Nucleotide" ,
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id 34528556 } ,
anchor "AK123091" } } ,
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gi 34528556 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
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{
src {
db "Nucleotide" ,
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id 13097704 } ,
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gi 13097704 } ,
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{
type peptide ,
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{
src {
db "Protein" ,
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id 13097705 } ,
anchor "AAH03559" } } ,
seqs {
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gi 13097705 } } } } ,
{
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{
src {
db "Nucleotide" ,
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id 14714765 } ,
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gi 14714765 } ,
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{
type peptide ,
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{
src {
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gi 14714766 } } } } ,
{
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id 15341984 } ,
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gi 15341984 } ,
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{
src {
db "Protein" ,
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id 15341985 } ,
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gi 15341985 } } } } ,
{
type mRNA ,
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{
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db "Nucleotide" ,
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gi 21961492 } ,
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{
type peptide ,
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{
src {
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gi 21961493 } } } } ,
{
type mRNA ,
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{
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gi 47124538 } } } } ,
{
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{
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gi 13572694 } ,
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{
type peptide ,
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{
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{
src {
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whole
gi 177932 } ,
products {
{
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source {
{
src {
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gi 177933 } } } } ,
{
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gi 177808 } ,
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{
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{
src {
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seqs {
whole
gi 177809 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "M18906" ,
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{
src {
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anchor "M18906" } } ,
seqs {
whole
gi 177928 } ,
products {
{
type peptide ,
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source {
{
src {
db "Protein" ,
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gi 177931 } } } } ,
{
type other ,
text "None" ,
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products {
{
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version 0 ,
source {
{
src {
db "Protein" ,
tag
id 112874 } ,
anchor "P01011" } } ,
seqs {
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gi 112874 } } } } } } ,
{
type comment ,
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comment {
{
type comment ,
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{
src {
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anchor "Evidence Viewer" ,
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{
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url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
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{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
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tag "UNIGENE" ,
value "Hs.534293" } } ,
source {
{
src {
db "UniGene" ,
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anchor "Hs.534293" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=53
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{
type comment ,
text "MIM" ,
version 0 ,
source {
{
src {
db "MIM" ,
tag
str "107280" } ,
anchor "107280" } } } ,
{
type comment ,
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source {
{
src {
db "HomoloGene" ,
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str "12" } ,
anchor "HomoloGene" ,
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{
type comment ,
version 0 ,
source {
{
src {
db "AceView" ,
tag
id 12 } ,
anchor "AceView" ,
url "http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
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{
type comment ,
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source {
{
src {
db "GDB" ,
tag
str "GDB:118955" } } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Homo_sapiens/contigview?geneid=AK093
049" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
AK093049" } } } ,
{
type comment ,
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source {
{
src {
db "KEGG" ,
tag
str "" } ,
url "http://www.genome.ad.jp/dbget-bin/www_bget?hsa:12" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC003559,BC010530,BC034554" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC003559
,BC010530,BC034554" } } } } } ,
{
type comment ,
heading "Pathways" ,
version 0 ,
comment {
{
type comment ,
text "KEGG pathway: Alzheimer's disease" ,
version 0 ,
source {
{
src {
db "05010" ,
tag
str "05010" } ,
anchor "05010" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa05010+12" } } } } } ,
{
type generif ,
text "overexpression of ACT by astrocytes could thus contribute to
increased beta-amyloid fibril formation in Alzheimer's disease" ,
version 0 ,
refs {
pmid 15530656 } ,
create-date
str "Jan 29 2005 10:01AM" ,
update-date
str "Jan 29 2005 1:54PM" } ,
{
type generif ,
text "Multivariate analysis showed that ACT mRNA level, but not STC2
mRNA level, in HR-positive patients, was a significant prognostic factor (P =
0.042), which was independent of tumor size and lymph node metastases." ,
version 0 ,
refs {
pmid 15546506 } ,
create-date
str "Jan 15 2005 10:01AM" ,
update-date
str "Jan 15 2005 4:35PM" } ,
{
type generif ,
text "Alpha1-antichymotrypsin-AA may confer a modest protection against
developing early-onset Parkinson disease in women" ,
version 0 ,
refs {
pmid 15542006 } ,
create-date
str "Jan 15 2005 10:01AM" ,
update-date
str "Jan 15 2005 1:01PM" } ,
{
type generif ,
text "Polymeric AACT specifically seeds the polymerization of native
protein by a serpin-dependent process that occurs under physiological
conditions and may be important in the deposition of AACT in plaques in
patients with Alzheimer's disease." ,
version 0 ,
refs {
pmid 12600202 } ,
create-date
str "May 26 2003 12:00AM" ,
update-date
str "Jun 1 2003 7:01AM" } ,
{
type generif ,
text "alpha(1)-antichymotrypsin polymorphism: a risk factor for
hemorrhagic stroke in normotensive subjects." ,
version 0 ,
refs {
pmid 11692021 } ,
create-date
str "Mar 5 2003 12:00AM" ,
update-date
str "Mar 23 2003 7:01AM" } ,
{
type generif ,
text "alpha(1)-antitrypsin and antichymotrypsin are produced by the
mammary gland and are present in milk in relatively high amounts in early
lactation" ,
version 0 ,
refs {
pmid 12324297 } ,
create-date
str "Oct 11 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:01AM" } ,
{
type generif ,
text "Gene regulation of the serine proteinase inhibitors
alpha1-antitrypsin and alpha1-antichymotrypsin." ,
version 0 ,
refs {
pmid 12023832 } ,
create-date
str "Oct 9 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:01AM" } ,
{
type generif ,
text "data suggested that the ApoE epsilon2/epsilon4 genotype might be a
susceptibility variant of moderate effect for sporadic idiopathic Parkinson
disease in our samples, whereas the ACT gene signal peptide polymorphism
might not" ,
version 0 ,
refs {
pmid 11992569 } ,
create-date
str "Sep 26 2002 12:00AM" ,
update-date
str "Oct 7 2002 8:10AM" } ,
{
type generif ,
text "no association seen between alpha 1-antichymotrypsin and time to
psychosis in Alzheimer's disease" ,
version 0 ,
refs {
pmid 11936240 } ,
create-date
str "Aug 28 2002 12:00AM" ,
update-date
str "Sep 16 2002 5:48AM" } ,
{
type generif ,
text "significantly higher in plasma of Alzheimer patients compared to
controls" ,
version 0 ,
refs {
pmid 11959399 } ,
create-date
str "Jul 22 2002 12:00AM" ,
update-date
str "Jul 29 2002 6:27PM" } ,
{
type generif ,
text "A25G and G39A substitutions in the AACT gene are probably one of
the risk factors to Alzheimer's disease (AD) in Han Chinese." ,
version 0 ,
refs {
pmid 11798857 } ,
create-date
str "Apr 7 2002 12:00AM" ,
update-date
str "Apr 13 2002 5:25PM" } ,
{
type generif ,
heading "Interactions" ,
version 0 ,
comment {
{
type generif ,
text "Alpha-1 ACT interacts with and inhibits cathepsin G." ,
version 0 ,
refs {
pmid 15131125 } ,
source {
{
src {
db "BIND" ,
tag
id 149291 } ,
anchor "BIND" } } ,
comment {
{
type comment ,
label "SERPINA3" ,
accession "NP_001076" ,
version 1 } ,
{
type comment ,
label "CTSG" ,
accession "NP_001902" ,
version 1 ,
source {
{
src {
db "GeneID" ,
tag
id 1511 } } } } } ,
create-date
str "2005-01-21 20:10 EDT" ,
update-date
str "2005-01-21 20:19 EDT" } ,
{
type generif ,
text "LRP interacts with alpha-1-ACT." ,
version 0 ,
refs {
pmid 15131125 } ,
source {
{
src {
db "BIND" ,
tag
id 149296 } ,
anchor "BIND" } } ,
comment {
{
type comment ,
label "SERPINA3" ,
accession "NP_001076" ,
version 1 } ,
{
type comment ,
label "LRP1" ,
accession "NP_002323" ,
version 1 ,
source {
{
src {
db "GeneID" ,
tag
id 4035 } } } } } ,
create-date
str "2005-01-21 20:10 EDT" ,
update-date
str "2005-01-21 20:19 EDT" } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 12 } ,
{
db "MIM" ,
tag
id 107280 } } ,
xtra-index-terms {
"LOC12" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype" } } }
Entrezgene ::= {
track-info {
geneid 13 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 3 ,
day 5 ,
hour 11 ,
minute 30 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "3" } } } ,
gene {
locus "AADAC" ,
desc "arylacetamide deacetylase (esterase)" ,
maploc "3q21.3-q25.2" ,
db {
{
db "MIM" ,
tag
id 600338 } } ,
syn {
"DAC" } ,
locus-tag "HGNC:17" } ,
prot {
name {
"arylacetamide deacetylase" } } ,
summary "Microsomal arylacetamide deacetylase competes against the activity
of cytosolic arylamine N-acetyltransferase, which catalyzes one of the
initial biotransformation pathways for arylamine and heterocyclic amine
carcinogens" ,
location {
{
display-str "3q21.3-q25.2" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 13 ,
src-str2 "13" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000003" ,
version 9 ,
seqs {
int {
from 153014563 ,
to 153028971 ,
strand plus ,
id
gi 51511463 } } ,
products {
{
type mRNA ,
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accession "NM_001086" ,
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mix {
int {
from 153014563 ,
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strand plus ,
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gi 51511463 } ,
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gi 51511463 } ,
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strand plus ,
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gi 51511463 } ,
int {
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strand plus ,
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gi 51511463 } } } ,
seqs {
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gi 4557226 } ,
products {
{
type peptide ,
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accession "NP_001077" ,
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genomic-coords {
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{
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gi 51511463 } ,
{
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{
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gi 51511463 } ,
{
from 153025148 ,
to 153025319 ,
strand plus ,
id
gi 51511463 } ,
{
from 153028061 ,
to 153028657 ,
strand plus ,
id
gi 51511463 } } } ,
seqs {
whole
gi 4557227 } ,
comment {
{
type property ,
label "EC" ,
text "3.1.1.-" ,
version 0 ,
xtra-properties {
{
tag "EC" ,
value "3.1.1.-" } } } } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_005612" ,
version 14 ,
seqs {
int {
from 58027019 ,
to 58041427 ,
strand plus ,
id
gi 37550867 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001086" ,
version 1 ,
genomic-coords {
mix {
int {
from 58027019 ,
to 58027241 ,
strand plus ,
id
gi 37550867 } ,
int {
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strand plus ,
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gi 37550867 } ,
int {
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strand plus ,
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gi 37550867 } ,
int {
from 58037604 ,
to 58037775 ,
strand plus ,
id
gi 37550867 } ,
int {
from 58040517 ,
to 58041427 ,
strand plus ,
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gi 37550867 } } } ,
seqs {
whole
gi 4557226 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_001077" ,
version 1 ,
genomic-coords {
packed-int {
{
from 58027104 ,
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strand plus ,
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gi 37550867 } ,
{
from 58030307 ,
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strand plus ,
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{
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{
from 58037604 ,
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strand plus ,
id
gi 37550867 } ,
{
from 58040517 ,
to 58041113 ,
strand plus ,
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gi 37550867 } } } ,
seqs {
whole
gi 4557227 } ,
comment {
{
type property ,
label "EC" ,
text "3.1.1.-" ,
version 0 ,
xtra-properties {
{
tag "EC" ,
value "3.1.1.-" } } } } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_086641" ,
version 1 ,
seqs {
int {
from 24339789 ,
to 24354221 ,
strand plus ,
id
gi 51464125 } } ,
products {
{
type mRNA ,
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from 24339789 ,
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int {
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strand plus ,
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gi 51464125 } ,
int {
from 24346094 ,
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strand plus ,
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gi 51464125 } ,
int {
from 24350369 ,
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strand plus ,
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gi 51464125 } ,
int {
from 24353311 ,
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gi 51464125 } } } ,
seqs {
whole
gi 4557226 } ,
products {
{
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gi 51464125 } ,
{
from 24353311 ,
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seqs {
whole
gi 4557227 } ,
comment {
{
type property ,
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xtra-properties {
{
tag "EC" ,
value "3.1.1.-" } } } } } } } } } } ,
properties {
{
type comment ,
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version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "AADAC" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "arylacetamide deacetylase (esterase)" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "GOA" ,
url "http://www.ebi.ac.uk/GOA/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 9665742 } ,
source {
{
src {
db "GO" ,
tag
id 19213 } ,
anchor "deacetylase activity" ,
post-text "evidence: IDA" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 8152 } ,
anchor "metabolism" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 10318829 ,
pmid 15152005 } ,
source {
{
src {
db "GO" ,
tag
id 5789 } ,
anchor "endoplasmic reticulum membrane" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16021 } ,
anchor "integral to membrane" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 8063807 } ,
source {
{
src {
db "GO" ,
tag
id 5792 } ,
anchor "microsome" ,
post-text "evidence: TAS" } } } } } } } } ,
homology {
{
type comment ,
heading "Mouse, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 37436 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=3&M
APS=genes-r-org/rat-chr/human%3A3,genes-r-org/mouse-chr/human%3A3,genes-r-org/
human-chr3&query=e%3A13[id]+AND+gene[obj_type]&QSTR=aadac&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
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source {
{
src {
db "HGNC" ,
tag
id 17 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15152005 ,
pmid 12721789 ,
pmid 12477932 ,
pmid 10318829 ,
pmid 9665742 ,
pmid 9299245 ,
pmid 8063807 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 13170 } ,
anchor "STS-L32179" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "RH41545" ,
version 0 } ,
{
type other ,
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text "sts-L32179" ,
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{
type comment ,
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src {
db "UniSTS" ,
tag
id 18863 } ,
anchor "D3S4189" ,
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comment {
{
type other ,
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text "SHGC-9733" ,
version 0 } } } ,
{
type comment ,
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{
src {
db "UniSTS" ,
tag
id 24707 } ,
anchor "RH36344" ,
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comment {
{
type other ,
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text "stSG13141" ,
version 0 } } } ,
