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<entry>
<source releaseDate="2007-01-12">
<names>
<shortLabel>European Bioinformatics Institute</shortLabel>
</names>
<bibref>
<xref>
<primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</bibref>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
<attributeList>
<attribute name="postalAddress">Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom</attribute>
<attribute name="url">http://www.ebi.ac.uk</attribute>
</attributeList>
</source>
<experimentList>
<experimentDescription id="2">
<names>
<shortLabel>knochel-1999-1</shortLabel>
<fullName>The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications.</fullName>
</names>
<bibref>
<xref>
<primaryRef db="pubmed" dbAc="MI:0446" id="10449718" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</bibref>
<xref>
<primaryRef db="intact" dbAc="MI:0469" id="EBI-1028078" secondary="knochel-1999-1"/>
<secondaryRef db="newt" dbAc="MI:0247" id="2287" refType="target-species" secondary="sulso"/>
</xref>
<hostOrganismList>
<hostOrganism ncbiTaxId="-1">
<names>
<shortLabel>in vitro</shortLabel>
</names>
</hostOrganism>
</hostOrganismList>
<interactionDetectionMethod>
<names>
<shortLabel>x-ray</shortLabel>
<fullName>x-ray crystallography</fullName>
<alias>X-ray</alias>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</interactionDetectionMethod>
<participantIdentificationMethod>
<names>
<shortLabel>predetermined</shortLabel>
<fullName>predetermined participant</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="7940758" refType="go-definition-ref" refTypeAc="MI:0242"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</participantIdentificationMethod>
<attributeList>
<attribute name="author-list">Knochel T., Ivens A., Hester G., Gonzalez A., Bauerle R., Wilmanns M., Kirschner K., Jansonius JN.</attribute>
<attribute name="journal">Proc. Natl. Acad. Sci. U.S.A. (0027-8424)</attribute>
<attribute name="publication-year">1999</attribute>
<attribute name="dataset">MSD - Data obtained from The Macromolecular Structure Database</attribute>
</attributeList>
</experimentDescription>
</experimentList>
<interactorList>
<interactor id="4">
<names>
<shortLabel>trpe_sulso</shortLabel>
<fullName>Anthranilate synthase component 1</fullName>
<alias type="gene name" typeAc="MI:0301">trpE</alias>
<alias type="locus name" typeAc="MI:0305">SSO0893</alias>
</names>
<xref>
<primaryRef db="uniprotkb" dbAc="MI:0486" id="Q06128" refType="identity" refTypeAc="MI:0356" secondary="trpe_sulso" version="SP_56"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR006805" secondary="Anth_synth_I_N"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR005801" secondary="TRPE_1_chor_bd"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR010116" secondary="TrpE_arc_synth"/>
<secondaryRef db="intact" dbAc="MI:0469" id="EBI-1028059" secondary="trpe_sulso"/>
</xref>
<interactorType>
<names>
<shortLabel>protein</shortLabel>
<fullName>protein</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
<secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="identity" refTypeAc="MI:0356"/>
</xref>
</interactorType>
<organism ncbiTaxId="2287">
<names>
<shortLabel>sulso</shortLabel>
<fullName>Sulfolobus solfataricus</fullName>
</names>
</organism>
<sequence>MEVHPISEFASPFEVFKCIERDFKVAGLLESIGGPQYKARYSVIAWSTNGYLKIHDDPVNILNGYLKDLKLADIPGLFKGGMIGYISYDAVRFWEKIRDLKPAAEDWPYAEFFTPDNIIIYDHNEGKVYVNADLSSVGGCGDIGEFKVSFYDESLNKNSYERIVSESLEYIRSGYIFQVVLSRFYRYIFSGDPLRIYYNLRRINPSPYMFYLKFDEKYLIGSSPELLFRVQDNIVETYPIAGTRPRGADQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVKVPELMYVEKYSHVQHIVSKVIGTLKKKYNALNVLSATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKELLRIHAGAGIVYDSNPESEYFETEHKLKALKTAIGVR</sequence>
</interactor>
<interactor id="7">
<names>
<shortLabel>trpg_sulso</shortLabel>
<fullName>Anthranilate synthase component II</fullName>
<alias type="gene name" typeAc="MI:0301">trpG</alias>
<alias type="locus name" typeAc="MI:0305">SSO0894</alias>
</names>
<xref>
<primaryRef db="uniprotkb" dbAc="MI:0486" id="Q06129" refType="identity" refTypeAc="MI:0356" secondary="trpg_sulso" version="SP_52"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR006220" secondary="Anth_synthII"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR001317" secondary="CP_synthGATase"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR011702" secondary="GATASE"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR000991" secondary="GATase_1"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR012998" secondary="GATase_1_AS"/>