{
type comment ,
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{
src {
db "UniSTS" ,
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comment {
{
type other ,
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text "SHGC-105511" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
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{
src {
db "Nucleotide" ,
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id 4557226 } ,
anchor "NM_001086" } } ,
seqs {
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gi 4557226 } ,
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{
type peptide ,
heading "Product" ,
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{
src {
db "Protein" ,
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id 4557227 } ,
anchor "NP_001077" ,
post-text "arylacetamide deacetylase" } } ,
seqs {
whole
gi 4557227 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 4557227 } ,
pre-text "(2)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 10527 } ,
anchor "COG0657: Aes; Esterase/lipase [Lipid
metabolism]" } } ,
comment {
{
type other ,
text "Location: 33 - 399 Blast Score: 380" ,
version 0 } } } ,
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 16555 } ,
anchor "cd00312: Esterase_lipase; Esterases and
lipases (includes fungal lipases, cholinesterases, etc" } } ,
comment {
{
type other ,
text "Location: 91 - 203 Blast Score: 144" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "L32179" } ,
anchor "L32179" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA" ,
accession "BC020706" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 18088402 } ,
anchor "BC020706" } } ,
seqs {
whole
gi 18088402 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC032309" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 21595550 } ,
anchor "BC032309" } } ,
seqs {
whole
gi 21595550 } ,
products {
{
type peptide ,
accession "AAH32309" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 21595551 } ,
anchor "AAH32309" } } ,
seqs {
whole
gi 21595551 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "L32179" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 537513 } ,
anchor "L32179" } } ,
seqs {
whole
gi 537513 } ,
products {
{
type peptide ,
accession "AAA35551" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 537514 } ,
anchor "AAA35551" } } ,
seqs {
whole
gi 537514 } } } } ,
{
type other ,
text "None" ,
version 0 ,
products {
{
type peptide ,
accession "P22760" ,
version 0 ,
source {
{
src {
db "Protein" ,
tag
id 57015294 } ,
anchor "P22760" } } ,
seqs {
whole
gi 57015294 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "13" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=9606&conti
g=NT_005612.14&gene=AADAC&lid=13&from=58027020&to=58041428" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "13" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=96
06&contig=NT_005612.14&gene=AADAC&lid=13" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Hs.506908" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Hs.506908" } ,
anchor "Hs.506908" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=50
6908" } } } ,
{
type comment ,
text "MIM" ,
version 0 ,
source {
{
src {
db "MIM" ,
tag
str "600338" } ,
anchor "600338" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "13" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
13[loc]&TAXID=9606" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "AceView" ,
tag
id 13 } ,
anchor "AceView" ,
url "http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
ocusid&org=9606&l=13" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GDB" ,
tag
str "GDB:392587" } } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Homo_sapiens/contigview?geneid=BC032
309" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
BC032309" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "KEGG" ,
tag
str "" } ,
url "http://www.genome.ad.jp/dbget-bin/www_bget?hsa:13" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC032309" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC032309" } } } } } ,
{
type comment ,
heading "Pathways" ,
version 0 ,
comment {
{
type comment ,
text "KEGG pathway: Butanoate metabolism" ,
version 0 ,
source {
{
src {
db "00650" ,
tag
str "00650" } ,
anchor "00650" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa00650+13" } } } ,
{
type comment ,
text "KEGG pathway: Alkaloid biosynthesis II" ,
version 0 ,
source {
{
src {
db "00960" ,
tag
str "00960" } ,
anchor "00960" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa00960+13" } } } ,
{
type comment ,
text "KEGG pathway: 2,4-Dichlorobenzoate degradation" ,
version 0 ,
source {
{
src {
db "00623" ,
tag
str "00623" } ,
anchor "00623" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa00623+13" } } } ,
{
type comment ,
text "KEGG pathway: Pentose and glucuronate interconversions" ,
version 0 ,
source {
{
src {
db "00040" ,
tag
str "00040" } ,
anchor "00040" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa00040+13" } } } ,
{
type comment ,
text "KEGG pathway: Glycosylphosphatidylinositol(GPI)-anchor
biosynthesis" ,
version 0 ,
source {
{
src {
db "00563" ,
tag
str "00563" } ,
anchor "00563" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa00563+13" } } } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 13 } ,
{
db "MIM" ,
tag
id 600338 } } ,
xtra-index-terms {
"LOC13" } }
Entrezgene ::= {
track-info {
geneid 14 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 14 ,
hour 13 ,
minute 15 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
subtype {
{
subtype chromosome ,
name "2" } } } ,
gene {
locus "AAMP" ,
desc "angio-associated, migratory cell protein" ,
maploc "2q35" ,
db {
{
db "MIM" ,
tag
id 603488 } } ,
locus-tag "HGNC:18" } ,
prot {
name {
"angio-associated, migratory cell protein" } } ,
summary "The gene product is an immunoglobulin-type protein. It is found to
be expressed strongly in endothelial cells, cytotrophoblasts, and poorly
differentiated colon adenocarcinoma cells found in lymphatics. The protein
contains a heparin-binding domain and mediates heparin-sensitive cell
adhesion." ,
location {
{
display-str "2q35" ,
method
map-type cyto } } ,
gene-source {
src "LocusLink" ,
src-int 14 ,
src-str2 "14" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000002" ,
version 9 ,
seqs {
int {
from 218954357 ,
to 218960364 ,
strand minus ,
id
gi 51511462 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001087" ,
version 1 ,
genomic-coords {
mix {
int {
from 218954357 ,
to 218954835 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218955247 ,
to 218955401 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218955598 ,
to 218955688 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218955806 ,
to 218955909 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218956058 ,
to 218956173 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218956291 ,
to 218956374 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218956670 ,
to 218956814 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218957074 ,
to 218957213 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218957721 ,
to 218957840 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218959609 ,
to 218959761 ,
strand minus ,
id
gi 51511462 } ,
int {
from 218960193 ,
to 218960364 ,
strand minus ,
id
gi 51511462 } } } ,
seqs {
whole
gi 4557228 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_001078" ,
version 1 ,
genomic-coords {
packed-int {
{
from 218954760 ,
to 218954835 ,
strand minus ,
id
gi 51511462 } ,
{
from 218955247 ,
to 218955401 ,
strand minus ,
id
gi 51511462 } ,
{
from 218955598 ,
to 218955688 ,
strand minus ,
id
gi 51511462 } ,
{
from 218955806 ,
to 218955909 ,
strand minus ,
id
gi 51511462 } ,
{
from 218956058 ,
to 218956173 ,
strand minus ,
id
gi 51511462 } ,
{
from 218956291 ,
to 218956374 ,
strand minus ,
id
gi 51511462 } ,
{
from 218956670 ,
to 218956814 ,
strand minus ,
id
gi 51511462 } ,
{
from 218957074 ,
to 218957213 ,
strand minus ,
id
gi 51511462 } ,
{
from 218957721 ,
to 218957840 ,
strand minus ,
id
gi 51511462 } ,
{
from 218959609 ,
to 218959761 ,
strand minus ,
id
gi 51511462 } ,
{
from 218960193 ,
to 218960364 ,
strand minus ,
id
gi 51511462 } } } ,
seqs {
whole
gi 4557229 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_005403" ,
version 15 ,
seqs {
int {
from 69338267 ,
to 69344274 ,
strand minus ,
id
gi 51461028 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001087" ,
version 1 ,
genomic-coords {
mix {
int {
from 69338267 ,
to 69338745 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69339157 ,
to 69339311 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69339508 ,
to 69339598 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69339716 ,
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strand minus ,
id
gi 51461028 } ,
int {
from 69339968 ,
to 69340083 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69340201 ,
to 69340284 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69340580 ,
to 69340724 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69340984 ,
to 69341123 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69341631 ,
to 69341750 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69343519 ,
to 69343671 ,
strand minus ,
id
gi 51461028 } ,
int {
from 69344103 ,
to 69344274 ,
strand minus ,
id
gi 51461028 } } } ,
seqs {
whole
gi 4557228 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_001078" ,
version 1 ,
genomic-coords {
packed-int {
{
from 69338670 ,
to 69338745 ,
strand minus ,
id
gi 51461028 } ,
{
from 69339157 ,
to 69339311 ,
strand minus ,
id
gi 51461028 } ,
{
from 69339508 ,
to 69339598 ,
strand minus ,
id
gi 51461028 } ,
{
from 69339716 ,
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strand minus ,
id
gi 51461028 } ,
{
from 69339968 ,
to 69340083 ,
strand minus ,
id
gi 51461028 } ,
{
from 69340201 ,
to 69340284 ,
strand minus ,
id
gi 51461028 } ,
{
from 69340580 ,
to 69340724 ,
strand minus ,
id
gi 51461028 } ,
{
from 69340984 ,
to 69341123 ,
strand minus ,
id
gi 51461028 } ,
{
from 69341631 ,
to 69341750 ,
strand minus ,
id
gi 51461028 } ,
{
from 69343519 ,
to 69343671 ,
strand minus ,
id
gi 51461028 } ,
{
from 69344103 ,
to 69344274 ,
strand minus ,
id
gi 51461028 } } } ,
seqs {
whole
gi 4557229 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_086634" ,
version 1 ,
seqs {
int {
from 23772483 ,
to 23778490 ,
strand minus ,
id
gi 51463854 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_001087" ,
version 1 ,
genomic-coords {
mix {
int {
from 23772483 ,
to 23772961 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23773373 ,
to 23773527 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23773724 ,
to 23773814 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23773932 ,
to 23774035 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23774184 ,
to 23774299 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23774417 ,
to 23774500 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23774796 ,
to 23774940 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23775200 ,
to 23775339 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23775847 ,
to 23775966 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23777735 ,
to 23777887 ,
strand minus ,
id
gi 51463854 } ,
int {
from 23778319 ,
to 23778490 ,
strand minus ,
id
gi 51463854 } } } ,
seqs {
whole
gi 4557228 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_001078" ,
version 1 ,
genomic-coords {
packed-int {
{
from 23772886 ,
to 23772961 ,
strand minus ,
id
gi 51463854 } ,
{
from 23773373 ,
to 23773527 ,
strand minus ,
id
gi 51463854 } ,
{
from 23773724 ,
to 23773814 ,
strand minus ,
id
gi 51463854 } ,
{
from 23773932 ,
to 23774035 ,
strand minus ,
id
gi 51463854 } ,
{
from 23774184 ,
to 23774299 ,
strand minus ,
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gi 51463854 } ,
{
from 23774417 ,
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strand minus ,
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gi 51463854 } ,
{
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to 23774940 ,
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gi 51463854 } ,
{
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gi 51463854 } ,
{
from 23775847 ,
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strand minus ,
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gi 51463854 } ,
{
from 23777735 ,
to 23777887 ,
strand minus ,
id
gi 51463854 } ,
{
from 23778319 ,
to 23778490 ,
strand minus ,
id
gi 51463854 } } } ,
seqs {
whole
gi 4557229 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "HUGO Gene Nomenclature Committee" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "AAMP" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "angio-associated, migratory cell protein" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "GOA" ,
url "http://www.ebi.ac.uk/GOA/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 7743515 } ,
source {
{
src {
db "GO" ,
tag
id 8201 } ,
anchor "heparin binding" ,
post-text "evidence: TAS" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 6928 } ,
anchor "cell motility" ,
post-text "evidence: NR" } } } } } } } } ,
homology {
{
type comment ,
heading "Mouse, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 846 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&chr=2&M
APS=genes-r-org/rat-chr/human%3A2,genes-r-org/mouse-chr/human%3A2,genes-r-org/
human-chr2&query=e%3A14[id]+AND+gene[obj_type]&QSTR=aamp&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "HGNC" ,
tag
id 18 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 12477932 ,
pmid 11969303 ,
pmid 10329261 ,
pmid 8660919 ,
pmid 7743515 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 52581 } ,
anchor "SGC31591" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "CM4.18" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "GC" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "RH23156" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "STS4-18" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_001087" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 55743074 } ,
anchor "NM_001087" } } ,
seqs {
whole
gi 55743074 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_001078" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 55743075 } ,
anchor "NP_001078" ,
post-text "angio-associated, migratory cell protein" } } ,
seqs {
whole
gi 55743075 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 55743075 } ,
pre-text "(2)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5398 } ,
anchor "cd00200: WD40; WD40 domain, found in a
number of eukaryotic proteins that cover a wide variety of functions
including adaptor/regulatory modules in signal transduction, pre-mRNA
processing and cytoskeleton assembly" } } ,
comment {
{
type other ,
text "Location: 86 - 386 Blast Score: 457" ,
version 0 } ,
{
type other ,
text "Location: 325 - 430 Blast Score: 176" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "BG534787,CN277005,M95627" } ,
anchor "BG534787,CN277005,M95627" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA" ,
accession "AB209790" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 62089165 } ,
anchor "AB209790" } } ,
seqs {
whole
gi 62089165 } ,
products {
{
type peptide ,
accession "BAD93027" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 62089166 } ,
anchor "BAD93027" } } ,
seqs {
whole
gi 62089166 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK131047" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 34528300 } ,
anchor "AK131047" } } ,
seqs {
whole
gi 34528300 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC008809" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 39644831 } ,
anchor "BC008809" } } ,
seqs {
whole
gi 39644831 } ,
products {
{
type peptide ,
accession "AAH08809" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
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{
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seqs {
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{
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gi 48145626 } ,
products {
{
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seqs {
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{
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{
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products {
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{
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{
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source {
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{
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{
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source {
{
src {
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{
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{
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{
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tag
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Entrezgene ::= {
track-info {
geneid 15 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 20 ,
minute 30 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 14 ,
hour 13 ,
minute 15 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Homo sapiens" ,
common "human" ,
db {
{
db "taxon" ,
tag
id 9606 } } ,
syn {
"man" } ,
orgname {
name
binomial {
genus "Homo" ,
species "sapiens" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini;
Hominidae; Homo" ,
gcode 1 ,
mgcode 2 ,
div "PRI" } } ,
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{
subtype chromosome ,
name "17" } } } ,
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db {
{
db "MIM" ,
tag
id 600950 } } ,
syn {
"SNAT" ,
"AA-NAT" } ,
locus-tag "HGNC:19" } ,
prot {
name {
"arylalkylamine N-acetyltransferase" ,
"serotonin N-acetyltransferase" } } ,
summary "Arylalkylamine N-acetyltransferase belongs to the superfamily of
acetyltransferases. It is the penultimate enzyme in melatonin synthesis and
controls the night/day rhythm in melatonin production in the vertebrate
pineal gland. Melatonin is essential for seasonal reproduction, modulates the
function of the circadian clock in the suprachiasmatic nucleus, and
influences activity and sleep. This enzyme is rapidly inactivated when
animals are exposed to light at night. This protein is 80% identical to sheep
and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a
multifactorial genetic diseases such as altered behavior in sleep/wake cycle." ,
location {
{
display-str "17q25" ,
method
map-type cyto } } ,
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src "LocusLink" ,
src-int 15 ,
src-str2 "15" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
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{
type genomic ,
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version 9 ,
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int {
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products {
{
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gi 4501844 } ,
products {
{
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comment {
{
type property ,
label "EC" ,
text "2.3.1.87" ,
version 0 ,
xtra-properties {
{
tag "EC" ,
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{
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products {
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products {
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{
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properties {
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source {
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properties {
{
type property ,
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version 0 } ,
{
type property ,
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{
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{
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{
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src {
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{
type comment ,
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label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15332344 ,
pmid 12736803 ,
pmid 12552951 ,
pmid 12477932 ,
pmid 12039872 ,
pmid 11934439 ,
pmid 11427721 ,
pmid 11336675 ,
pmid 11313340 ,
pmid 9238858 ,
pmid 8661026 ,
pmid 7502081 ,
pmid 2181999 } } ,
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type mRNA ,
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{
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gi 4501844 } ,
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{
type peptide ,
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{
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db "Protein" ,
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comment {
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type other ,
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source {
{
src {
db "CCDS" ,
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{
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comment {
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comment {
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type other ,
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anchor "HomoloGene" ,
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15[loc]&TAXID=9606" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "AceView" ,
tag
id 15 } ,
anchor "AceView" ,
url "http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=l
ocusid&org=9606&l=15" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GDB" ,
tag
str "GDB:700076" } } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Homo_sapiens/contigview?geneid=U4034
7" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=
U40347" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "KEGG" ,
tag
str "" } ,
url "http://www.genome.ad.jp/dbget-bin/www_bget?hsa:15" } } } ,
{
type comment ,
text "PharmGKB" ,
version 0 ,
source {
{
src {
db "PharmGKB" ,
tag
str "PA24366" } ,
anchor "PA24366" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC069434" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Hs&LIST=BC069434" } } } } } ,
{
type comment ,
heading "Pathways" ,
version 0 ,
comment {
{
type comment ,
text "KEGG pathway: Tryptophan metabolism" ,
version 0 ,
source {
{
src {
db "00380" ,
tag
str "00380" } ,
anchor "00380" ,
url "http://www.genome.jp/dbget-bin/show_pathway?hsa00380+15" } } } } } ,
{
type generif ,
text "Data suggest that the -263G/C single nucleotide polymorphism of
arylalkylamine-N-acetyl-transferase (AA-NAT) may be an important determinant
of the late/short sleep pattern." ,
version 0 ,
refs {
pmid 15332344 } ,
create-date
str "Sep 27 2004 4:34PM" ,
update-date
str "Sep 27 2004 7:00PM" } ,
{
type generif ,
text "There is a significant increase in AANAT allele positivity at the
single nucleotide polymorphism (alanine 129--> threonine) at between patients
with DSPS & controls. AA-NAT could be a susceptibility gene for DSPS." ,
version 0 ,
refs {
pmid 12736803 } ,
create-date
str "Jul 10 2003 12:00AM" ,
update-date
str "May 30 2004 7:11AM" } } ,
unique-keys {
{
db "LocusID" ,
tag
id 15 } ,
{
db "MIM" ,
tag
id 600950 } } ,
xtra-index-terms {
"LOC15" } }
Entrezgene ::= {
track-info {
geneid 9996 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 320632 } ,
{
db "GeneID" ,
tag
id 320632 } } ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
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"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
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Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 9996 ,
src-str2 "9996" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 9996 } } ,
xtra-index-terms {
"LOC320632" } }
Entrezgene ::= {
track-info {
geneid 11286 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 50518 } ,
{
db "GeneID" ,
tag
id 50518 } } ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type unknown ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11286 ,
src-str2 "11286" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
properties {
{
type property ,
label "Property" ,
text "phenotype only" ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11286 } } ,
xtra-index-terms {
"LOC50518" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype only" } } }
Entrezgene ::= {
track-info {
geneid 11287 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 19 ,
hour 12 ,
minute 12 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } ,
subtype {
{
subtype chromosome ,
name "6" } } } ,
gene {
locus "Pzp" ,
desc "pregnancy zone protein" ,
maploc "6 62.0 cM" ,
syn {
"A1m" ,
"A2m" ,
"MAM" } ,
locus-tag "MGI:87854" } ,
prot {
name {
"pregnancy zone protein" ,
"alpha 1 macroglobulin" } } ,
location {
{
display-str "6 F1-G3" ,
method
map-type cyto } ,
{
display-str "6 62.0 cM" ,
method
map-type cM } } ,
gene-source {
src "LocusLink" ,
src-int 11287 ,
src-str2 "11287" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000072" ,
version 1 ,
seqs {
int {
from 129138521 ,
to 129181660 ,
strand minus ,
id
gi 51863714 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_007376" ,
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genomic-coords {
mix {
int {
from 129138521 ,
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strand minus ,
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gi 51863714 } ,
int {
from 129139811 ,
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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gi 51863714 } ,
int {
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int {
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int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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gi 51863714 } ,
int {
from 129149655 ,
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strand minus ,
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gi 51863714 } ,
int {
from 129150140 ,
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strand minus ,
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gi 51863714 } ,
int {
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to 129151075 ,
strand minus ,
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gi 51863714 } ,
int {
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to 129151700 ,
strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
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to 129161825 ,
strand minus ,
id
gi 51863714 } ,
int {
from 129165292 ,
to 129165355 ,
strand minus ,
id
gi 51863714 } ,
int {
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to 129167330 ,
strand minus ,
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gi 51863714 } ,
int {
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to 129168844 ,
strand minus ,
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gi 51863714 } ,
int {
from 129171020 ,
to 129171129 ,
strand minus ,
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gi 51863714 } ,
int {
from 129171763 ,
to 129171877 ,
strand minus ,
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gi 51863714 } ,
int {
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to 129174462 ,
strand minus ,
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gi 51863714 } ,
int {
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to 129176132 ,
strand minus ,
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gi 51863714 } ,
int {
from 129176963 ,
to 129177131 ,
strand minus ,
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gi 51863714 } ,
int {
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strand minus ,
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gi 51863714 } ,
int {
from 129178724 ,
to 129178776 ,
strand minus ,
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gi 51863714 } ,
int {
from 129178917 ,
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strand minus ,
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gi 51863714 } ,
int {
from 129180062 ,
to 129180245 ,
strand minus ,
id
gi 51863714 } ,
int {
from 129181526 ,
to 129181660 ,
strand minus ,
id
gi 51863714 } } } ,
seqs {
whole
gi 6680607 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_031402" ,
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genomic-coords {
packed-int {
{
from 129138651 ,
to 129138673 ,
strand minus ,
id
gi 51863714 } ,
{
from 129139811 ,
to 129139852 ,
strand minus ,
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
from 129142828 ,
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
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from 129146443 ,
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
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gi 51863714 } ,
{
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gi 51863714 } ,
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
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gi 51863714 } ,
{
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gi 51863714 } ,
{
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gi 51863714 } ,
{
from 129167103 ,
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gi 51863714 } ,
{
from 129168683 ,
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gi 51863714 } ,
{
from 129171020 ,
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gi 51863714 } ,
{
from 129171763 ,
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gi 51863714 } ,
{
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gi 51863714 } ,
{
from 129176048 ,
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gi 51863714 } ,
{
from 129176963 ,
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gi 51863714 } ,
{
from 129177687 ,
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gi 51863714 } ,
{
from 129178724 ,
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gi 51863714 } ,
{
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to 129179070 ,
strand minus ,
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gi 51863714 } ,
{
from 129180062 ,
to 129180245 ,
strand minus ,
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gi 51863714 } ,
{
from 129181526 ,
to 129181611 ,
strand minus ,
id
gi 51863714 } } } ,
seqs {
whole
gi 6680608 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_039356" ,
version 3 ,
seqs {
int {
from 3999237 ,
to 4042376 ,
strand minus ,
id
gi 51712708 } } ,
products {
{
type mRNA ,
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genomic-coords {
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
int {
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strand minus ,
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gi 51712708 } ,
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gi 51712708 } ,
int {
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
int {
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gi 51712708 } ,
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gi 51712708 } ,
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gi 51712708 } ,
int {
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gi 51712708 } ,
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strand minus ,
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gi 51712708 } } } ,
seqs {
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gi 6680607 } ,
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{
type peptide ,
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gi 51712708 } ,
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seqs {
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gi 6680608 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "Mouse Genome Informatics" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "Pzp" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "pregnancy zone protein" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "MGI" ,
url "http://www.informatics.jax.org/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 5559967 } ,
source {
{
src {
db "GO" ,
tag
id 4866 } ,
anchor "endopeptidase inhibitor activity" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 4867 } ,
anchor "serine-type endopeptidase inhibitor activity" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 17114 } ,
anchor "wide-spectrum protease inhibitor activity" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 5559967 } ,
source {
{
src {
db "GO" ,
tag
id 5576 } ,
anchor "extracellular region" ,
post-text "evidence: TAS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 5615 } ,
anchor "extracellular space" ,
post-text "evidence: TAS" } } } } } } } } ,
homology {
{
type comment ,
heading "Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 56378 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=6&
MAPS=genes-r-org/rat-chr/mouse%3A6,genes-r-org/mouse-chr6&query=e%3A11287[id]+
AND+gene[obj_type]&QSTR=pzp&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 87854 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "PROVISIONAL" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 12477932 ,
pmid 12466851 ,
pmid 7528166 ,
pmid 5559967 ,
pmid 1280217 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 140992 } ,
anchor "A2m" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "D6Uwa7" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "MGI:893149" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "Pzp" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 179416 } ,
anchor "AI838740" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "659717" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 179477 } ,
anchor "AI893533" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "681710" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_007376" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 6680607 } ,
anchor "NM_007376" } } ,
seqs {
whole
gi 6680607 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_031402" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 6680608 } ,
anchor "NP_031402" ,
post-text "pregnancy zone protein" } } ,
seqs {
whole
gi 6680608 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 6680608 } ,
pre-text "(2)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5952 } ,
anchor "pfam00207: A2M; Alpha-2-macroglobulin family" } } ,
comment {
{
type other ,
text "Location: 738 - 1482 Blast Score: 1820" ,
version 0 } } } ,
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 25832 } ,
anchor "pfam01835: A2M_N; Alpha-2-macroglobulin
family N-terminal region" } } ,
comment {
{
type other ,
text "Location: 22 - 622 Blast Score: 1231" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "M93264" } ,
anchor "M93264" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "U06977" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 463883 } ,
anchor "U06977" } } ,
seqs {
whole
gi 463883 } ,
products {
{
type peptide ,
accession "AAA87890" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 463884 } ,
anchor "AAA87890" } } ,
seqs {
whole
gi 463884 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC057983" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 34785995 } ,
anchor "BC057983" } } ,
seqs {
whole
gi 34785995 } ,
products {
{
type peptide ,
accession "AAH57983" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 34785996 } ,
anchor "AAH57983" } } ,
seqs {
whole
gi 34785996 } } } ,
comment {
{
type other ,
label "Strain" ,
text "FVB/N" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "M93264" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 199085 } ,
anchor "M93264" } } ,
seqs {
whole
gi 199085 } ,
products {
{
type peptide ,
accession "AAA39508" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 199086 } ,
anchor "AAA39508" } } ,
seqs {
whole
gi 199086 } } } } ,
{
type other ,
text "None" ,
version 0 ,
products {
{
type peptide ,
accession "Q61838" ,
version 0 ,
source {
{
src {
db "Protein" ,
tag
id 2492496 } ,
anchor "Q61838" } } ,
seqs {
whole
gi 2492496 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "11287" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