<secondaryRef db="interpro" dbAc="MI:0449" id="IPR006221" secondary="TrpG_papA"/>
<secondaryRef db="intact" dbAc="MI:0469" id="EBI-1028067" secondary="trpg_sulso"/>
</xref>
<interactorType>
<names>
<shortLabel>protein</shortLabel>
<fullName>protein</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
<secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="identity" refTypeAc="MI:0356"/>
</xref>
</interactorType>
<organism ncbiTaxId="2287">
<names>
<shortLabel>sulso</shortLabel>
<fullName>Sulfolobus solfataricus</fullName>
</names>
</organism>
<sequence>MDLTLIIDNYDSFVYNIAQIVGELGSYPIVIRNDEISIKGIERIDPDRIIISPGPGTPEKREDIGVSLDVIKYLGKRTPILGVCLGHQAIGYAFGAKIRRARKVFHGKISNIILVNNSPLSLYYGIAKEFKATRYHSLVVDEVHRPLIVDAISAEDNEIMAIHHEEYPIYGVQFHPESVGTSLGYKILYNFLNRV</sequence>
</interactor>
</interactorList>
<interactionList>
<interaction id="1">
<names>
<shortLabel>trpe-trpg-1</shortLabel>
<fullName>The crystal structure of anthranilate synthase from
sulfolobus solfataricus</fullName>
</names>
<xref>
<primaryRef db="intact" dbAc="MI:0469" id="EBI-1028084" secondary="trpe-trpg-1"/>
<secondaryRef db="pdb" dbAc="MI:0460" id="1QDL" refType="identity" refTypeAc="MI:0356"/>
</xref>
<experimentList>
<experimentRef>2</experimentRef>
</experimentList>
<participantList>
<participant id="3">
<interactorRef>4</interactorRef>
<biologicalRole>
<names>
<shortLabel>unspecified role</shortLabel>
<fullName>unspecified role</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</biologicalRole>
<experimentalRoleList>
<experimentalRole>
<names>
<shortLabel>neutral component</shortLabel>
<fullName>neutral component</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</experimentalRole>
</experimentalRoleList>
<featureList>
<feature id="5">
<names>
<shortLabel>region</shortLabel>
</names>
<featureType>
<names>
<shortLabel>sufficient to bind</shortLabel>
<fullName>sufficient binding site</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</featureType>
<featureRangeList>
<featureRange>
<startStatus>
<names>
<shortLabel>certain</shortLabel>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
</xref>
</startStatus>
<begin position="1"/>
<endStatus>
<names>
<shortLabel>certain</shortLabel>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
</xref>
</endStatus>
<end position="421"/>
</featureRange>
</featureRangeList>
</feature>
</featureList>
<hostOrganismList>
<hostOrganism ncbiTaxId="2287">
<names>
<shortLabel>sulso</shortLabel>
<fullName>Sulfolobus solfataricus</fullName>
</names>
</hostOrganism>
</hostOrganismList>
</participant>
<participant id="6">
<interactorRef>7</interactorRef>
<biologicalRole>
<names>
<shortLabel>unspecified role</shortLabel>
<fullName>unspecified role</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</biologicalRole>
<experimentalRoleList>
<experimentalRole>
<names>
<shortLabel>neutral component</shortLabel>
<fullName>neutral component</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
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</xref>
</experimentalRole>
</experimentalRoleList>
<featureList>
<feature id="8">
<names>
<shortLabel>region</shortLabel>
</names>
<featureType>
<names>
<shortLabel>sufficient to bind</shortLabel>
<fullName>sufficient binding site</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</featureType>
<featureRangeList>
<featureRange>
<startStatus>
<names>
<shortLabel>certain</shortLabel>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
</xref>
</startStatus>
<begin position="1"/>
<endStatus>
<names>
<shortLabel>certain</shortLabel>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
</xref>
</endStatus>
<end position="195"/>
</featureRange>
</featureRangeList>
</feature>
</featureList>
<hostOrganismList>
<hostOrganism ncbiTaxId="2287">
<names>
<shortLabel>sulso</shortLabel>
<fullName>Sulfolobus solfataricus</fullName>
</names>
</hostOrganism>
</hostOrganismList>
</participant>
</participantList>
<interactionType>
<names>
<shortLabel>direct interaction</shortLabel>
<fullName>direct interaction</fullName>
</names>
<xref>
<primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
<secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
</xref>
</interactionType>
<attributeList>
<attribute name="assembly">tetrameric, multimeric</attribute>
<attribute name="3d-r-factors">working 77.400%, free 74.600%</attribute>
<attribute name="3d-resolution">2.5A</attribute>
</attributeList>
</interaction>
</interactionList>
</entry>
</entrySet>