ig=NT_039356.3&gene=Pzp&lid=11287&from=3999238&to=4042377" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "11287" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
090&contig=NT_039356.3&gene=Pzp&lid=11287" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Mm.260144" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Mm.260144" } ,
anchor "Mm.260144" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=26
0144" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "11287" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
11287[loc]&TAXID=10090" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 87854 } ,
anchor "MGI" ,
url "http://www.informatics.jax.org/searches/accession_report.cg
i?id=MGI:87854" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Mus_musculus/contigview?geneid=BC057
983" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
BC057983" } } } ,
{
type comment ,
text "Gene Expression Database (GXD) at MGI" ,
version 0 ,
source {
{
src {
db "Gene Expression Database (GXD) at MGI" ,
tag
str "MGI:87854" } ,
anchor "MGI:87854" ,
url "http://www.informatics.jax.org/searches/expression_report.c
gi?id=MGI:87854" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC057983" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Mm&LIST=BC057983" } } } } } ,
{
type comment ,
heading "Alleles" ,
version 0 ,
comment {
{
type comment ,
text "The following allele types are documented at Mouse Genome
Informatics" ,
version 0 ,
source {
{
anchor "(MGI)" ,
url "http://www.informatics.jax.org/searches/allele_report.cgi?m
arkerID=MGI:87854" } } } ,
{
type comment ,
heading "Targeted (knock-out) (1)" ,
version 0 ,
refs {
pmid 7544347 } } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11287 } ,
{
db "MGI" ,
tag
id 87854 } } ,
xtra-index-terms {
"LOC11287" } }
Entrezgene ::= {
track-info {
geneid 11288 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 112131 } ,
{
db "GeneID" ,
tag
id 112131 } } ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type unknown ,
source {
genome genomic ,
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org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
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Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11288 ,
src-str2 "11288" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
properties {
{
type property ,
label "Property" ,
text "phenotype only" ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11288 } } ,
xtra-index-terms {
"LOC112131" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype only" } } }
Entrezgene ::= {
track-info {
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status secondary ,
current-id {
{
db "LocusID" ,
tag
id 107417 } ,
{
db "GeneID" ,
tag
id 107417 } } ,
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std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
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update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
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type protein-coding ,
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genome genomic ,
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taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
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Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
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gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11289 ,
src-str2 "11289" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11289 } } ,
xtra-index-terms {
"LOC107417" } }
Entrezgene ::= {
track-info {
geneid 11293 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 112132 } ,
{
db "GeneID" ,
tag
id 112132 } } ,
create-date
std {
year 2003 ,
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day 28 ,
hour 21 ,
minute 39 ,
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update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
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genome genomic ,
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org {
taxname "Mus musculus" ,
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db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
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gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11293 ,
src-str2 "11293" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
properties {
{
type property ,
label "Property" ,
text "phenotype only" ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11293 } } ,
xtra-index-terms {
"LOC112132" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype only" } } }
Entrezgene ::= {
track-info {
geneid 11294 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 109413 } ,
{
db "GeneID" ,
tag
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create-date
std {
year 2003 ,
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minute 39 ,
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update-date
std {
year 2005 ,
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day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type unknown ,
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genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
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gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11294 ,
src-str2 "11294" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
properties {
{
type property ,
label "Property" ,
text "phenotype only" ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11294 } } ,
xtra-index-terms {
"LOC109413" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype only" } } }
Entrezgene ::= {
track-info {
geneid 11295 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 109414 } ,
{
db "GeneID" ,
tag
id 109414 } } ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type unknown ,
source {
genome genomic ,
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org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
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gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11295 ,
src-str2 "11295" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
properties {
{
type property ,
label "Property" ,
text "phenotype only" ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11295 } } ,
xtra-index-terms {
"LOC109414" } ,
xtra-properties {
{
tag "PROP" ,
value "phenotype only" } } }
Entrezgene ::= {
track-info {
geneid 11296 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 104236 } ,
{
db "GeneID" ,
tag
id 104236 } } ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
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update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
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Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11296 ,
src-str2 "11296" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11296 } } ,
xtra-index-terms {
"LOC104236" } }
Entrezgene ::= {
track-info {
geneid 11297 ,
status secondary ,
current-id {
{
db "LocusID" ,
tag
id 227290 } ,
{
db "GeneID" ,
tag
id 227290 } } ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } } ,
gene {
} ,
gene-source {
src "LocusLink" ,
src-int 11297 ,
src-str2 "11297" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11297 } } ,
xtra-index-terms {
"LOC227290" } }
Entrezgene ::= {
track-info {
geneid 11298 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 3 ,
day 16 ,
hour 16 ,
minute 48 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
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gcode 1 ,
mgcode 2 ,
div "ROD" } } ,
subtype {
{
subtype chromosome ,
name "11" } } } ,
gene {
locus "Aanat" ,
desc "arylalkylamine N-acetyltransferase" ,
maploc "11 70.0 cM" ,
syn {
"Nat4" ,
"SNAT" ,
"Nat-2" } ,
locus-tag "MGI:1328365" } ,
prot {
name {
"arylalkylamine N-acetyltransferase" } } ,
location {
{
display-str "11 E2" ,
method
map-type cyto } ,
{
display-str "11 70.0 cM" ,
method
map-type cM } } ,
gene-source {
src "LocusLink" ,
src-int 11298 ,
src-str2 "11298" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000077" ,
version 1 ,
seqs {
int {
from 116264815 ,
to 116268672 ,
strand plus ,
id
gi 51868608 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_009591" ,
version 1 ,
genomic-coords {
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int {
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strand minus ,
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seqs {
whole
gi 6680609 } ,
products {
{
type peptide ,
heading "Reference" ,
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seqs {
whole
gi 6680610 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "Mouse Genome Informatics" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "Aatk" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "apoptosis-associated tyrosine kinase" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "MGI" ,
url "http://www.informatics.jax.org/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 5524 } ,
anchor "ATP binding" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16301 } ,
anchor "kinase activity" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 4672 } ,
anchor "protein kinase activity" ,
post-text "evidence: ISS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 4674 } ,
anchor "protein serine/threonine kinase activity" ,
post-text "evidence: ISS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 9444961 } ,
source {
{
src {
db "GO" ,
tag
id 4713 } ,
anchor "protein-tyrosine kinase activity" ,
post-text "evidence: ISS" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16740 } ,
anchor "transferase activity" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 9444961 } ,
source {
{
src {
db "GO" ,
tag
id 6915 } ,
anchor "apoptosis" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 6468 } ,
anchor "protein amino acid phosphorylation" ,
post-text "evidence: ISS" } } } } } } } } ,
homology {
{
type comment ,
heading "Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 7223 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=11
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d]+AND+gene[obj_type]&QSTR=aatk&cmd=focus&fill=10" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 1197518 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "PROVISIONAL" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 12670708 ,
pmid 12477932 ,
pmid 12466851 ,
pmid 11314039 ,
pmid 11217851 ,
pmid 11076861 ,
pmid 11042159 ,
pmid 10349636 ,
pmid 9444961 } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_007377" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 52345410 } ,
anchor "NM_007377" } } ,
seqs {
whole
gi 52345410 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_031403" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 52345411 } ,
anchor "NP_031403" ,
post-text "apoptosis-associated tyrosine kinase" } } ,
seqs {
whole
gi 52345411 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 52345411 } ,
pre-text "(1)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5392 } ,
anchor "cd00192: TyrKc; Tyrosine kinase, catalytic
domain" } } ,
comment {
{
type other ,
text "Location: 75 - 348 Blast Score: 588" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "BC080846" } ,
anchor "BC080846" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA" ,
accession "AB093253" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 39104554 } ,
anchor "AB093253" } } ,
seqs {
whole
gi 39104554 } ,
products {
{
type peptide ,
accession "BAC41437" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 39104555 } ,
anchor "BAC41437" } } ,
seqs {
whole
gi 39104555 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AF011908" ,
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source {
{
src {
db "Nucleotide" ,
tag
id 2459992 } ,
anchor "AF011908" } } ,
seqs {
whole
gi 2459992 } ,
products {
{
type peptide ,
accession "AAB71837" ,
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source {
{
src {
db "Protein" ,
tag
id 2459993 } ,
anchor "AAB71837" } } ,
seqs {
whole
gi 2459993 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK036705" ,
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source {
{
src {
db "Nucleotide" ,
tag
id 26331621 } ,
anchor "AK036705" } } ,
seqs {
whole
gi 26331621 } ,
products {
{
type peptide ,
accession "BAC29541" ,
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source {
{
src {
db "Protein" ,
tag
id 26331622 } ,
anchor "BAC29541" } } ,
seqs {
whole
gi 26331622 } } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
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source {
{
src {
db "Nucleotide" ,
tag
id 26096668 } ,
anchor "AK076214" } } ,
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whole
gi 26096668 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
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{
type mRNA ,
heading "mRNA" ,
accession "AY236858" ,
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source {
{
src {
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id 29824955 } ,
anchor "AY236858" } } ,
seqs {
whole
gi 29824955 } ,
products {
{
type peptide ,
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source {
{
src {
db "Protein" ,
tag
id 29824956 } ,
anchor "AAO92350" } } ,
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whole
gi 29824956 } } } } ,
{
type mRNA ,
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accession "AY236859" ,
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source {
{
src {
db "Nucleotide" ,
tag
id 29824957 } ,
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seqs {
whole
gi 29824957 } ,
products {
{
type peptide ,
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source {
{
src {
db "Protein" ,
tag
id 29824958 } ,
anchor "AAO92351" } } ,
seqs {
whole
gi 29824958 } } } ,
comment {
{
type other ,
label "Strain" ,
text "129/SvJ" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC042837" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 27769340 } ,
anchor "BC042837" } } ,
seqs {
whole
gi 27769340 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC052323" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 30410866 } ,
anchor "BC052323" } } ,
seqs {
whole
gi 30410866 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC080846" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 51593713 } ,
anchor "BC080846" } } ,
seqs {
whole
gi 51593713 } ,
products {
{
type peptide ,
accession "AAH80846" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 51593714 } ,
anchor "AAH80846" } } ,
seqs {
whole
gi 51593714 } } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6" ,
version 0 } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "11302" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
ig=NT_039521.3&gene=Aatk&lid=11302&from=31407804&to=31422032" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "11302" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
090&contig=NT_039521.3&gene=Aatk&lid=11302" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Mm.6826" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Mm.6826" } ,
anchor "Mm.6826" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=68
26" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "11302" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
11302[loc]&TAXID=10090" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 1197518 } ,
anchor "MGI" ,
url "http://www.informatics.jax.org/searches/accession_report.cg
i?id=MGI:1197518" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Mus_musculus/contigview?geneid=BC052
323" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
BC052323" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGC" ,
tag
str "BC080846" } ,
anchor "MGC" ,
url "http://mgc.nci.nih.gov/Genes/CloneList?ORG=Mm&LIST=BC080846" } } } } } ,
{
type generif ,
text "Expression of AATYK mRNA and protein increased during postnatal
brain development. In immature granule cells, overexpression of AATYK
promoted neurite outgrowth; a tyrosine kinase-defective mutant significantly
inhibited it." ,
version 0 ,
refs {
pmid 12670708 } ,
create-date
str "Jun 17 2003 12:00AM" ,
update-date
str "Aug 3 2003 7:06AM" } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11302 } ,
{
db "MGI" ,
tag
id 1197518 } } ,
xtra-index-terms {
"LOC11302" } }
Entrezgene ::= {
track-info {
geneid 11303 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 19 ,
hour 12 ,
minute 12 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } ,
subtype {
{
subtype chromosome ,
name "4" } } } ,
gene {
locus "Abca1" ,
desc "ATP-binding cassette, sub-family A (ABC1), member 1" ,
maploc "4 23.1 cM" ,
syn {
"Abc1" } ,
locus-tag "MGI:99607" } ,
prot {
name {
"ATP-binding cassette 1, sub-family A, member 1" ,
"ATP-binding cassette 1" } } ,
summary "The membrane-associated protein encoded by this gene is a member of
the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins
transport various molecules across extra- and intracellular membranes. ABC
genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD,
OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members
of the ABC1 subfamily comprise the only major ABC subfamily found exclusively
in multicellular eukaryotes. In humans, this protein functions as a
cholesterol efflux pump in the cellular lipid removal pathway. Mutations in
the human gene have been associated with Tangier's disease and familial
high-density lipoprotein deficiency." ,
location {
{
display-str "4 A5-B3" ,
method
map-type cyto } ,
{
display-str "4 23.1 cM" ,
method
map-type cM } } ,
gene-source {
src "LocusLink" ,
src-int 11303 ,
src-str2 "11303" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000070" ,
version 1 ,
seqs {
int {
from 52275832 ,
to 52404936 ,
strand minus ,
id
gi 51860768 } } ,
products {
{
type mRNA ,
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gi 51860768 } ,
int {
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gi 51860768 } } } ,
seqs {
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gi 34577068 } ,
products {
{
type peptide ,
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accession "NP_038482" ,
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genomic-coords {
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id
gi 51860768 } ,
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strand minus ,
id
gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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gi 51860768 } ,
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strand minus ,
id
gi 51860768 } ,
{
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
{
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
{
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
{
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
{
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strand minus ,
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gi 51860768 } ,
{
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strand minus ,
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gi 51860768 } ,
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strand minus ,
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gi 51860768 } ,
{
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strand minus ,
id
gi 51860768 } ,
{
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strand minus ,
id
gi 51860768 } ,
{
from 52388974 ,
to 52389039 ,
strand minus ,
id
gi 51860768 } } } ,
seqs {
whole
gi 34577069 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_039260" ,
version 3 ,
seqs {
int {
from 26554540 ,
to 26683644 ,
strand minus ,
id
gi 51709342 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_013454" ,
version 2 ,
genomic-coords {
mix {
int {
from 26554540 ,
to 26557835 ,
strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
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strand minus ,
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gi 51709342 } ,
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
from 26574041 ,
to 26574210 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26574687 ,
to 26574761 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26583009 ,
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strand minus ,
id
gi 51709342 } ,
int {
from 26584085 ,
to 26584117 ,
strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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to 26586331 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26589653 ,
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strand minus ,
id
gi 51709342 } ,
int {
from 26590783 ,
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strand minus ,
id
gi 51709342 } ,
int {
from 26592439 ,
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
from 26593828 ,
to 26593876 ,
strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
from 26597972 ,
to 26598192 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26598883 ,
to 26599020 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26599199 ,
to 26599341 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26600643 ,
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strand minus ,
id
gi 51709342 } ,
int {
from 26601695 ,
to 26601866 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26603323 ,
to 26603436 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26604518 ,
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strand minus ,
id
gi 51709342 } ,
int {
from 26605674 ,
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strand minus ,
id
gi 51709342 } ,
int {
from 26607469 ,
to 26607691 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26608136 ,
to 26608312 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26608848 ,
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
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gi 51709342 } ,
int {
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to 26630934 ,
strand minus ,
id
gi 51709342 } ,
int {
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to 26633037 ,
strand minus ,
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gi 51709342 } ,
int {
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strand minus ,
id
gi 51709342 } ,
int {
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to 26652614 ,
strand minus ,
id
gi 51709342 } ,
int {
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to 26656767 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26667682 ,
to 26667847 ,
strand minus ,
id
gi 51709342 } ,
int {
from 26683428 ,
to 26683644 ,
strand minus ,
id
gi 51709342 } } } ,
seqs {
whole
gi 34577068 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_038482" ,
version 2 ,
genomic-coords {
packed-int {
{
from 26557695 ,
to 26557835 ,
strand minus ,
id
gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
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gi 51709342 } ,
{
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
{
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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{
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gi 51709342 } ,
{
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gi 51709342 } ,
{
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id
gi 51709342 } ,
{
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to 26652614 ,
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id
gi 51709342 } ,
{
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to 26656767 ,
strand minus ,
id
gi 51709342 } ,
{
from 26667682 ,
to 26667747 ,
strand minus ,
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gi 51709342 } } } ,
seqs {
whole
gi 34577069 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "Mouse Genome Informatics" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "Abca1" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "ATP-binding cassette, sub-family A (ABC1), member 1" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "MGI" ,
url "http://www.informatics.jax.org/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 5524 } ,
anchor "ATP binding" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16887 } ,
anchor "ATPase activity" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 11559713 } ,
source {
{
src {
db "GO" ,
tag
id 8203 } ,
anchor "cholesterol metabolism" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 11559713 } ,
source {
{
src {
db "GO" ,
tag
id 30301 } ,
anchor "cholesterol transport" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12859204 } ,
source {
{
src {
db "GO" ,
tag
id 42158 } ,
anchor "lipoprotein biosynthesis" ,
post-text "evidence: IMP" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10878804 } ,
source {
{
src {
db "GO" ,
tag
id 6911 } ,
anchor "phagocytosis, engulfment" ,
post-text "evidence: IMP" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10878804 } ,
source {
{
src {
db "GO" ,
tag
id 45332 } ,
anchor "phospholipid translocation" ,
post-text "evidence: IMP" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 6810 } ,
anchor "transport" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 10878804 } ,
source {
{
src {
db "GO" ,
tag
id 5794 } ,
anchor "Golgi apparatus" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 16021 } ,
anchor "integral to membrane" ,
post-text "evidence: TAS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10878804 } ,
source {
{
src {
db "GO" ,
tag
id 5887 } ,
anchor "integral to plasma membrane" ,
post-text "evidence: IDA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10878804 } ,
source {
{
src {
db "GO" ,
tag
id 43231 } ,
anchor "intracellular membrane-bound organelle" ,
post-text "evidence: IDA" } } } } } } } } ,
homology {
{
type comment ,
heading "Human, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 21130 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=4&
MAPS=genes-r-org/human-chr/mouse%3A4,genes-r-org/rat-chr/mouse%3A4,genes-r-org
/mouse-chr4&query=e%3A11303[id]+AND+gene[obj_type]&QSTR=abca1&cmd=focus&fill=1
0" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 99607 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 15632021 ,
pmid 15269218 ,
pmid 15269217 ,
pmid 15163665 ,
pmid 15051721 ,
pmid 15033469 ,
pmid 15026428 ,
pmid 14993246 ,
pmid 14729855 ,
pmid 14726413 ,
pmid 14722086 ,
pmid 14703508 ,
pmid 14560020 ,
pmid 14559902 ,
pmid 12928428 ,
pmid 12897186 ,
pmid 12897148 ,
pmid 12859204 ,
pmid 12777468 ,
pmid 12754274 ,
pmid 12615679 ,
pmid 12586783 ,
pmid 12576511 ,
pmid 12551894 ,
pmid 12547832 ,
pmid 12511593 ,
pmid 12488454 ,
pmid 12487373 ,
pmid 12466851 ,
pmid 12384498 ,
pmid 12215451 ,
pmid 12196520 ,
pmid 12151852 ,
pmid 12105210 ,
pmid 12050168 ,
pmid 11972062 ,
pmid 11909955 ,
pmid 11896206 ,
pmid 11893753 ,
pmid 11752403 ,
pmid 11741998 ,
pmid 11559713 ,
pmid 11352567 ,
pmid 11217851 ,
pmid 11076861 ,
pmid 11042159 ,
pmid 10878804 ,
pmid 10760292 ,
pmid 10655069 ,
pmid 10581369 ,
pmid 10349636 ,
pmid 8889548 ,
pmid 8088782 ,
pmid 7774911 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 179001 } ,
anchor "X75926" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "3512" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "ND" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 271599 } ,
anchor "PMC16657P1" ,
post-text "(e-PCR)" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 271951 } ,
anchor "PMC207565P1" ,
post-text "(e-PCR)" } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_013454" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 34577068 } ,
anchor "NM_013454" } } ,
seqs {
whole
gi 34577068 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_038482" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 34577069 } ,
anchor "NP_038482" ,
post-text "ATP-binding cassette 1, sub-family A, member 1" } } ,
seqs {
whole
gi 34577069 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 34577069 } ,
pre-text "(3)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5341 } ,
anchor "cd00267: ABC_ATPase; ABC (ATP-binding
cassette) transporter nucleotide-binding domain" } } ,
comment {
{
type other ,
text "Location: 899 - 1114 Blast Score: 462" ,
version 0 } ,
{
type other ,
text "Location: 1912 - 2121 Blast Score: 356" ,
version 0 } } } ,
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 13428 } ,
anchor "COG4152: COG4152; ABC-type uncharacterized
transport system, ATPase component [General function prediction only]" } } ,
comment {
{
type other ,
text "Location: 1912 - 2218 Blast Score: 360" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "AK045442,BB657864,CA885568,X75926" } ,
anchor "AK045442,BB657864,CA885568,X75926" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "AF287263" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 11611824 } ,
anchor "AF287263" } } ,
seqs {
whole
gi 11611824 } ,
products {
{
type peptide ,
accession "AAG39073" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 11611825 } ,
anchor "AAG39073" } } ,
seqs {
whole
gi 11611825 } } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK019548" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 12859824 } ,
anchor "AK019548" } } ,
seqs {
whole
gi 12859824 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK045442" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 26090897 } ,
anchor "AK045442" } } ,
seqs {
whole
gi 26090897 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK051920" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 26342297 } ,
anchor "AK051920" } } ,
seqs {
whole
gi 26342297 } ,
products {
{
type peptide ,
accession "BAC34811" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 26342298 } ,
anchor "BAC34811" } } ,
seqs {
whole
gi 26342298 } } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BB657864" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 16491690 } ,
anchor "BB657864" } } ,
seqs {
whole
gi 16491690 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "CA885568" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 27337117 } ,
anchor "CA885568" } } ,
seqs {
whole
gi 27337117 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } ,
comment {
{
type other ,
label "Strain" ,
text "CD-1" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "X75926" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 495256 } ,
anchor "X75926" } } ,
seqs {
whole
gi 495256 } ,
products {
{
type peptide ,
accession "CAA53530" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 495257 } ,
anchor "CAA53530" } } ,
seqs {
whole
gi 495257 } } } ,
comment {
{
type other ,
label "Strain" ,
text "DBA/2" ,
version 0 } } } ,
{
type other ,
text "None" ,
version 0 ,
products {
{
type peptide ,
accession "P41233" ,
version 0 ,
source {
{
src {
db "Protein" ,
tag
id 51338775 } ,
anchor "P41233" } } ,
seqs {
whole
gi 51338775 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "11303" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
ig=NT_039260.3&gene=Abca1&lid=11303&from=26554541&to=26683645" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "11303" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
090&contig=NT_039260.3&gene=Abca1&lid=11303" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Mm.277376" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Mm.277376" } ,
anchor "Mm.277376" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=27
7376" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "11303" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
11303[loc]&TAXID=10090" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 99607 } ,
anchor "MGI" ,
url "http://www.informatics.jax.org/searches/accession_report.cg
i?id=MGI:99607" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Mus_musculus/contigview?geneid=X7592
6" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
X75926" } } } ,
{
type comment ,
text "Gene Expression Database (GXD) at MGI" ,
version 0 ,
source {
{
src {
db "Gene Expression Database (GXD) at MGI" ,
tag
str "MGI:99607" } ,
anchor "MGI:99607" ,
url "http://www.informatics.jax.org/searches/expression_report.c
gi?id=MGI:99607" } } } ,
{
type comment ,
text "Human ABC-Transporter Proteins" ,
version 0 ,
source {
{
src {
db "Human ABC-Transporter Proteins" ,
tag
str "Human ABC-Transporter Proteins" } ,
anchor "Human ABC-Transporter Proteins" ,
url "http://nutrigene.4t.com/humanabc.htm" } } } } } ,
{
type generif ,
text "Gene deletion protects aginst cerebral malaria from Plasmodium
berghei." ,
version 0 ,
refs {
pmid 15632021 } ,
create-date
str "Mar 7 2005 7:07PM" ,
update-date
str "Mar 8 2005 3:26AM" } ,
{
type generif ,
text "ABCA1-dependent cholesterol mobilization to apoA-I increased new
cholesterol synthesis, indicating depletion of the regulatory pool of
hepatocyte cholesterol during HDL formation" ,
version 0 ,
refs {
pmid 14993246 } ,
create-date
str "Mar 7 2005 7:07PM" ,
update-date
str "Mar 8 2005 12:40AM" } ,
{
type generif ,
text "a 21% decrease (P = 0.01) in fertility was observed between
ABCA1(-/-) males compared with WT controls across their reproductive
lifespans" ,
version 0 ,
refs {
pmid 15026428 } ,
create-date
str "Mar 7 2005 7:07PM" ,
update-date
str "Mar 7 2005 9:28PM" } ,
{
type generif ,
text "Verapamil increases ABCA1 expression through LXR-independent
mechanism and thereby increases apoA-I-mediated cellular lipid release and
production of HDL." ,
version 0 ,
refs {
pmid 14726413 } ,
create-date
str "Jan 8 2005 10:01AM" ,
update-date
str "Jan 8 2005 2:49PM" } ,
{
type generif ,
text "In murine macrophage cell line RAW264 cells, cAMP induced
expression of ABCA1, release of cellular phospholipid and cholesterol by
apoA-I, and reversible binding of apoA-I to the cell." ,
version 0 ,
refs {
pmid 14729855 } ,
create-date
str "Dec 4 2004 10:01AM" ,
update-date
str "Dec 4 2004 2:26PM" } ,
{
type generif ,
text "The time course and temperature dependence of ABCA1-mediated lipid
efflux to apoA-I support a role for endocytosis in this process" ,
version 0 ,
refs {
pmid 14703508 } ,
create-date
str "Dec 4 2004 10:01AM" ,
update-date
str "Dec 4 2004 11:09AM" } ,
{
type generif ,
text "conclude that intact ATP binding cassette transporter A1 (ABCA1)
function is necessary for proper maturation of dense bodies in platelets" ,
version 0 ,
refs {
pmid 15163665 } ,
create-date
str "Oct 30 2004 10:01AM" ,
update-date
str "Oct 30 2004 10:58AM" } ,
{
type generif ,
text "glial ABCA1 has a key role in apoE metabolism in the brain" ,
version 0 ,
refs {
pmid 15269218 } ,
create-date
str "Oct 30 2004 10:01AM" ,
update-date
str "Oct 30 2004 10:43AM" } ,
{
type generif ,
text "ABCA1 plays a critical role in central nervous system apoE
metabolism" ,
version 0 ,
refs {
pmid 15269217 } ,
create-date
str "Oct 30 2004 10:01AM" ,
update-date
str "Oct 30 2004 10:43AM" } ,
{
type generif ,
text "PPAR alpha influences cholesterol absorption through modulating
the ATP binding cassette transporter A1 activity in the intestine by a
mechanism involving liver X receptor alpha" ,
version 0 ,
refs {
pmid 12897186 } ,
create-date
str "Aug 9 2004 1:01PM" ,
update-date
str "Aug 9 2004 1:41PM" } ,
{
type generif ,
text "When endotoxin or cytokines (tumor necrosis factor and
interleukin-1) were incubated with J774 murine macrophages, the mRNA levels
of ABCA1 were decreased." ,
version 0 ,
refs {
pmid 12777468 } ,
create-date
str "Jul 12 2004 11:39AM" ,
update-date
str "Jul 12 2004 12:16PM" } ,
{
type generif ,
text "ABCA1 is stabilized by a specific structural element possessing a
linear array of acidic residues spanning two apoA-I amphipathic alpha-helices" ,
version 0 ,
refs {
pmid 15051721 } ,
create-date
str "Jul 12 2004 11:39AM" ,
update-date
str "Jul 12 2004 11:52AM" } ,
{
type generif ,
text "despite large induction of ABCA1 mRNA during differentiation,
cholesterol efflux through the ABCA1 pathway remains limited in adipocytes
and requires prolonged lipolysis" ,
version 0 ,
refs {
pmid 12754274 } ,
create-date
str "Jun 23 2004 4:43PM" ,
update-date
str "Jun 23 2004 5:25PM" } ,
{
type generif ,
text "ABCA1 turnover is modulated by alpha1-syntrophin" ,
version 0 ,
refs {
pmid 14722086 } ,
create-date
str "Jun 14 2004 4:41PM" ,
update-date
str "Jun 14 2004 5:46PM" } ,
{
type generif ,
text "Review. ABCA1-deficient mice are used to demonstrate the relation
between ABCA1 expression, cellular lipid efflux, & HDL metabolism. The
ABCA1-deficient mouse phenotype parallels that of human Tangier disease." ,
version 0 ,
refs {
pmid 12615679 } ,
create-date
str "Jan 25 2004 12:00AM" ,
update-date
str "Feb 29 2004 7:03AM" } ,
{
type generif ,
text "cellular ATP-binding cassette transporter A1 has a role in
transporting cholesterol and phospholipids from cells to lipoprotein
particles by a process involving PLTP interactions" ,
version 0 ,
refs {
pmid 14559902 } ,
create-date
str "Jan 20 2004 12:00AM" ,
update-date
str "Feb 15 2004 6:35PM" } ,
{
type generif ,
text "Results demonstrate that ABCA1 plays a key role in hepatic
cholesterol efflux, inducing pathways that modulate cholesterol homeostasis
in the liver, and establish the liver as a major source of plasma HDL-C." ,
version 0 ,
refs {
pmid 12576511 } ,
create-date
str "Jan 5 2004 12:00AM" ,
update-date
str "Feb 29 2004 7:03AM" } ,
{
type generif ,
text "ABCA1-mediated vesicle release involves lipid raft plasma membrane
domains" ,
version 0 ,
refs {
pmid 12928428 } ,
create-date
str "Nov 30 2003 12:00AM" ,
update-date
str "Jan 4 2004 7:03AM" } ,
{
type generif ,
text "These studies indicate a direct role of retinoic acid receptor
gamma/retinoid x receptor in induction of macrophage ABCA1." ,
version 0 ,
refs {
pmid 14560020 } ,
create-date
str "Nov 17 2003 12:00AM" ,
update-date
str "Dec 7 2003 7:05AM" } ,
{
type generif ,
text "As observed in knockout mice, ABCA1 is necessary for the adequate
lipidation of apoAI, which enables the interaction with LCAT and subsequent
maturation." ,
version 0 ,
refs {
pmid 12859204 } ,
create-date
str "Sep 30 2003 12:00AM" ,
update-date
str "Oct 12 2003 7:03AM" } ,
{
type generif ,
text "ABCA1 and SREBP1 are regulated by liver X receptor/corepressor
complexes" ,
version 0 ,
refs {
pmid 12897148 } ,
create-date
str "Aug 25 2003 12:00AM" ,
update-date
str "Aug 31 2003 7:04AM" } ,
{
type generif ,
text "Estrogen's antiatherogenic effects may occur via ABCA1-mediated
pathway, and circulating HDL levels may influence expression of ABCA1" ,
version 0 ,
refs {
pmid 12487373 } ,
create-date
str "Jun 3 2003 12:00AM" ,
update-date
str "Jun 8 2003 7:28AM" } ,
{
type generif ,
text "Hepatocyte expression of ABCA1 is central to the lipidation of
newly synthesized apoA-I but also contributes to the lipidation of exogenous
apoA-I." ,
version 0 ,
refs {
pmid 12547832 } ,
create-date
str "Apr 2 2003 12:00AM" ,
update-date
str "May 11 2003 7:05AM" } ,
{
type generif ,
text "Golgi is involved in ABCA1-mediated cholesterol efflux." ,
version 0 ,
refs {
pmid 12551894 } ,
create-date
str "Apr 1 2003 12:00AM" ,
update-date
str "May 11 2003 7:05AM" } ,
{
type generif ,
text "ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux
is promoted by central helices of ApoA-I; amino acid residues 220-231 of the
wild-type ApoA-I are required for lipid efflux and high density lipoprotein
formation" ,
version 0 ,
refs {
pmid 12488454 } ,
create-date
str "Mar 20 2003 12:00AM" ,
update-date
str "Apr 13 2003 7:04AM" } ,
{
type generif ,
text "annexin I is externalized from pituitary folliculo-stellate cells
by an ABC transporter and the ATP binding cassette transporter A1 is a likely
candidate" ,
version 0 ,
refs {
pmid 12586783 } ,
create-date
str "Mar 19 2003 12:00AM" ,
update-date
str "Mar 31 2003 6:34AM" } ,
{
type generif ,
text "ATP-binding-cassette transporter A1 gene expression in macrophages
is downregulated by statins" ,
version 0 ,
refs {
pmid 15033469 } ,
create-date
str "Apr 26 2004 12:00AM" ,
update-date
str "May 23 2004 7:05AM" } ,
{
type generif ,
text "ABCA1 is regulated by PEST sequence-mediated calpain proteolysis
that appears to be reversed by apolipoprotein-mediated phospholipid efflux" ,
version 0 ,
refs {
pmid 12511593 } ,
create-date
str "Feb 7 2003 12:00AM" ,
update-date
str "Mar 9 2003 7:04AM" } ,
{
type generif ,
text "REVIEW: ATP-binding cassette transporter A1 and cholesterol
trafficking" ,
version 0 ,
refs {
pmid 12151852 } ,
create-date
str "Jan 24 2003 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "mediates cholesterol efflux and is defective in free
cholesterol-loaded macrophages; mechanism involves enhanced degradation and
full npc1 activity." ,
version 0 ,
refs {
pmid 12215451 } ,
create-date
str "Jan 16 2003 12:00AM" ,
update-date
str "Feb 9 2003 7:14AM" } ,
{
type generif ,
text "induction as a result of liver X receptor agonism increases
secreted Abeta levels" ,
version 0 ,
refs {
pmid 12384498 } ,
create-date
str "Jan 9 2003 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "Increased hepatobiliary and fecal cholesterol excretion upon
activation of the liver X receptor is independent of ABCA1." ,
version 0 ,
refs {
pmid 12105210 } ,
create-date
str "Nov 20 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "A novel serine (Ser-2054) on the ABCA1 protein crucial for PKA
phosphorylation and for regulation of ABCA1 transporter activity." ,
version 0 ,
refs {
pmid 12196520 } ,
create-date
str "Nov 16 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:50AM" } ,
{
type generif ,
text "studies establish a novel binding site for apoA-I on the
macrophage extracellular matrix that may function together with ABCA1 in
promoting cholesterol efflux" ,
version 0 ,
refs {
pmid 12050168 } ,
create-date
str "Sep 27 2002 12:00AM" ,
update-date
str "Feb 2 2003 7:49AM" } ,
{
type generif ,
text "Role as a phosphatidylserine translocase" ,
version 0 ,
refs {
pmid 11893753 } ,
create-date
str "Jul 8 2002 12:00AM" ,
update-date
str "Jul 22 2002 5:59AM" } ,
{
type generif ,
text "Leukocyte ABCA1 controls susceptibility to atherosclerosis and
macrophage recruitment into tissues" ,
version 0 ,
refs {
pmid 11972062 } ,
create-date
str "May 31 2002 12:00AM" ,
update-date
str "Jun 15 2002 8:10AM" } ,
{
type generif ,
text "Conditional disruption of the peroxisome proliferator-activated
receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1,
and apoE in macrophages and reduced cholesterol efflux." ,
version 0 ,
refs {
pmid 11909955 } ,
create-date
str "Apr 16 2002 12:00AM" ,
update-date
str "Apr 28 2002 6:21PM" } ,
{
type generif ,
text "in the presence of apoE, overexpression of ABCA1 modulates HDL as
well as apoB-containing lipoprotein metabolism and reduces atherosclerosis in
vivo" ,
version 0 ,
refs {
pmid 11752403 } ,
create-date
str "Apr 2 2002 12:00AM" ,
update-date
str "Apr 28 2002 6:21PM" } ,
{
type generif ,
text "ABCA1 is expressed in a pattern consistent with its role in HDL-C
metabolism" ,
version 0 ,
refs {
pmid 11896206 } ,
create-date
str "Mar 27 2002 12:00AM" ,
update-date
str "Apr 8 2002 3:24PM" } ,
{
type generif ,
text "unsaturated fatty acids reduce the macrophage ABCA1 content by
enhancing its degradation rate" ,
version 0 ,
refs {
pmid 11741998 } ,
create-date
str "Mar 5 2002 12:00AM" ,
update-date
str "Apr 1 2002 5:34AM" } ,
{
type comment ,
heading "Alleles" ,
version 0 ,
comment {
{
type comment ,
text "The following allele types are documented at Mouse Genome
Informatics" ,
version 0 ,
source {
{
anchor "(MGI)" ,
url "http://www.informatics.jax.org/searches/allele_report.cgi?m
arkerID=MGI:99607" } } } ,
{
type comment ,
heading "Targeted (knock-out) (2)" ,
version 0 ,
refs {
pmid 10760292 ,
pmid 10980140 } } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11303 } ,
{
db "MGI" ,
tag
id 99607 } } ,
xtra-index-terms {
"LOC11303" } }
Entrezgene ::= {
track-info {
geneid 11304 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 15 ,
hour 9 ,
minute 44 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } ,
subtype {
{
subtype chromosome ,
name "3" } } } ,
gene {
locus "Abca4" ,
desc "ATP-binding cassette, sub-family A (ABC1), member 4" ,
maploc "3 61.8 cM" ,
syn {
"RmP" ,
"Abcr" ,
"Abc10" ,
"D430003I15Rik" } ,
locus-tag "MGI:109424" } ,
prot {
name {
"ATP-binding cassette, sub-family A, member 4" ,
"Rim protein" ,
"ATP-binding cassette 10" } } ,
summary "The membrane-associated protein encoded by this gene is a member of
the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins
transport various molecules across extra- and intracellular membranes. ABC
genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD,
OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members
of the ABC1 subfamily comprise the only major ABC subfamily found exclusively
in multicellular eukaryotes. This protein was the first of the ABC
transporters to be observed in photoreceptors and may play a role in the
photoresponse. Mutations in the human gene are found in patients diagnosed
with Stargardt disease and are associated with retinitis pigmentosa-19 and
macular degeneration age-related 2." ,
location {
{
display-str "3 G1" ,
method
map-type cyto } ,
{
display-str "3 61.8 cM" ,
method
map-type cM } } ,
gene-source {
src "LocusLink" ,
src-int 11304 ,
src-str2 "11304" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000069" ,
version 1 ,
seqs {
int {
from 122426366 ,
to 122561663 ,
strand plus ,
id
gi 51860767 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_007378" ,
version 1 ,
genomic-coords {
mix {
int {
from 122426366 ,
to 122426518 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122434867 ,
to 122434960 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122436157 ,
to 122436298 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122437283 ,
to 122437422 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122444741 ,
to 122444868 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122451134 ,
to 122451331 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122462504 ,
to 122462593 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122465447 ,
to 122465687 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122467129 ,
to 122467268 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122468154 ,
to 122468270 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122468889 ,
to 122469086 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122484278 ,
to 122484483 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122485037 ,
to 122485213 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122486910 ,
to 122487132 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122492064 ,
to 122492285 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122493968 ,
to 122494172 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122498257 ,
to 122498322 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122501632 ,
to 122501721 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122503233 ,
to 122503407 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122505161 ,
to 122505292 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122507723 ,
to 122507862 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122508424 ,
to 122508561 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122509727 ,
to 122509920 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122510918 ,
to 122511002 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122514126 ,
to 122514331 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122514655 ,
to 122514703 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122516604 ,
to 122516866 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122518583 ,
to 122518707 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122519172 ,
to 122519270 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122520026 ,
to 122520212 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122523293 ,
to 122523387 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122525002 ,
to 122525034 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122528800 ,
to 122528905 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122529033 ,
to 122529107 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122529332 ,
to 122529501 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122530477 ,
to 122530654 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122536879 ,
to 122536994 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122537940 ,
to 122538087 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122539437 ,
to 122539560 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122539916 ,
to 122540045 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122543903 ,
to 122544023 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122544463 ,
to 122544525 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122545390 ,
to 122545496 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122548250 ,
to 122548391 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122551495 ,
to 122551629 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122552344 ,
to 122552447 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122552531 ,
to 122552623 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122555381 ,
to 122555630 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122557676 ,
to 122557762 ,
strand plus ,
id
gi 51860767 } ,
int {
from 122561316 ,
to 122561663 ,
strand plus ,
id
gi 51860767 } } } ,
seqs {
whole
gi 6671494 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_031404" ,
version 1 ,
genomic-coords {
packed-int {
{
from 122426453 ,
to 122426518 ,
strand plus ,
id
gi 51860767 } ,
{
from 122434867 ,
to 122434960 ,
strand plus ,
id
gi 51860767 } ,
{
from 122436157 ,
to 122436298 ,
strand plus ,
id
gi 51860767 } ,
{
from 122437283 ,
to 122437422 ,
strand plus ,
id
gi 51860767 } ,
{
from 122444741 ,
to 122444868 ,
strand plus ,
id
gi 51860767 } ,
{
from 122451134 ,
to 122451331 ,
strand plus ,
id
gi 51860767 } ,
{
from 122462504 ,
to 122462593 ,
strand plus ,
id
gi 51860767 } ,
{
from 122465447 ,
to 122465687 ,
strand plus ,
id
gi 51860767 } ,
{
from 122467129 ,
to 122467268 ,
strand plus ,
id
gi 51860767 } ,
{
from 122468154 ,
to 122468270 ,
strand plus ,
id
gi 51860767 } ,
{
from 122468889 ,
to 122469086 ,
strand plus ,
id
gi 51860767 } ,
{
from 122484278 ,
to 122484483 ,
strand plus ,
id
gi 51860767 } ,
{
from 122485037 ,
to 122485213 ,
strand plus ,
id
gi 51860767 } ,
{
from 122486910 ,
to 122487132 ,
strand plus ,
id
gi 51860767 } ,
{
from 122492064 ,
to 122492285 ,
strand plus ,
id
gi 51860767 } ,
{
from 122493968 ,
to 122494172 ,
strand plus ,
id
gi 51860767 } ,
{
from 122498257 ,
to 122498322 ,
strand plus ,
id
gi 51860767 } ,
{
from 122501632 ,
to 122501721 ,
strand plus ,
id
gi 51860767 } ,
{
from 122503233 ,
to 122503407 ,
strand plus ,
id
gi 51860767 } ,
{
from 122505161 ,
to 122505292 ,
strand plus ,
id
gi 51860767 } ,
{
from 122507723 ,
to 122507862 ,
strand plus ,
id
gi 51860767 } ,
{
from 122508424 ,
to 122508561 ,
strand plus ,
id
gi 51860767 } ,
{
from 122509727 ,
to 122509920 ,
strand plus ,
id
gi 51860767 } ,
{
from 122510918 ,
to 122511002 ,
strand plus ,
id
gi 51860767 } ,
{
from 122514126 ,
to 122514331 ,
strand plus ,
id
gi 51860767 } ,
{
from 122514655 ,
to 122514703 ,
strand plus ,
id
gi 51860767 } ,
{
from 122516604 ,
to 122516866 ,
strand plus ,
id
gi 51860767 } ,
{
from 122518583 ,
to 122518707 ,
strand plus ,
id
gi 51860767 } ,
{
from 122519172 ,
to 122519270 ,
strand plus ,
id
gi 51860767 } ,
{
from 122520026 ,
to 122520212 ,
strand plus ,
id
gi 51860767 } ,
{
from 122523293 ,
to 122523387 ,
strand plus ,
id
gi 51860767 } ,
{
from 122525002 ,
to 122525034 ,
strand plus ,
id
gi 51860767 } ,
{
from 122528800 ,
to 122528905 ,
strand plus ,
id
gi 51860767 } ,
{
from 122529033 ,
to 122529107 ,
strand plus ,
id
gi 51860767 } ,
{
from 122529332 ,
to 122529501 ,
strand plus ,
id
gi 51860767 } ,
{
from 122530477 ,
to 122530654 ,
strand plus ,
id
gi 51860767 } ,
{
from 122536879 ,
to 122536994 ,
strand plus ,
id
gi 51860767 } ,
{
from 122537940 ,
to 122538087 ,
strand plus ,
id
gi 51860767 } ,
{
from 122539437 ,
to 122539560 ,
strand plus ,
id
gi 51860767 } ,
{
from 122539916 ,
to 122540045 ,
strand plus ,
id
gi 51860767 } ,
{
from 122543903 ,
to 122544023 ,
strand plus ,
id
gi 51860767 } ,
{
from 122544463 ,
to 122544525 ,
strand plus ,
id
gi 51860767 } ,
{
from 122545390 ,
to 122545496 ,
strand plus ,
id
gi 51860767 } ,
{
from 122548250 ,
to 122548391 ,
strand plus ,
id
gi 51860767 } ,
{
from 122551495 ,
to 122551629 ,
strand plus ,
id
gi 51860767 } ,
{
from 122552344 ,
to 122552447 ,
strand plus ,
id
gi 51860767 } ,
{
from 122552531 ,
to 122552623 ,
strand plus ,
id
gi 51860767 } ,
{
from 122555381 ,
to 122555630 ,
strand plus ,
id
gi 51860767 } ,
{
from 122557676 ,
to 122557762 ,
strand plus ,
id
gi 51860767 } ,
{
from 122561316 ,
to 122561435 ,
strand plus ,
id
gi 51860767 } } } ,
seqs {
whole
gi 6671495 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_039240" ,
version 3 ,
seqs {
int {
from 8569036 ,
to 8704333 ,
strand plus ,
id
gi 51708444 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_007378" ,
version 1 ,
genomic-coords {
mix {
int {
from 8569036 ,
to 8569188 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8577537 ,
to 8577630 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8578827 ,
to 8578968 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8579953 ,
to 8580092 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8587411 ,
to 8587538 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8593804 ,
to 8594001 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8605174 ,
to 8605263 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8608117 ,
to 8608357 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8609799 ,
to 8609938 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8610824 ,
to 8610940 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8611559 ,
to 8611756 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8626948 ,
to 8627153 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8627707 ,
to 8627883 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8629580 ,
to 8629802 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8634734 ,
to 8634955 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8636638 ,
to 8636842 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8640927 ,
to 8640992 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8644302 ,
to 8644391 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8645903 ,
to 8646077 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8647831 ,
to 8647962 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8650393 ,
to 8650532 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8651094 ,
to 8651231 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8652397 ,
to 8652590 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8653588 ,
to 8653672 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8656796 ,
to 8657001 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8657325 ,
to 8657373 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8659274 ,
to 8659536 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8661253 ,
to 8661377 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8661842 ,
to 8661940 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8662696 ,
to 8662882 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8665963 ,
to 8666057 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8667672 ,
to 8667704 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8671470 ,
to 8671575 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8671703 ,
to 8671777 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8672002 ,
to 8672171 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8673147 ,
to 8673324 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8679549 ,
to 8679664 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8680610 ,
to 8680757 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8682107 ,
to 8682230 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8682586 ,
to 8682715 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8686573 ,
to 8686693 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8687133 ,
to 8687195 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8688060 ,
to 8688166 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8690920 ,
to 8691061 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8694165 ,
to 8694299 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8695014 ,
to 8695117 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8695201 ,
to 8695293 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8698051 ,
to 8698300 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8700346 ,
to 8700432 ,
strand plus ,
id
gi 51708444 } ,
int {
from 8703986 ,
to 8704333 ,
strand plus ,
id
gi 51708444 } } } ,
seqs {
whole
gi 6671494 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_031404" ,
version 1 ,
genomic-coords {
packed-int {
{
from 8569123 ,
to 8569188 ,
strand plus ,
id
gi 51708444 } ,
{
from 8577537 ,
to 8577630 ,
strand plus ,
id
gi 51708444 } ,
{
from 8578827 ,
to 8578968 ,
strand plus ,
id
gi 51708444 } ,
{
from 8579953 ,
to 8580092 ,
strand plus ,
id
gi 51708444 } ,
{
from 8587411 ,
to 8587538 ,
strand plus ,
id
gi 51708444 } ,
{
from 8593804 ,
to 8594001 ,
strand plus ,
id
gi 51708444 } ,
{
from 8605174 ,
to 8605263 ,
strand plus ,
id
gi 51708444 } ,
{
from 8608117 ,
to 8608357 ,
strand plus ,
id
gi 51708444 } ,
{
from 8609799 ,
to 8609938 ,
strand plus ,
id
gi 51708444 } ,
{
from 8610824 ,
to 8610940 ,
strand plus ,
id
gi 51708444 } ,
{
from 8611559 ,
to 8611756 ,
strand plus ,
id
gi 51708444 } ,
{
from 8626948 ,
to 8627153 ,
strand plus ,
id
gi 51708444 } ,
{
from 8627707 ,
to 8627883 ,
strand plus ,
id
gi 51708444 } ,
{
from 8629580 ,
to 8629802 ,
strand plus ,
id
gi 51708444 } ,
{
from 8634734 ,
to 8634955 ,
strand plus ,
id
gi 51708444 } ,
{
from 8636638 ,
to 8636842 ,
strand plus ,
id
gi 51708444 } ,
{
from 8640927 ,
to 8640992 ,
strand plus ,
id
gi 51708444 } ,
{
from 8644302 ,
to 8644391 ,
strand plus ,
id
gi 51708444 } ,
{
from 8645903 ,
to 8646077 ,
strand plus ,
id
gi 51708444 } ,
{
from 8647831 ,
to 8647962 ,
strand plus ,
id
gi 51708444 } ,
{
from 8650393 ,
to 8650532 ,
strand plus ,
id
gi 51708444 } ,
{
from 8651094 ,
to 8651231 ,
strand plus ,
id
gi 51708444 } ,
{
from 8652397 ,
to 8652590 ,
strand plus ,
id
gi 51708444 } ,
{
from 8653588 ,
to 8653672 ,
strand plus ,
id
gi 51708444 } ,
{
from 8656796 ,
to 8657001 ,
strand plus ,
id
gi 51708444 } ,
{
from 8657325 ,
to 8657373 ,
strand plus ,
id
gi 51708444 } ,
{
from 8659274 ,
to 8659536 ,
strand plus ,
id
gi 51708444 } ,
{
from 8661253 ,
to 8661377 ,
strand plus ,
id
gi 51708444 } ,
{
from 8661842 ,
to 8661940 ,
strand plus ,
id
gi 51708444 } ,
{
from 8662696 ,
to 8662882 ,
strand plus ,
id
gi 51708444 } ,
{
from 8665963 ,
to 8666057 ,
strand plus ,
id
gi 51708444 } ,
{
from 8667672 ,
to 8667704 ,
strand plus ,
id
gi 51708444 } ,
{
from 8671470 ,
to 8671575 ,
strand plus ,
id
gi 51708444 } ,
{
from 8671703 ,
to 8671777 ,
strand plus ,
id
gi 51708444 } ,
{
from 8672002 ,
to 8672171 ,
strand plus ,
id
gi 51708444 } ,
{
from 8673147 ,
to 8673324 ,
strand plus ,
id
gi 51708444 } ,
{
from 8679549 ,
to 8679664 ,
strand plus ,
id
gi 51708444 } ,
{
from 8680610 ,
to 8680757 ,
strand plus ,
id
gi 51708444 } ,
{
from 8682107 ,
to 8682230 ,
strand plus ,
id
gi 51708444 } ,
{
from 8682586 ,
to 8682715 ,
strand plus ,
id
gi 51708444 } ,
{
from 8686573 ,
to 8686693 ,
strand plus ,
id
gi 51708444 } ,
{
from 8687133 ,
to 8687195 ,
strand plus ,
id
gi 51708444 } ,
{
from 8688060 ,
to 8688166 ,
strand plus ,
id
gi 51708444 } ,
{
from 8690920 ,
to 8691061 ,
strand plus ,
id
gi 51708444 } ,
{
from 8694165 ,
to 8694299 ,
strand plus ,
id
gi 51708444 } ,
{
from 8695014 ,
to 8695117 ,
strand plus ,
id
gi 51708444 } ,
{
from 8695201 ,
to 8695293 ,
strand plus ,
id
gi 51708444 } ,
{
from 8698051 ,
to 8698300 ,
strand plus ,
id
gi 51708444 } ,
{
from 8700346 ,
to 8700432 ,
strand plus ,
id
gi 51708444 } ,
{
from 8703986 ,
to 8704105 ,
strand plus ,
id
gi 51708444 } } } ,
seqs {
whole
gi 6671495 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "Mouse Genome Informatics" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "Abca4" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "ATP-binding cassette, sub-family A (ABC1), member 4" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "MGI" ,
url "http://www.informatics.jax.org/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 5524 } ,
anchor "ATP binding" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16887 } ,
anchor "ATPase activity" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 9202155 } ,
source {
{
src {
db "GO" ,
tag
id 42626 } ,
anchor "ATPase activity, coupled to transmembrane movement
of substances" ,
post-text "evidence: TAS" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10412977 } ,
source {
{
src {
db "GO" ,
tag
id 5548 } ,
anchor "phospholipid transporter activity" ,
post-text "evidence: IMP" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10412977 } ,
source {
{
src {
db "GO" ,
tag
id 4012 } ,
anchor "phospholipid-translocating ATPase activity" ,
post-text "evidence: IMP" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 10412977 } ,
source {
{
src {
db "GO" ,
tag
id 6649 } ,
anchor "phospholipid transfer to membrane" ,
post-text "evidence: IMP" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 11431429 } ,
source {
{
src {
db "GO" ,
tag
id 45494 } ,
anchor "photoreceptor maintenance" ,
post-text "evidence: IMP" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 7600 } ,
anchor "sensory perception" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 6810 } ,
anchor "transport" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 10412977 } ,
source {
{
src {
db "GO" ,
tag
id 7601 } ,
anchor "visual perception" ,
post-text "evidence: IMP" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16021 } ,
anchor "integral to membrane" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 9202155 } ,
source {
{
src {
db "GO" ,
tag
id 5887 } ,
anchor "integral to plasma membrane" ,
post-text "evidence: TAS" } } } } } } } } ,
homology {
{
type comment ,
heading "Human, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 298 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=3&
MAPS=genes-r-org/human-chr/mouse%3A3,genes-r-org/rat-chr/mouse%3A3,genes-r-org
/mouse-chr3&query=e%3A11304[id]+AND+gene[obj_type]&QSTR=abca4&cmd=focus&fill=1
0" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 109424 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "REVIEWED" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 12477932 ,
pmid 12466851 ,
pmid 11431429 ,
pmid 11217851 ,
pmid 11076861 ,
pmid 11042159 ,
pmid 10852960 ,
pmid 10412977 ,
pmid 10349636 ,
pmid 9202155 ,
pmid 8889548 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 140994 } ,
anchor "Abca4" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "MGI:8523" ,
version 0 } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 159184 } ,
anchor "AF000149" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "192133" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "693384" ,
version 0 } ,
{
type other ,
label "Alternate name" ,
text "ND" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_007378" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 6671494 } ,
anchor "NM_007378" } } ,
seqs {
whole
gi 6671494 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_031404" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 6671495 } ,
anchor "NP_031404" ,
post-text "ATP-binding cassette, sub-family A, member 4" } } ,
seqs {
whole
gi 6671495 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 6671495 } ,
pre-text "(3)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5341 } ,
anchor "cd00267: ABC_ATPase; ABC (ATP-binding
cassette) transporter nucleotide-binding domain" } } ,
comment {
{
type other ,
text "Location: 931 - 1144 Blast Score: 454" ,
version 0 } ,
{
type other ,
text "Location: 1937 - 2152 Blast Score: 353" ,
version 0 } } } ,
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 13428 } ,
anchor "COG4152: COG4152; ABC-type uncharacterized
transport system, ATPase component [General function prediction only]" } } ,
comment {
{
type other ,
text "Location: 1937 - 2253 Blast Score: 387" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "AF000149" } ,
anchor "AF000149" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA" ,
accession "AF000149" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 3243083 } ,
anchor "AF000149" } } ,
seqs {
whole
gi 3243083 } ,
products {
{
type peptide ,
accession "AAC23916" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 2547314 } ,
anchor "AAC23916" } } ,
seqs {
whole
gi 2547314 } } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK053043" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 26095532 } ,
anchor "AK053043" } } ,
seqs {
whole
gi 26095532 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "AK084860" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 26102289 } ,
anchor "AK084860" } } ,
seqs {
whole
gi 26102289 } ,
products {
{
type peptide ,
text "None" ,
version 0 } } ,
comment {
{
type other ,
label "Strain" ,
text "C57BL/6J" ,
version 0 } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC043937" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 27882179 } ,
anchor "BC043937" } } ,
seqs {
whole
gi 27882179 } ,
products {
{
type peptide ,
accession "AAH43937" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 27882180 } ,
anchor "AAH43937" } } ,
seqs {
whole
gi 27882180 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "BC057853" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 34783941 } ,
anchor "BC057853" } } ,
seqs {
whole
gi 34783941 } ,
products {
{
type peptide ,
accession "AAH57853" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 34783942 } ,
anchor "AAH57853" } } ,
seqs {
whole
gi 34783942 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "11304" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
ig=NT_039240.3&gene=Abca4&lid=11304&from=8569037&to=8704334" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "11304" } ,
anchor "ModelMaker" ,
url "http://www.ncbi.nlm.nih.gov/mapview/modelmaker.cgi?taxid=10
090&contig=NT_039240.3&gene=Abca4&lid=11304" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Mm.3918" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Mm.3918" } ,
anchor "Mm.3918" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=39
18" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "11304" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
11304[loc]&TAXID=10090" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 109424 } ,
anchor "MGI" ,
url "http://www.informatics.jax.org/searches/accession_report.cg
i?id=MGI:109424" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Mus_musculus/contigview?geneid=BC057
853" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
BC057853" } } } ,
{
type comment ,
text "Human ABC-Transporter Proteins" ,
version 0 ,
source {
{
src {
db "Human ABC-Transporter Proteins" ,
tag
str "Human ABC-Transporter Proteins" } ,
anchor "Human ABC-Transporter Proteins" ,
url "http://nutrigene.4t.com/humanabc.htm" } } } } } ,
{
type comment ,
heading "Alleles" ,
version 0 ,
comment {
{
type comment ,
text "The following allele types are documented at Mouse Genome
Informatics" ,
version 0 ,
source {
{
anchor "(MGI)" ,
url "http://www.informatics.jax.org/searches/allele_report.cgi?m
arkerID=MGI:109424" } } } ,
{
type comment ,
heading "Targeted (knock-out) (1)" ,
version 0 ,
refs {
pmid 10412977 } } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11304 } ,
{
db "MGI" ,
tag
id 109424 } } ,
xtra-index-terms {
"LOC11304" } }
Entrezgene ::= {
track-info {
geneid 11305 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 2 ,
day 17 ,
hour 12 ,
minute 54 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } ,
subtype {
{
subtype chromosome ,
name "2" } } } ,
gene {
locus "Abca2" ,
desc "ATP-binding cassette, sub-family A (ABC1), member 2" ,
maploc "2 12.6 cM" ,
syn {
"Abc2" ,
"mKIAA1062" ,
"D2H0S1474E" } ,
locus-tag "MGI:99606" } ,
prot {
name {
"ATP-binding cassette, sub-family A (ABC1), member 2" ,
"ATP-binding cassette 2" } } ,
location {
{
display-str "2 A2-B" ,
method
map-type cyto } ,
{
display-str "2 12.6 cM" ,
method
map-type cM } } ,
gene-source {
src "LocusLink" ,
src-int 11305 ,
src-str2 "11305" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000068" ,
version 1 ,
seqs {
int {
from 25388791 ,
to 25408220 ,
strand plus ,
id
gi 51860766 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_007379" ,
version 1 ,
genomic-coords {
mix {
int {
from 25388791 ,
to 25388856 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25392017 ,
to 25392110 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25393119 ,
to 25393230 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25393315 ,
to 25393478 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25393703 ,
to 25393830 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25393985 ,
to 25394095 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25394330 ,
to 25394548 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25394911 ,
to 25395278 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25395520 ,
to 25395679 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25396389 ,
to 25396517 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25396610 ,
to 25396774 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25396851 ,
to 25396947 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25397266 ,
to 25397439 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25397509 ,
to 25397611 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25397686 ,
to 25397800 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25397914 ,
to 25398104 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25398252 ,
to 25398402 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25398479 ,
to 25398683 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25398822 ,
to 25398986 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25399088 ,
to 25399268 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25399348 ,
to 25399560 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25400546 ,
to 25400742 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25400831 ,
to 25401013 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25401209 ,
to 25401393 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25401500 ,
to 25401620 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25401896 ,
to 25402132 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25402212 ,
to 25402418 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25402671 ,
to 25402773 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25402856 ,
to 25403175 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25403250 ,
to 25403463 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25403550 ,
to 25403655 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25403747 ,
to 25403858 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25403948 ,
to 25404008 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25404091 ,
to 25404265 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25404346 ,
to 25404461 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25404543 ,
to 25404690 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25404835 ,
to 25404958 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25405093 ,
to 25405225 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25405329 ,
to 25405446 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25405571 ,
to 25405749 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25405991 ,
to 25406132 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25406232 ,
to 25406366 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25406459 ,
to 25406562 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25406636 ,
to 25406728 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25406812 ,
to 25406914 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25406999 ,
to 25407136 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25407221 ,
to 25407421 ,
strand plus ,
id
gi 51860766 } ,
int {
from 25407862 ,
to 25408220 ,
strand plus ,
id
gi 51860766 } } } ,
seqs {
whole
gi 11993938 } ,
products {
{
type peptide ,
heading "Reference" ,
accession "NP_031405" ,
version 1 ,
genomic-coords {
packed-int {
{
from 25388791 ,
to 25388856 ,
strand plus ,
id
gi 51860766 } ,
{
from 25392017 ,
to 25392110 ,
strand plus ,
id
gi 51860766 } ,
{
from 25393119 ,
to 25393230 ,
strand plus ,
id
gi 51860766 } ,
{
from 25393315 ,
to 25393478 ,
strand plus ,
id
gi 51860766 } ,
{
from 25393703 ,
to 25393830 ,
strand plus ,
id
gi 51860766 } ,
{
from 25393985 ,
to 25394095 ,
strand plus ,
id
gi 51860766 } ,
{
from 25394330 ,
to 25394548 ,
strand plus ,
id
gi 51860766 } ,
{
from 25394911 ,
to 25395278 ,
strand plus ,
id
gi 51860766 } ,
{
from 25395520 ,
to 25395679 ,
strand plus ,
id
gi 51860766 } ,
{
from 25396389 ,
to 25396517 ,
strand plus ,
id
gi 51860766 } ,
{
from 25396610 ,
to 25396774 ,
strand plus ,
id
gi 51860766 } ,
{
from 25396851 ,
to 25396947 ,
strand plus ,
id
gi 51860766 } ,
{
from 25397266 ,
to 25397439 ,
strand plus ,
id
gi 51860766 } ,
{
from 25397509 ,
to 25397611 ,
strand plus ,
id
gi 51860766 } ,
{
from 25397686 ,
to 25397800 ,
strand plus ,
id
gi 51860766 } ,
{
from 25397914 ,
to 25398104 ,
strand plus ,
id
gi 51860766 } ,
{
from 25398252 ,
to 25398402 ,
strand plus ,
id
gi 51860766 } ,
{
from 25398479 ,
to 25398683 ,
strand plus ,
id
gi 51860766 } ,
{
from 25398822 ,
to 25398986 ,
strand plus ,
id
gi 51860766 } ,
{
from 25399088 ,
to 25399268 ,
strand plus ,
id
gi 51860766 } ,
{
from 25399348 ,
to 25399560 ,
strand plus ,
id
gi 51860766 } ,
{
from 25400546 ,
to 25400742 ,
strand plus ,
id
gi 51860766 } ,
{
from 25400831 ,
to 25401013 ,
strand plus ,
id
gi 51860766 } ,
{
from 25401209 ,
to 25401393 ,
strand plus ,
id
gi 51860766 } ,
{
from 25401500 ,
to 25401620 ,
strand plus ,
id
gi 51860766 } ,
{
from 25401896 ,
to 25402132 ,
strand plus ,
id
gi 51860766 } ,
{
from 25402212 ,
to 25402418 ,
strand plus ,
id
gi 51860766 } ,
{
from 25402671 ,
to 25402773 ,
strand plus ,
id
gi 51860766 } ,
{
from 25402856 ,
to 25403175 ,
strand plus ,
id
gi 51860766 } ,
{
from 25403250 ,
to 25403463 ,
strand plus ,
id
gi 51860766 } ,
{
from 25403550 ,
to 25403655 ,
strand plus ,
id
gi 51860766 } ,
{
from 25403747 ,
to 25403858 ,
strand plus ,
id
gi 51860766 } ,
{
from 25403948 ,
to 25404008 ,
strand plus ,
id
gi 51860766 } ,
{
from 25404091 ,
to 25404265 ,
strand plus ,
id
gi 51860766 } ,
{
from 25404346 ,
to 25404461 ,
strand plus ,
id
gi 51860766 } ,
{
from 25404543 ,
to 25404690 ,
strand plus ,
id
gi 51860766 } ,
{
from 25404835 ,
to 25404958 ,
strand plus ,
id
gi 51860766 } ,
{
from 25405093 ,
to 25405225 ,
strand plus ,
id
gi 51860766 } ,
{
from 25405329 ,
to 25405446 ,
strand plus ,
id
gi 51860766 } ,
{
from 25405571 ,
to 25405749 ,
strand plus ,
id
gi 51860766 } ,
{
from 25405991 ,
to 25406132 ,
strand plus ,
id
gi 51860766 } ,
{
from 25406232 ,
to 25406366 ,
strand plus ,
id
gi 51860766 } ,
{
from 25406459 ,
to 25406562 ,
strand plus ,
id
gi 51860766 } ,
{
from 25406636 ,
to 25406728 ,
strand plus ,
id
gi 51860766 } ,
{
from 25406812 ,
to 25406914 ,
strand plus ,
id
gi 51860766 } ,
{
from 25406999 ,
to 25407136 ,
strand plus ,
id
gi 51860766 } ,
{
from 25407221 ,
to 25407421 ,
strand plus ,
id
gi 51860766 } ,
{
from 25407862 ,
to 25407897 ,
strand plus ,
id
gi 51860766 } } } ,
seqs {
whole
gi 11993939 } } } } } } ,
{
type genomic ,
heading "Reference" ,
accession "NT_039206" ,
version 3 ,
seqs {
int {
from 2857415 ,
to 2876844 ,
strand plus ,
id
gi 51706164 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "NM_007379" ,
version 1 ,
genomic-coords {
mix {
int {
from 2857415 ,
to 2857480 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2860641 ,
to 2860734 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2861743 ,
to 2861854 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2861939 ,
to 2862102 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2862327 ,
to 2862454 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2862609 ,
to 2862719 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2862954 ,
to 2863172 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2863535 ,
to 2863902 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2864144 ,
to 2864303 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2865013 ,
to 2865141 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2865234 ,
to 2865398 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2865475 ,
to 2865571 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2865890 ,
to 2866063 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2866133 ,
to 2866235 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2866310 ,
to 2866424 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2866538 ,
to 2866728 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2866876 ,
to 2867026 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2867103 ,
to 2867307 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2867446 ,
to 2867610 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2867712 ,
to 2867892 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2867972 ,
to 2868184 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2869170 ,
to 2869366 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2869455 ,
to 2869637 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2869833 ,
to 2870017 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2870124 ,
to 2870244 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2870520 ,
to 2870756 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2870836 ,
to 2871042 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2871295 ,
to 2871397 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2871480 ,
to 2871799 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2871874 ,
to 2872087 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2872174 ,
to 2872279 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2872371 ,
to 2872482 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2872572 ,
to 2872632 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2872715 ,
to 2872889 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2872970 ,
to 2873085 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2873167 ,
to 2873314 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2873459 ,
to 2873582 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2873717 ,
to 2873849 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2873953 ,
to 2874070 ,
strand plus ,
id
gi 51706164 } ,
int {
from 2874195 ,
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strand plus ,
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gi 51706164 } ,
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gi 51706164 } ,
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strand plus ,
id
gi 51706164 } ,
int {
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strand plus ,
id
gi 51706164 } } } ,
seqs {
whole
gi 11993938 } ,
products {
{
type peptide ,
heading "Reference" ,
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genomic-coords {
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gi 51706164 } ,
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gi 51706164 } ,
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id
gi 51706164 } ,
{
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strand plus ,
id
gi 51706164 } ,
{
from 2876486 ,
to 2876521 ,
strand plus ,
id
gi 51706164 } } } ,
seqs {
whole
gi 11993939 } } } } } } } ,
properties {
{
type comment ,
label "Nomenclature" ,
version 0 ,
source {
{
anchor "Mouse Genome Informatics" } } ,
properties {
{
type property ,
label "Official Symbol" ,
text "Abca2" ,
version 0 } ,
{
type property ,
label "Official Full Name" ,
text "ATP-binding cassette, sub-family A (ABC1), member 2" ,
version 0 } } } ,
{
type comment ,
heading "GeneOntology" ,
version 0 ,
source {
{
pre-text "Provided by" ,
anchor "MGI" ,
url "http://www.informatics.jax.org/" } } ,
comment {
{
type comment ,
label "Function" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 5524 } ,
anchor "ATP binding" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 16887 } ,
anchor "ATPase activity" ,
post-text "evidence: IEA" } } } ,
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 5215 } ,
anchor "transporter activity" ,
post-text "evidence: ISS" } } } } } ,
{
type comment ,
label "Process" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 8203 } ,
anchor "cholesterol metabolism" ,
post-text "evidence: ISS" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 6810 } ,
anchor "transport" ,
post-text "evidence: IEA" } } } } } ,
{
type comment ,
label "Component" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
refs {
pmid 12466851 } ,
source {
{
src {
db "GO" ,
tag
id 16021 } ,
anchor "integral to membrane" ,
post-text "evidence: TAS" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "GO" ,
tag
id 5765 } ,
anchor "lysosomal membrane" ,
post-text "evidence: ISS" } } } } } } } } ,
homology {
{
type comment ,
heading "Human, Rat" ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
id 55590 } ,
anchor "Map Viewer" ,
url "http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=10090&chr=2&
MAPS=genes-r-org/human-chr/mouse%3A2,genes-r-org/rat-chr/mouse%3A2,genes-r-org
/mouse-chr2&query=e%3A11305[id]+AND+gene[obj_type]&QSTR=abca2&cmd=focus&fill=1
0" } } } } ,
comments {
{
type comment ,
heading "LocusTagLink" ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 99606 } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "PROVISIONAL" ,
version 0 } ,
{
type comment ,
version 0 ,
refs {
pmid 14621295 ,
pmid 12466851 ,
pmid 8088782 } } ,
{
type comment ,
heading "Markers (Sequence Tagged Sites/STS)" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "UniSTS" ,
tag
id 158928 } ,
anchor "AI413825" ,
post-text "(e-PCR)" } } ,
comment {
{
type other ,
label "Alternate name" ,
text "421529" ,
version 0 } } } } } ,
{
type comment ,
heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_007379" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 11993938 } ,
anchor "NM_007379" } } ,
seqs {
whole
gi 11993938 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_031405" ,
version 1 ,
source {
{
src {
db "Protein" ,
tag
id 11993939 } ,
anchor "NP_031405" ,
post-text "ATP-binding cassette, sub-family A (ABC1), member
2" } } ,
seqs {
whole
gi 11993939 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 11993939 } ,
pre-text "(2)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5341 } ,
anchor "cd00267: ABC_ATPase; ABC (ATP-binding
cassette) transporter nucleotide-binding domain" } } ,
comment {
{
type other ,
text "Location: 1018 - 1205 Blast Score: 389" ,
version 0 } ,
{
type other ,
text "Location: 2051 - 2269 Blast Score: 372" ,
version 0 } } } } } } } } ,
comment {
{
type other ,
heading "Source Sequence" ,
version 0 ,
source {
{
src {
db "Nucleotide" ,
tag
str "X75927" } ,
anchor "X75927" } } ,
comment {
{
type other ,
version 0 } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA" ,
accession "AK129274" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 37360211 } ,
anchor "AK129274" } } ,
seqs {
whole
gi 37360211 } ,
products {
{
type peptide ,
accession "BAC98084" ,
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source {
{
src {
db "Protein" ,
tag
id 37360212 } ,
anchor "BAC98084" } } ,
seqs {
whole
gi 37360212 } } } } ,
{
type mRNA ,
heading "mRNA" ,
accession "X75927" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 11990230 } ,
anchor "X75927" } } ,
seqs {
whole
gi 11990230 } ,
products {
{
type peptide ,
accession "CAA53531" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 11990231 } ,
anchor "CAA53531" } } ,
seqs {
whole
gi 11990231 } } } ,
comment {
{
type other ,
label "Strain" ,
text "DBA/2" ,
version 0 } } } ,
{
type other ,
text "None" ,
version 0 ,
products {
{
type peptide ,
accession "P41234" ,
version 0 ,
source {
{
src {
db "Protein" ,
tag
id 14916951 } ,
anchor "P41234" } } ,
seqs {
whole
gi 14916951 } } } } } } ,
{
type comment ,
heading "Additional Links" ,
version 0 ,
comment {
{
type comment ,
version 0 ,
source {
{
src {
db "Evidence Viewer" ,
tag
str "11305" } ,
anchor "Evidence Viewer" ,
url "http://www.ncbi.nlm.nih.gov/sutils/evv.cgi?taxid=10090&cont
ig=NT_039206.3&gene=Abca2&lid=11305&from=2857416&to=2876845" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "ModelMaker" ,
tag
str "11305" } ,
anchor "ModelMaker" ,
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090&contig=NT_039206.3&gene=Abca2&lid=11305" } } } ,
{
type comment ,
text "UniGene" ,
version 0 ,
xtra-properties {
{
tag "UNIGENE" ,
value "Mm.2210" } } ,
source {
{
src {
db "UniGene" ,
tag
str "Mm.2210" } ,
anchor "Mm.2210" ,
url "http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=22
10" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "HomoloGene" ,
tag
str "11305" } ,
anchor "HomoloGene" ,
url "http://www.ncbi.nlm.nih.gov/HomoloGene/homolquery.cgi?TEXT=
11305[loc]&TAXID=10090" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "MGI" ,
tag
id 99606 } ,
anchor "MGI" ,
url "http://www.informatics.jax.org/searches/accession_report.cg
i?id=MGI:99606" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "Ensembl" ,
tag
str "" } ,
url "http://www.ensembl.org/Mus_musculus/contigview?geneid=X7592
7" } } } ,
{
type comment ,
version 0 ,
source {
{
src {
db "UCSC" ,
tag
str "" } ,
url "http://genome.ucsc.edu/cgi-bin/hgTracks?org=mouse&position=
X75927" } } } ,
{
type comment ,
text "Human ABC-Transporter Proteins" ,
version 0 ,
source {
{
src {
db "Human ABC-Transporter Proteins" ,
tag
str "Human ABC-Transporter Proteins" } ,
anchor "Human ABC-Transporter Proteins" ,
url "http://nutrigene.4t.com/humanabc.htm" } } } } } } ,
unique-keys {
{
db "LocusID" ,
tag
id 11305 } ,
{
db "MGI" ,
tag
id 99606 } } ,
xtra-index-terms {
"LOC11305" } }
Entrezgene ::= {
track-info {
geneid 11306 ,
status live ,
create-date
std {
year 2003 ,
month 8 ,
day 28 ,
hour 21 ,
minute 39 ,
second 0 } ,
update-date
std {
year 2005 ,
month 4 ,
day 19 ,
hour 12 ,
minute 12 ,
second 0 } } ,
type protein-coding ,
source {
genome genomic ,
origin natural ,
org {
taxname "Mus musculus" ,
common "house mouse" ,
db {
{
db "taxon" ,
tag
id 10090 } } ,
syn {
"mouse" } ,
orgname {
name
binomial {
genus "Mus" ,
species "musculus" } ,
lineage "Eukaryota; Metazoa; Chordata; Craniata; Vertebrata;
Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muridae; Murinae; Mus" ,
gcode 1 ,
mgcode 2 ,
div "ROD" } } ,
subtype {
{
subtype chromosome ,
name "X" } } } ,
gene {
locus "Abcb7" ,
desc "ATP-binding cassette, sub-family B (MDR/TAP), member 7" ,
maploc "X 39.0 cM" ,
syn {
"Abc7" } ,
locus-tag "MGI:109533" } ,
prot {
name {
"ATP-binding cassette, sub-family B (MDR/TAP), member 7" ,
"ATP-binding cassette 7" } } ,
location {
{
display-str "X C-D" ,
method
map-type cyto } ,
{
display-str "X 39.0 cM" ,
method
map-type cM } } ,
gene-source {
src "LocusLink" ,
src-int 11306 ,
src-str2 "11306" ,
gene-display FALSE ,
locus-display FALSE ,
extra-terms FALSE } ,
locus {
{
type genomic ,
heading "Reference" ,
accession "NC_000086" ,
version 1 ,
seqs {
int {
from 95684235 ,
to 95817474 ,
strand minus ,
id
gi 51869957 } } ,
products {
{
type mRNA ,
heading "Reference" ,
accession "XM_356348" ,
version 2 ,
genomic-coords {
mix {
int {
from 95684235 ,
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gi 51869957 } ,
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seqs {
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gi 51772276 } ,
products {
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type peptide ,
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gi 51869957 } } } ,
seqs {
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gi 38086485 } } } } } } ,
{
type genomic ,
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accession "NT_039711" ,
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int {
from 9312469 ,
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gi 51772331 } } ,
products {
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gi 51772276 } ,
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{
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{
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{
type generif ,
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type comment ,
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heading "NCBI Reference Sequences (RefSeq)" ,
version 0 ,
products {
{
type mRNA ,
heading "mRNA Sequence" ,
accession "NM_058265" ,
version 2 ,
source {
{
src {
db "Nucleotide" ,
tag
id 25143330 } ,
anchor "NM_058265" } } ,
seqs {
whole
gi 25143330 } ,
products {
{
type peptide ,
heading "Product" ,
accession "NP_490666" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 25143331 } ,
anchor "NP_490666" } } ,
seqs {
whole
gi 25143331 } ,
comment {
{
type other ,
heading "Conserved Domains" ,
version 0 ,
source {
{
src {
db "PROT_CDD" ,
tag
id 25143331 } ,
pre-text "(1)" ,
anchor "summary" } } ,
comment {
{
type other ,
version 0 ,
source {
{
src {
db "CDD" ,
tag
id 5372 } ,
anchor "cd00138: PLDc; Phospholipase D" } } ,
comment {
{
type other ,
text "Location: 20 - 172 Blast Score: 135" ,
version 0 } } } } } } } } } } } ,
{
type comment ,
heading "Related Sequences" ,
version 0 ,
products {
{
type genomic ,
heading "Genomic" ,
accession "AC024796" ,
version 1 ,
source {
{
src {
db "Nucleotide" ,
tag
id 7140352 } ,
anchor "AC024796" } } ,
seqs {
whole
gi 7140352 } ,
products {
{
type peptide ,
accession "AAK29892" ,
version 2 ,
source {
{
src {
db "Protein" ,
tag
id 16950493 } ,
anchor "AAK29892" } } ,
seqs {
whole
gi 16950493 } } } } } } ,
{
type comment ,
heading "RefSeq Status" ,
label "Reviewed" ,
version 0 } } ,
unique-keys {
{
db "LocusID" ,
tag
id 171594 } } ,
xtra-iq {
{
tag "NUCLEOTIDE" ,
value "7140352" } ,
{
tag "PROTEIN" ,
value "16950493" } } ,
non-unique-keys {
{
db "ID" ,
tag
id 25167480 } } }